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36 Cards in this Set

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  • Back
IL-1
Endogenous pyrogen
Stimulate T, B, M0, PMN
Fibroblast and epithelial growth and differentiation

By: Macrophages

(Only IL with direct inhibitor = anakinra)
IL-2
T cell growth

By: T cells
IL-3
BM growth/differentiation
(like GM-CSF)

By: T cells
IL-4
Th2 differentiation
Growth of B cells
Class switch to IgA
Class switch to IgG

By: Th2
IL-5
B differentiation
Class switch to IgA
Activation of eosinophils

By: Th2
IL-6
Stimulation of acute phase reactants and Ig

By: T cells and M0
IL-8
Neutrophil chemotaxis
IL-10
Th2 Differentiation
(Th1 Inhibition)
IL-12
Activation of NK
Activation of Th1

By: B and M0
IFN gamma
M0 stimulation

By: Th1
TNF Alpha
Activation of T
Proliferation of B
Neutrophil chemoattract
DC migration to LN

By: M0
IFN alpha
Inhibition of viral protein synthesis
Activation of NK
Antinuclear antibodies
(ANA)
SLE
Anti-dsDNA
SLE
(specific)
Anti-Smith
SLE
(Specific)
Anti-histone
drug-induced SLE
P-ANCA
Polyarteritis Nodosum
Other vasculitis
C-ANCA
Wegener's Granulomatosis
? Other vasculitis
Anti-centromere
CREST
(Calcinosis, Raynaud, Esophageal dysmotility, Sclerodactyly, Telangiectasia)
Anti-Scl-70
Diffuse scleroderma
Anti-mitochondrial
Primary biliary cirrhosis
Anti-Gliadin
Celiac Sprue
Anti-basement membrane
Goodpasture Syndrome
Anti-desmosomes
Pemphigus vulgaris
Anti-hemidesmosomes
Bullous pemphigoid
Anti-microsomal
Hashimoto's Thyroiditis
Anti-Jo-1
Polymyositis
Dermatomyositis
Anti-ssDNA
Mixed connective tissue dz
Anti-U1 RNP
Mixed connective tissue dz
HLA B27
1. Ankylosing Spondylitis
2. Psoriatic Arthritis
3. Reiter's Syndnrome
4. UC
5. Crohn's
HLA B8
Grave's Dz
Celiac Sprue
HLA DR2
MS
"Hay fever"
Goodpasture
SLE
HLA DR3
Type 1 DM
HLA DR4
Type 1 DM
RA
HLA DR7
Nephrotic Syndrome (steroid-sensitive)
HLA DR5
Pernicious anemia
Hashimoto's Thyroiditis