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12 Cards in this Set
- Front
- Back
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Structure?
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Basic unit comprises two heavy chains and two light chains (k & lamda) joined by a disulphide bridge
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Structure of chains in antibodies?
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Each chain consists of several Ig repeats, variable and conserved regions, joining region and diversity regions (HC only)
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IgM (u) class?
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first to be produced, natural ab in peritoneum, complement activation
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IgD (delta)
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naive B cells ag receptors, trigger B cells
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IgA (alpha)
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epithelial/mucosal immunity, lungs, airbourne
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IgE (epsilom)
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helminthic parasite (tapeworm) and immediate hypersensitivity
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IgG (gamma)
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75% of ab are this class, secondary exposure, neonatal immunity, ab dependant cell mediate cytotoxicity, (oposination, complement activation)
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Structure IgM?
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pentamer, 10 bindig sites, high avidity
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Structure IgA?
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Dimer, 4 binding sites
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Structure IgE?
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monomer, 2 binding sites
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Structure IgG?
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monomer, 2 binding sites
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Draw structure of antibody?
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