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21 Cards in this Set
- Front
- Back
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APC's are... (new definition)
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Cells expressing Class II MHC
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Cells expressing MHC Class I are called ____
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Target cells.
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APC's come in 2 categories. These are...
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Professional APC and Nonprofessional APC's
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Professional APC's (components)
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Express class II MHC and can deliver a 2 signal to the T-cells
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Professional APC's include (3)
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Dendritic cells, Macrophages, B-cells
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Nonprofessional APC's (when used)
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Induced to express Class II MHC for a SHORT TIME during a sustained INFLAMMATORY RESPONSE.
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Nonprofessional APC's are found in ______ _____ cells
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Vascular Epithelial Cells
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allograft
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A transplant organ or bone marrow transplant
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Two major types of Ag's are...
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Endogenous and exogenous
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Endogenous Ag's
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Processed in the cytosolic pathway and presented on Class I MHC
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Exogenous Ag's
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Extracellular Ag. Must be taken up by the APC and presented on Class II MHC. Processed through endocytic pathway.
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Cytosolic Processing Pathway (how it works)
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Proteins are ubiquinated by a protein called ubiquitin. This protein guides it into a proteasome where it is degraded.
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Ubiquitin
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Protein that assists MHC Class I cytosolic pathway by escorting Ag to site of death
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Proteasome
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Where Ag is degraded after ubiquitin transports it there
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TAP Proteins (what it stands for and what it does)
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Transporter of Antigenic Peptides. There are two: TAP-A and TAP-B. Peptide must be able to bind TAP to be presented. Increases level of diversity
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True/False: Binding of peptides stabilizes MHC Class I and II
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True
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Endocytic Processing Pathway
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MHC Class II. Works through phagocytosis and endocytosis which can be receptor mediated or pinocytosis
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Receptor mediated endocytosis
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Ag binding to Ab on the surface of a B-cell and being internalized
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Pinocytosis
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Done by dendritic cells. Thought as micro-phagocytosis
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How long does the endocytic pathway take and how does it progress?
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It takes about 1-3 hours. It involves three increasingly acidic compartments. Early endosome, late endosome, lysosome.
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Invariant Chain
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Interacts with peptide binding cleft and prevents any other proteins from binding to it.
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