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110 Cards in this Set

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IL-1
Endogenous pyrogen
Stimulates T cells, B cells, neutrophils, fibroblasts & epithelial cells
IL-2
Stimulates T cells and enhances activity of NK cells
IL-3
Stimulates bone marrow stem cells
IL-4
Enhances class switching to IgE
Stimulates B cells and mast cells
IL-5
Enhances class switching to IgA
Stimulates eosinophils & enhances IL-2 receptor expresion
IL-6
Stimulates production of acute-phase reactants & Ig's
IL-7
Stimulates pre-B and pre-T cells
IL-8
Major chemotactic factor for neutrophils
IL-9
T-cell mitogen
IL-10
Stimulates Th2 while inhibiting Th1
IL-11
Stimulates hematopoeisis & enhances acute-phase protein synthesis
IL-12
Activates NK cells & Th1 cells
IL-13
Inhibits inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, MCP)
IL-15
T-cell mitogen & enhances growth of intestinal epithelium
IL-16
Increases class II MHC, chemotaxis & Th cell cytokines
IL-17
Increases the inflammatory response
IL-18
Increases IFN-gamma production & NK cell action
IFN-alpha
Inhibits viral replication
IFN-beta
Inhibits viral replication
IFN-gamma
Stimulates macrophages, Increases expression of MHC II's on APC's, antiviral properties, inhibits IL-4 activation of mast cells & IgE synthesis
TNF-alpha
Tumor necrosis factor-alpha
Attracts & activates neutrophils, Cytotoxic to tumors, stimulates dendritic cell migration to lymph nodes, increases IL-2 receptor synthesis in Th cells
TNF-beta
Tumor necrosis factor-alpha
cytotoxic for tumors
TGF-beta
Transforming growth factor-B
inhibits proliferation of B&T cells, reduces cytokine receptors, potent chemotactic agent for leukocytes, Mediates inflammation & tissue repair
CD2
Present on peripheral T cell
Ligand is (LFA-3/CD58)
CD3
Present on all T cells
a/w TCR- responsible for intracellular signal transduction
CD4
Present on helper T cells
Interacts w/ MHC II
CD8
Present on cytotoxic T cells
Interacts w/ MHC I
CD28
Present on all Th cells and 50% of Tc cells
Recieves costimulatory signal from B7 on APC's
CTLA-4
aka CD152
Present on activated T cells
Inhibis the T cell when bound to B7 from APC's
LFA-1
Present on all leukocytes
Binds to ICAM-1/CD54
CD40
Present on all B cells
Signals for isotype switching when bound to CD40L on activated Th cells
What complement?
Viral neutralization
C1,C2,C3,C4
What complement?
Opsonization
C3b
What complement?
Anaphylaxis
C3a,C5a
What complement?
Neutrophil chemotaxis
C5a
What complement?
Forms MAC
C5b-C9
What hypersensitivity rxn?
Anaphylaxis
Type I Hypersensitivity rxn
What hypersensitivity rxn?
Asthma
Type I Hypersensitivity rxn
What hypersensitivity rxn?
Hives
Type I Hypersensitivity rxn
What hypersensitivity rxn?
Local wheal & flare
Type I Hypersensitivity rxn
What hypersensitivity rxn?
Allergic rhinitis
aka Hay fever
Type I Hypersensitivity rxn
What hypersensitivity rxn?
Hay fever
aka allergic rhinitis
Type I Hypersensitivity rxn
What hypersensitivity rxn?
ABO incompatibility
Type II Hypersensitivity rxn
What hypersensitivity rxn?
Rh incompatibility
Type II Hypersensitivity rxn
What hypersensitivity rxn?
Hemolytic anemia
Type II Hypersensitivity rxn
What hypersensitivity rxn?
Goodpasture's syndrome
Type II hypersensitivity
What hypersensitivity rxn?
Myasthenia gravis
Type II hypersensitivity
What hypersensitivity rxn?
Thrombocytopenic purpura
Type II hypersensitivity
What hypersensitivity rxn?
Rheumatic fever
Type II hypersensitivity
What hypersensitivity rxn?
Bullous pemphigoid
Type II hypersensitivity
What hypersensitivity rxn?
Graves disease
Type II hypersensitivity
What hypersensitivity rxn?
Arthrus reaction
Type III hypersensitivity
What hypersensitivity rxn?
Farmer's Lung
aka aspergillus
Type III hypersensitivity
What hypersensitivity rxn?
Cheesemakers lung
Type III hypersensitivity
What hypersensitivity rxn?
