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5 Cards in this Set
- Front
- Back
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IgM
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- Pentamer
- Has a J Chain - 1st Ig class to be produced w/ initial exposure - very effective complement activator (b/c pentameric) -half life = 5-7 days - only Ig in immature B cells - expressed in naive B cells along with IgD - monomeric form on mature and immature naive B-cells - strong agglutination - has low affinity but high avidity (10 binding sites) -900 kD |
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IgA
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- In secretions (tears, mucous, saliva, breast milk)
- localized defense of mucous membranes Half life - 1 week - J chain - holds the 2 monomers together. - Secretory Component 320 kD |
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IgG
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- very abundant
- circulates between blood and interstitial fluid - only Ig that crosses placenta - promotes opsonization, neutralization, agglutination - IgG1 - highest conc - IgG3 - most effective IgG activator of complement - IgG4 - lowest conc. & does not activate complement - 150kD - intravascular and extravascular |
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IgD
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- in naive B cells (with IgM)
- antigen stimulated proliferation - Exists only as a membrane bound form - 180kD |
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IgE
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- bound to basophils and mast cells on FcεR
- trigger release of mast cells, basophils of histamine - Helminths - Allergic reactions (reaginic antibody) - half life - 2 days - 200 kD |
