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25 Cards in this Set
- Front
- Back
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Primary lymphoid organs
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Bone Marrow
Thymus |
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Secondary lymphoid organs
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Spleen
Lymph nodes MALT (GALT+BALT) |
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Types of dendritic cells
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Interdigitating dendritic cells - APC, have B7 molecule always ready to activate naive T cells - will eventually migrate to tissue, look for antigen, when they find antigen get to lymphatics and present it to T cell
FDC - follicular dendritic cells - not classic dendritic cells - NOT APC's, do not have MHC - trap antigen and antigen can stick to FDC - forms immune complexes and help in formation of memory and plasma cells |
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Afferent lymphatics
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From tissues to lymph nodes
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B cells are in which part of lymph node? T cells in which part of lymph node?
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B cells = cortex
T cells = para cortex |
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When lymph node proliferates its called _ , if gets really big its called _
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Secondary follicle
Germinal center |
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What is happening in germinal center
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-T cells and B cells interacting
-B cells undergoing somatic hypermutation and class switching -Making high affinity Ab's and differentiating into plasma cells |
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Describe lymph node cortex
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- Composed of primary follicles containing small resting B cells and follicular dendritic cells
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Describe lymph node paracortex
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- Primarily T cells and IDC
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Describe lymph node medulla
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- Plasma cells secreting antibody
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Spleen
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- Large encapsulated organ in left abdominal cavity
- Not supplied by lymphatic vessels - Antigens are carried in by splenic artery - Blood borne antigens go through spleen - Red and white pulp - white pulp is compartmentalized - B and T cells |
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B cells are found in which part of spleen
T cells are in which part of spleen |
Marginal zone
PALS - periarteriolar lymphoid sheath |
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What allows naive T cells to get to lymph nodes
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High endothelial venule - find on circulatory vesicles in lymph nodes
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Cell adhesion molecules
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- Selective gateways to lymphoid organs
- Organize traffic through secondary lymphoid tissue - CAM's on lymphocytes recognize CAM's on endothelial cells |
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Leukocyte adhesion defficiency
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Immune system sends effectors to the area but they cannot stop and adhere to the area - bacteria gets in, initiate inflammatory response - cannot adhere to vascular endothelium, still get vascular permeability, still see edema, but no pus - VERY HIGH WHITE CELL BLOOD COUNT - recurrent bacterial infections
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MALT
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- Diffuse collections of lymphocytes, plasma cells and phagocytes
- Found in lung and intestine - Tonsils, appendix, peyers patches - Large amounts of IgA |
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Why IgA can survive in mucus
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IgA secreted as dimer - binds to receptor - steals receptor - becomes secretory piece and protects igA from enzymatic degradation
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Lamina propria has high concentration of _ cells
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CD4
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Cytokines exxhibit_
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- Pleiotropy
- Redundancy - Synergy - Antagonism |
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Name pyrogenic cytokines
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IL1
IL6 TNF alpha |
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TNF alpha is made by _
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macrophages
T cells fibroblasts |
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TNF beta is made by _
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activated B cells and T cells
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When TNF alpha binds what happens
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either undergo apoptosis or activate transcription factor for signaling cascade
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TNF alpha inhibitors used to treat_
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RA
Psoriasis Crohns |
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Side effect of anti TNF alpha
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Increased susceptibility to disease
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