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110 Cards in this Set
- Front
- Back
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IL-1
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Endogenous pyrogen
Stimulates T cells, B cells, neutrophils, fibroblasts & epithelial cells |
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IL-2
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Stimulates T cells and enhances activity of NK cells
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IL-3
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Stimulates bone marrow stem cells
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IL-4
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Enhances class switching to IgE
Stimulates B cells and mast cells |
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IL-5
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Enhances class switching to IgA
Stimulates eosinophils & enhances IL-2 receptor expresion |
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IL-6
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Stimulates production of acute-phase reactants & Ig's
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IL-7
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Stimulates pre-B and pre-T cells
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IL-8
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Major chemotactic factor for neutrophils
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IL-9
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T-cell mitogen
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IL-10
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Stimulates Th2 while inhibiting Th1
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IL-11
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Stimulates hematopoeisis & enhances acute-phase protein synthesis
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IL-12
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Activates NK cells & Th1 cells
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IL-13
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Inhibits inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, MCP)
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IL-15
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T-cell mitogen & enhances growth of intestinal epithelium
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IL-16
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Increases class II MHC, chemotaxis & Th cell cytokines
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IL-17
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Increases the inflammatory response
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IL-18
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Increases IFN-gamma production & NK cell action
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IFN-alpha
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Inhibits viral replication
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IFN-beta
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Inhibits viral replication
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IFN-gamma
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Stimulates macrophages, Increases expression of MHC II's on APC's, antiviral properties, inhibits IL-4 activation of mast cells & IgE synthesis
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TNF-alpha
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Tumor necrosis factor-alpha
Attracts & activates neutrophils, Cytotoxic to tumors, stimulates dendritic cell migration to lymph nodes, increases IL-2 receptor synthesis in Th cells |
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TNF-beta
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Tumor necrosis factor-alpha
cytotoxic for tumors |
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TGF-beta
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Transforming growth factor-B
inhibits proliferation of B&T cells, reduces cytokine receptors, potent chemotactic agent for leukocytes, Mediates inflammation & tissue repair |
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CD2
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Present on peripheral T cell
Ligand is (LFA-3/CD58) |
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CD3
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Present on all T cells
a/w TCR- responsible for intracellular signal transduction |
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CD4
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Present on helper T cells
Interacts w/ MHC II |
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CD8
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Present on cytotoxic T cells
Interacts w/ MHC I |
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CD28
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Present on all Th cells and 50% of Tc cells
Recieves costimulatory signal from B7 on APC's |
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CTLA-4
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aka CD152
Present on activated T cells Inhibis the T cell when bound to B7 from APC's |
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LFA-1
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Present on all leukocytes
Binds to ICAM-1/CD54 |
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CD40
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Present on all B cells
Signals for isotype switching when bound to CD40L on activated Th cells |
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What complement?
Viral neutralization |
C1,C2,C3,C4
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What complement?
Opsonization |
C3b
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What complement?
Anaphylaxis |
C3a,C5a
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What complement?
Neutrophil chemotaxis |
C5a
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What complement?
Forms MAC |
C5b-C9
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What hypersensitivity rxn?
Anaphylaxis |
Type I Hypersensitivity rxn
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What hypersensitivity rxn?
Asthma |
Type I Hypersensitivity rxn
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What hypersensitivity rxn?
Hives |
Type I Hypersensitivity rxn
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What hypersensitivity rxn?
Local wheal & flare |
Type I Hypersensitivity rxn
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What hypersensitivity rxn?
Allergic rhinitis |
aka Hay fever
Type I Hypersensitivity rxn |
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What hypersensitivity rxn?
Hay fever |
aka allergic rhinitis
Type I Hypersensitivity rxn |
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What hypersensitivity rxn?
ABO incompatibility |
Type II Hypersensitivity rxn
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What hypersensitivity rxn?
Rh incompatibility |
Type II Hypersensitivity rxn
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What hypersensitivity rxn?
Hemolytic anemia |
Type II Hypersensitivity rxn
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What hypersensitivity rxn?
Goodpasture's syndrome |
Type II hypersensitivity
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What hypersensitivity rxn?
Myasthenia gravis |
Type II hypersensitivity
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What hypersensitivity rxn?
Thrombocytopenic purpura |
Type II hypersensitivity
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What hypersensitivity rxn?
Rheumatic fever |
Type II hypersensitivity
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What hypersensitivity rxn?
Bullous pemphigoid |
Type II hypersensitivity
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What hypersensitivity rxn?
Graves disease |
Type II hypersensitivity
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What hypersensitivity rxn?
Arthrus reaction |
Type III hypersensitivity
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What hypersensitivity rxn?
Farmer's Lung |
aka aspergillus
Type III hypersensitivity |
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What hypersensitivity rxn?
Cheesemakers lung |
Type III hypersensitivity
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What hypersensitivity rxn?
