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7 Cards in this Set
- Front
- Back
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Burkitt's Lymphoma (FAB L3)
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Mistake in B-cell rearrangement. Immunoglobulin gene accidentally joined to gene involved in cellular growth. Results in B-cell tumors
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X Linked Agammaglobulemia
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sex linked. Bcell develpment stops at pre B cell stage. Recurrent EC infections:
Haemophilus influenzae Streptococcus pneumoniae Streptococcus pyogenes Staphylococcus aureus Patients must be treated with antibiotics and immunoglobulin from pooled blood |
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Mutiple Myeloma
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Malignancy of plasma cells at the end stage of Bcell development
Causes bone disease-tumors arise in bone marrow=erosion of bone Excess production of monoclonal antibody- IgG or IgA. Excess production of light chains that are excreted in urine. Bence Jones proteins occur upon heating the urine. Increase sedimentation occurs-Rouleaux formation |
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T cells recognize
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Processed proteins
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The co-stimulatory receptor on an epithelial cell is ______.
CD4 CD28 CD80/CD86 CD3 |
none of these. no antigen presenting cell because its an epithelial cell. it only presents to a T cell.
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Superantigens
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Superantigens (SAgs) are a distinct class of antigens that stimulate a primary T cell response after being presented as an intact protein molecule (unlike as a peptide: MHC complex) by MHC class II molecules
Bacterial superantigens: Staphylococcal enterotoxin (SE), Toxic shock syndrome toxin (TSST) Viral superantigen (yet to be established, antigen not characterized): Rabies viral antigen and Epstein Barr viral antigen Superantigen binds to the Vb region of TCR and to the outer surface of MHC class II molecule. SAg induces a polyclonal T cell response resulting in production of large amount of cytokines (IL-1, IL-2, TNF-a) responsible for inducing a systemic shock, hence Toxic shock syndrome. SAg also inhibits induction of specific adaptive response which favors the pathogenicity of the bacteria. Bacterial superantigens: Staphylococcal enterotoxin (SE), Toxic shock syndrome toxin (TSST) Viral superantigen (yet to be established, antigen not characterized): Rabies viral antigen and Epstein Barr viral antigen Superantigen binds to the Vb region of TCR and to the outer surface of MHC class II molecule. SAg induces a polyclonal T cell response resulting in production of large amount of cytokines (IL-1, IL-2, TNF-a) responsible for inducing a systemic shock, hence Toxic shock syndrome. SAg also inhibits induction of specific adaptive response which favors the pathogenicity of the bacteria. Bacterial superantigens: Staphylococcal enterotoxin (SE), Toxic shock syndrome toxin (TSST) Viral superantigen (yet to be established, antigen not characterized): Rabies viral antigen and Epstein Barr viral antigen Superantigen binds to the Vb region of TCR and to the outer surface of MHC class II molecule. SAg induces a polyclonal T cell response resulting in production of large amount of cytokines (IL-1, IL-2, TNF-a) responsible for inducing a systemic shock, hence Toxic shock syndrome. SAg also inhibits induction of specific adaptive response which favors the pathogenicity of the bacteria |
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bare lymphocyte syndrome
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Deficiency of TAP protein cause a rare disease called bare lymphocyte syndrome
• <1% MHC class I molecule expression • Poor CD8 response • Chronic viral respiratory infection |
