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30 Cards in this Set
- Front
- Back
- 3rd side (hint)
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B cell fxn
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makes Ab
IgG opsonize bacteria, virus IgE hypersens cytotoxic immune complex IgG hyperacute organ rejection |
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Th1 cell fxn
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activated by IL12
secretes IFN gamma --> mac secretes IL2 --> cytotoxic T inh by IL4 |
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Th2 cell fxn
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activated by IL4
secretes IL4, IL5 --> help B make Ab inh by IFN gamma delayed hypersensitivity |
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APCs
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macrophage --> Th1
dendritic cell --> Th2 B cell --> Th2 |
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humoral
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blood
B cells, PMN bacteria Th2 --> IL4,5,6,10; Ab |
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cell mediated
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tissue
T cells, macrophages everything else Th1 --> IL-2, IFN-gamma APC--mac |
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1st response to cell injury
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Na-K shuts down
- inc K, dec Na |
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pulmonary alveolus of lungs
connective tissue liver neural tissue granulomas bone spleen kidney |
Dust cells/Alveolar macrophages
Histiocytes Kupffer cells Microglia Epithelioid cells Osteoclasts Sinusoidal lining cells Mesangial cells |
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neutrophils 2 secretions
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myeloperoxidase --> G+
NADPH oxidase --> G+/- |
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defect in NADPH oxidase in PMN
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chronic granulomatous dz
NBT - |
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allergic rashes
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erythema multiform -- target
Steven's Johnson -- mucosal surface Toxic epidermal necrolysis -- skin sloughs off |
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Mast cell degran --- eosinophil
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histamine --- histaminase
SRSA --- arylsulfitase ECF-A --- heparin to dec clots due to bronchodilation |
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cat positive bacteria
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staph, pseudomonas, neisseria (all in throat)
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abscess duration
1-3 days 4-7 days 7+ |
staph
strep anaerobe |
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Eosinophilia
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NAACP
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neoplasm, asthma/addison's, allergies, collagen vesicle dz, parasites
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pulm infiltrate w/ eosinophilia
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aspergillosis
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prednisone actions
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kills T cells, eosinophils
inh macrophages stabilizes endothelium stabilizes mast cells inh phospholipase A |
KISSI
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throat germs
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strep pyogenes, s. pneumoniae, H. influenza, neisseria
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septic emboli
brain retina fingers toes nail bed |
mycotic aneurysm
roth spot osler's nodes january lesion splinter hemorrhage |
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8 live vaccines
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MMR (3) -- shed for 2 mo
oral polio -- shed for 6 wk BCG -- for TB varicella yellow fever rotavirus |
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cryoglobinemia
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influenza, adenovirus, mycoplasma,
IgM increases |
I AM HE
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IL-1
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pyrogen, acute inflammation, recruits leukocytes
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IL-2
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from Th1 to Tc; death message
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IL-3
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bone marrow stimulation
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IL-4
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B-cell growth
IL-5 -- B-cell differentiation |
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IL8
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stimulate PMN
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IL12
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stimulate Th1
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gamma-IFN
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stim mac
IFN interfere with viral protein synthesis |
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TNF-alpha
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from macrophages, recruits leukocytes, vascular leak, wt loss
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HLA B27
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psoriasis, ankylosing spondylitis, IBS, Reiter's
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PAIR
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