Immunology Chap 10

Front 1

self =

Back 1

histocompatible

Front 2

nonself =

Back 2

histoincompatible

Front 3

MHC first descrived by _____ and _____

Back 3

Gorer and Schnell

Front 4

MHC is RNA or DNA?

Back 4

DNA

Front 5

There are three regions of genes that code for three diferent classes. These are...

Back 5

Class I Class II and Class III

Front 6

Class I MHC

Back 6

On surface of nearly all nucleated cells
Present peptide Ags for recognition by T-cells

Front 7

Class II MHC

Back 7

present cells to macrophages, dendritic cells, and B-cells. Present Ag to Th cells

Front 8

Class III

Back 8

Soluble serum proteins including some complement proteins and Tumer necrosis factors

Front 9

Class I has how many proteins?

Back 9

3

Front 10

Class II has how many proteins?

Back 10

6

Front 11

True/Flase: MHC genes are highly polymorphic

Back 11

True

Front 12

Polymorphic

Back 12

Many alternate forms of the same gene exist for different locus

Front 13

Explain MHC inheritance

Back 13

You inherit a haplotype from each parent. Both sets are expressed on every cell.

Front 14

What dont you have with MHC that you get with Ig and how is MHC expressed

Back 14

You do not get allelic exclusion with MHC and it is co-dominantly expressed

Front 15

Chances of a sibling having the same MHC as you

Back 15

1 in 4

Front 16

Class I MHC components

Back 16

Has a large alpha chain and a smaller Beta chain

Front 17

Class I MHC =

Back 17

CD8

Front 18

Class II MHC =

Back 18

CD4

Front 19

Class I MHC has 2 pairs of domains. These are...

Back 19

Membrane distal: alpha 1 + alpha 2
Membrane Proximal: alpha 3 + Beta 2 microglobulin

Front 20

alpha 1 and alpha 2 subunits interact to form...

Back 20

a platform of 8 antiparallel beta strands spanned by 2 long alpha helical regions. This makes a cleft with beta regions as the floor

Front 21

Class I MHC cleft holds how many AA's

Back 21

8-10

Front 22

Class I MHC processes _____ proteins that have been synthesized in the cell and degraded in cytoplasm

Back 22

endogenous

Front 23

Importance of Beta 2 in MHC Class I

Back 23

it is a structural helper and Class 1 does not go to the surface without it

Front 24

MHC Class I binding is _____

Back 24

Promiscuous

Front 25

_____ number of AA's bind best to cleft on MHC I. Explain binding details.

Back 25

9 AA's. Peptides bind through AA 1 and 2 and 8 and 9. AA 3-7 protrude outward for presentation to T-cells

Front 26

Class II MHC is found on _____

Back 26

APC's

Front 27

MHC Class II has 3 subregions. These are...

Back 27

DP, DQ, DR. Each has an alpha and a Beta sub-unit

Front 28

MHC Class II also have 2 different domains similar to MHC Class I. These are...

Back 28

Proximal and Distal

Front 29

Proximal Domain of MHC Class II

Back 29

Alpha 2 and Beta 2 have Ig domains

Front 30

Distal domain of MHC Class II

Back 30

Alpha 1 and Beta 1 and form a binding cleft that can bind longer AA sequences

Front 31

MHC Class II can bind how many AA's in its cleft? explain.

Back 31

13-18 and it binds them in a hot-dog like pattern. Bound in the middle and the ends are allowed to move freely

Front 32

MHC II peptides are from ____ proteins that have been degraded in _____ pathways by the APCs

Back 32

exogenous , endocytic

Front 33

Class I MHC is ______ and degrdes products in the ______ pathway

Back 33

Endogenous , exocytic - samples things from inside the cell and tells whether they r foreign

Front 34

Class II MHC is ______ and degrades products in the _____ pathways

Back 34

Exogenous , endocytic - shows what kind of Ags are from the outside of the cell to signal if its foreign

Front 35

How many possibilites of Class I and II MHC are there?

Back 35

4 x 10^9

Front 36

Almost all cells have MHC I. Name one organ that has a low number and makes it good for transplants.

Back 36

The liver. Brain, sperm, and splacental cells also sometimes do not have MHC Class I at all

Front 37

Class II MHC is only expressed on ____

Back 37

APC's: macrophages, B-cells, D.C.'s, thymic epithelial and activated T-cells

Front 38

Class I uses ____ # of proteins to bind a peptide and Class II uses ____ #.

Back 38

1 , 2

Front 39

How many different expression of Class II can an individual have?

Back 39

12. There are 4 possibilites for each of the 3 DP, DQ, and DR.

Front 40

____ can decrease Class I MHC

Back 40

HIV

Front 41

_____ can increase MHC Class I

Back 41

Measles

Front 42

____ and _____ can increase MHC Class II

Back 42

HIV and Measles

Front 43

Determinant Selection

Back 43

Different MHC respond to different peptides. So, you must express an MHC that can react to that specific peptide before you can respond immunologically.

Front 44

Holes in the Repertoire

Back 44

If a T-cell Ag receptor recoginzes a self peptide MHC that T-cell is deleted. So, if there is a viral protein that is similar, you wont have an MHC to react

Front 45

Marek's disease Herpes Virus

Back 45

Disease in chickens. If they express B19 allele they are susceptible but if they express B21 they are not

Front 46

Jeffrey Amhurst

Back 46

Gave small-pox blankets to indians and caused 30% death. First germ warfare.