Pigeon fanciers disease |
Type III hypersensitivity
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What hypersensitivity rxn?
Serum sickness |
Type III hypersensitivity
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What hypersensitivity rxn?
Rheumatoid arthritis |
Type III hypersensitivity
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What hypersensitivity rxn?
Lupus |
Type III hypersensitivity
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What hypersensitivity rxn?
Polyarteritis nodosum |
Type III hypersensitivity
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What hypersensitivity rxn?
Post-steptococcal GN |
Type III hypersensitivity
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What hypersensitivity rxn?
Hypersensitivity pneumonitis |
Type III hypersensitivity
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What hypersensitivity rxn?
Type I Diabetes |
Type IV hypersensitivity
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What hypersensitivity rxn?
Multiple Sclerosis |
Type IV hypersensitivity
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What hypersensitivity rxn?
Guillain-Barre syndrome |
Type IV hypersensitivity
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What hypersensitivity rxn?
Hashimoto's Thyroiditis |
Type IV hypersensitivity
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What hypersensitivity rxn?
Transplant rejections |
Type IV hypersensitivity
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What hypersensitivity rxn?
PPD skin test |
Type IV hypersensitivity
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What hypersensitivity rxn?
Contact dermatitis |
Type IV hypersensitivity
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Hypersensitivity where IgE crosslinking on presensitized mast cells & basophils by antigen releases vasoactive mediators
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Type I hypersensitivity
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Hypersensitivity where Ab's bind to cell surface antigens causing lysis or phagocytosis
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Type II hypersensitivity
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Hypersensitivity where antigen & antibody bind in serum, activate complement
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Type III hypersensitivity
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Hypersensitivity where sensitized T cells encounter antigen & release lymphokines activating macrophages
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Type IV hypersensitivity
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What is Type I hypersensitivity?
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Anaphylactic and Atopic
IgE crosslinking on presensitized mast cells & basophils by antigen releases vasoactive mediators |
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What is Type II hypersensitivity?
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Cytotoxic rxn/Ab mediated
Ab's bind to cell surface antigens causing lysis or phagocytosis |
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What is Type III hypersensitivity?
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Immune complex rxns
Antigen & antibody bind in serum, activate complement |
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What is Type IV hypersensitivity?
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Delayed(T cell mediated) type
Sensitized T cells encounter antigen & release lymphokines activating macrophages |
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ANA
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Antinuclear antibody
a/w SLE |
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Anti-dsDNA
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Anti double stranded DNA
a/w SLE (more specific than ANA) |
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Anti-Smith
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a/w SLE (more specific than ANA)
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Anti-histone
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a/w Drug-induced lupus
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Anti-IgG
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aka Rheumatoid factor
a/w Rheumatoid arthritis |
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C-ANCA
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Antineutrophil cytoplasmic Ab
a/w Vasculitis |
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P-ANCA
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Antineutrophil cytoplasmic Ab
a/w Vasculitis |
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Anticentromere
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a/w Scleroderma (CREST)
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Anti-Scl-70
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a/w Scleroderma (Diffuse)
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Antimitochondrial
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a/w Primary Biliary cirrhosis
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Antigliadin
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a/w Celiac's disease
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Anti-basement membrane
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a/w Goodpasture's syndrome
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Anti-epithelial cell
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a/w Pemphigus vulgaris
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Antimicrosomal
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a/w Hashimoto's thyroiditis
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Anti-Jo-1
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a/w Polymyositis & dermatomyositis
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HLA a/w :
Psoriasis |
HLA-B27
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HLA a/w :
Ankylosing spondylitis |
HLA-B27
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HLA a/w :
Inflamatory bowell disease |
HLA-B27
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HLA a/w :
Reiter's syndrome |
HLA-B27
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HLA a/w :
Grave's disease |
HLA-B8
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HLA a/w :
Celiac Sprue |
HLA-B8 & DR3
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HLA a/w :
Multiple Sclerosis |
HLA-DR2
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HLA a/w :
Hay fever |
HLA-DR2
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HLA a/w :
SLE |
HLA-DR2 & DR3
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HLA a/w :
Goodpasture's |
HLA-DR2
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HLA a/w :
DM type I |
HLA-DR3 & HLA-DR4
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HLA a/w :
Rheumatoid arthritis |
HLA-DR4
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HLA a/w :
Pernicious anemia from B12 deficiency |
HLA-DR5
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HLA a/w :
Hashimoto's thyroiditis |
HLA-DR5
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HLA a/w :
Steroid responsive nephrotic syndrome |
HLA-DR7
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HLA a/w :
Narcolepsy |
HLA-DR2
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HLA a/w :
Pemphigus vulgaris |
HLA-DR4
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HLA a/w :
More severe arthritis post-Lyme disease infection |
HLA-DR4
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HLA a/w :
Hemochromatosis |
HLA-A3
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