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36 Cards in this Set
- Front
- Back
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IL-1
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Endogenous pyrogen
Stimulate T, B, M0, PMN Fibroblast and epithelial growth and differentiation By: Macrophages (Only IL with direct inhibitor = anakinra) |
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IL-2
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T cell growth
By: T cells |
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IL-3
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BM growth/differentiation
(like GM-CSF) By: T cells |
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IL-4
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Th2 differentiation
Growth of B cells Class switch to IgA Class switch to IgG By: Th2 |
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IL-5
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B differentiation
Class switch to IgA Activation of eosinophils By: Th2 |
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IL-6
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Stimulation of acute phase reactants and Ig
By: T cells and M0 |
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IL-8
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Neutrophil chemotaxis
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IL-10
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Th2 Differentiation
(Th1 Inhibition) |
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IL-12
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Activation of NK
Activation of Th1 By: B and M0 |
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IFN gamma
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M0 stimulation
By: Th1 |
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TNF Alpha
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Activation of T
Proliferation of B Neutrophil chemoattract DC migration to LN By: M0 |
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IFN alpha
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Inhibition of viral protein synthesis
Activation of NK |
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Antinuclear antibodies
(ANA) |
SLE
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Anti-dsDNA
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SLE
(specific) |
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Anti-Smith
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SLE
(Specific) |
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Anti-histone
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drug-induced SLE
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P-ANCA
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Polyarteritis Nodosum
Other vasculitis |
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C-ANCA
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Wegener's Granulomatosis
? Other vasculitis |
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Anti-centromere
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CREST
(Calcinosis, Raynaud, Esophageal dysmotility, Sclerodactyly, Telangiectasia) |
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Anti-Scl-70
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Diffuse scleroderma
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Anti-mitochondrial
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Primary biliary cirrhosis
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Anti-Gliadin
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Celiac Sprue
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Anti-basement membrane
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Goodpasture Syndrome
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Anti-desmosomes
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Pemphigus vulgaris
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Anti-hemidesmosomes
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Bullous pemphigoid
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Anti-microsomal
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Hashimoto's Thyroiditis
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Anti-Jo-1
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Polymyositis
Dermatomyositis |
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Anti-ssDNA
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Mixed connective tissue dz
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Anti-U1 RNP
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Mixed connective tissue dz
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HLA B27
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1. Ankylosing Spondylitis
2. Psoriatic Arthritis 3. Reiter's Syndnrome 4. UC 5. Crohn's |
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HLA B8
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Grave's Dz
Celiac Sprue |
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HLA DR2
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MS
"Hay fever" Goodpasture SLE |
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HLA DR3
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Type 1 DM
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HLA DR4
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Type 1 DM
RA |
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HLA DR7
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Nephrotic Syndrome (steroid-sensitive)
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HLA DR5
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Pernicious anemia
Hashimoto's Thyroiditis |