Pigeon fanciers disease
Type III hypersensitivity
What hypersensitivity rxn?
Serum sickness
Type III hypersensitivity
What hypersensitivity rxn?
Rheumatoid arthritis
Type III hypersensitivity
What hypersensitivity rxn?
Lupus
Type III hypersensitivity
What hypersensitivity rxn?
Polyarteritis nodosum
Type III hypersensitivity
What hypersensitivity rxn?
Post-steptococcal GN
Type III hypersensitivity
What hypersensitivity rxn?
Hypersensitivity pneumonitis
Type III hypersensitivity
What hypersensitivity rxn?
Type I Diabetes
Type IV hypersensitivity
What hypersensitivity rxn?
Multiple Sclerosis
Type IV hypersensitivity
What hypersensitivity rxn?
Guillain-Barre syndrome
Type IV hypersensitivity
What hypersensitivity rxn?
Hashimoto's Thyroiditis
Type IV hypersensitivity
What hypersensitivity rxn?
Transplant rejections
Type IV hypersensitivity
What hypersensitivity rxn?
PPD skin test
Type IV hypersensitivity
What hypersensitivity rxn?
Contact dermatitis
Type IV hypersensitivity
Hypersensitivity where IgE crosslinking on presensitized mast cells & basophils by antigen releases vasoactive mediators
Type I hypersensitivity
Hypersensitivity where Ab's bind to cell surface antigens causing lysis or phagocytosis
Type II hypersensitivity
Hypersensitivity where antigen & antibody bind in serum, activate complement
Type III hypersensitivity
Hypersensitivity where sensitized T cells encounter antigen & release lymphokines activating macrophages
Type IV hypersensitivity
What is Type I hypersensitivity?
Anaphylactic and Atopic
IgE crosslinking on presensitized mast cells & basophils by antigen releases vasoactive mediators
What is Type II hypersensitivity?
Cytotoxic rxn/Ab mediated
Ab's bind to cell surface antigens causing lysis or phagocytosis
What is Type III hypersensitivity?
Immune complex rxns
Antigen & antibody bind in serum, activate complement
What is Type IV hypersensitivity?
Delayed(T cell mediated) type
Sensitized T cells encounter antigen & release lymphokines activating macrophages
ANA
Antinuclear antibody
a/w SLE
Anti-dsDNA
Anti double stranded DNA
a/w SLE (more specific than ANA)
Anti-Smith
a/w SLE (more specific than ANA)
Anti-histone
a/w Drug-induced lupus
Anti-IgG
aka Rheumatoid factor
a/w Rheumatoid arthritis
C-ANCA
Antineutrophil cytoplasmic Ab
a/w Vasculitis
P-ANCA
Antineutrophil cytoplasmic Ab
a/w Vasculitis
Anticentromere
a/w Scleroderma (CREST)
Anti-Scl-70
a/w Scleroderma (Diffuse)
Antimitochondrial
a/w Primary Biliary cirrhosis
Antigliadin
a/w Celiac's disease
Anti-basement membrane
a/w Goodpasture's syndrome
Anti-epithelial cell
a/w Pemphigus vulgaris
Antimicrosomal
a/w Hashimoto's thyroiditis
Anti-Jo-1
a/w Polymyositis & dermatomyositis
HLA a/w :
Psoriasis
HLA-B27
HLA a/w :
Ankylosing spondylitis
HLA-B27
HLA a/w :
Inflamatory bowell disease
HLA-B27
HLA a/w :
Reiter's syndrome
HLA-B27
HLA a/w :
Grave's disease
HLA-B8
HLA a/w :
Celiac Sprue
HLA-B8 & DR3
HLA a/w :
Multiple Sclerosis
HLA-DR2
HLA a/w :
Hay fever
HLA-DR2
HLA a/w :
SLE
HLA-DR2 & DR3
HLA a/w :
Goodpasture's
HLA-DR2
HLA a/w :
DM type I
HLA-DR3 & HLA-DR4
HLA a/w :
Rheumatoid arthritis
HLA-DR4
HLA a/w :
Pernicious anemia from B12 deficiency
HLA-DR5
HLA a/w :
Hashimoto's thyroiditis
HLA-DR5
HLA a/w :
Steroid responsive nephrotic syndrome
HLA-DR7
HLA a/w :
Narcolepsy
HLA-DR2
HLA a/w :
Pemphigus vulgaris
HLA-DR4
HLA a/w :
More severe arthritis post-Lyme disease infection
HLA-DR4
HLA a/w :
Hemochromatosis
HLA-A3