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18 Cards in this Set
- Front
- Back
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Subclasses of IgG
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IgG1
IgG2 IgG3 IgG4 |
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Subclasses of IgA
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IgA1
IgA2 |
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Antibody avidity
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Overall binding energy of all the binding sites with antigen
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Half life of IgA
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One week
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What is the major antibody of milk and colostrum?
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IgA
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Function of IgD
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Unknown
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What is 75% of total circulating immunoglobulin?
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IgG
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Half life of IgG
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3 weeks
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IgG facilitates the elimination of microbes by
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Opsonization
ADCC Component activation Neutralization of virus adn toxins |
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Opsonization
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Phagocytosis triggered following binding of the Fc region of antibodies, bound by the pathogen, to FcγR on phagocytes
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Neutralization
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IgG binds antigen to inhibit the antigen's ability to bind to a cell surface receptor
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Half life of IgG3
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One week
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What subtype of IgG is the most effective activator of complement?
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IgG3
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What antibody represents 15% of the total immunoglobulin?
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IgM
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Half life of IgM
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5 - 7 days
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Cross-linking
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One antigen is bound by two antibodies
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Cross-reactivity
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Antibodies that have been generated to one epitope on an antigen can bind (usually with lower affinity) an epitope that is very similar on a different antigen
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Limitations of monoclonal antibodies as therapeutic agents
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HAMA response
Antibodies against mouse variable region domains in humanized chimeric antibodies Size of antibody Formation of immunoconjugates requires stable linkage to prevent deposition of free drug or radioisotope into healthy tissues Treatment of cancers with immunoconjugates is limited by general lack of tissue specific antigens on most cancer cells |
