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9 Cards in this Set
- Front
- Back
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Cyclosporine
- Mechanism? - Clinical Use? - Toxicity? |
M: binds to cyclophilins
U: suppresses organ rejection after transplant, used for selected autoimmune disorders T: increased viral infections & lymphoma, nephrotoxic (prevent with mannitol) |
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Tacrolimus
- Mechanism? - Clinical Use? - Toxicity? |
M: binds to FK-binding protein, inhibits secretion of IL-2 & other cytokines
U: potent immunosuppressive used in organ transplant recipients T: significant nephrotoxicity, neuropathy, HTN, pleural effusion, hyperglycemia |
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Azathioprine
- Mechanism? - Clinical Use? - Toxicity? - Increased Toxicity with What? |
M: antimetabolite precursor of 6-mercaptopurine that interfaces with the metabolism & synthesis of nucleic acids
U: kidney transplant, autoimmune diseases (glomerulonephritis, hemolytic anemia) T: bone marrow suppresion M: increased toxicity with allopurinol (since active metabolite mercaptopurine is metabolized to xanthine oxidase) |
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Muromonab-CD3
- Mechanism? - Clinical Use? - Toxicity? |
M: monoclonal Ab that binds CD3 on surface of t-cells, blocks cellular interaction with CD3 protein responsible for tcell signal transduction
U: immunosuppression for kidney transplant T: cytokine-release syndrome, hypersensitivity rxn |
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Sirolimus
- Mechanism? - Clinical Use? With What? - Toxicity? |
M: binds to mTOR, inhibits tcell proliferation to IL-2
U: immunosuppression after kidney transplant (use with corticosteriods & cyclosporine) T: hyperlipidemia, thrombocytopenia, leukopenia |
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Mycophenolate mofetil
- Mechanism? |
M: inhibits denovo synthesis and blocks lymphocyte proliferation
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Daclizumab
- Mechanism? |
M: monoclonal Ab with high affinity for IL-2 receptor on activated tcells
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Aldesleukin?
Erythropoieten? Filgastrin? Clinical Use of Each? |
A - (IL-2) Renal Cell Carcinoma, Metastatic Melanoma
E - (Epoetin) Anemia (esp in Renal Failure) F - (GCS-F) Recovery of Bone Marrow |
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Sangramostim?
Alpha-IFN? Beta-IFN? Gamma-IFN? Oprelvekin? Thrombopoeiten? |
S - (GMC-SF) Recovery of Bone Marrow
A - HBV, HCV, Kaposi's Sarcome, Leukemia, Malignant Melanoma B - Multiple Sclerosis G - Chronic Granulomatous Disease O - (IL-11) Thrombocytopenia T - Thrombocytopenia |
