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25 Cards in this Set

  • Front
  • Back
Primary lymphoid organs
Bone Marrow
Secondary lymphoid organs
Lymph nodes
Types of dendritic cells
Interdigitating dendritic cells - APC, have B7 molecule always ready to activate naive T cells - will eventually migrate to tissue, look for antigen, when they find antigen get to lymphatics and present it to T cell

FDC - follicular dendritic cells - not classic dendritic cells - NOT APC's, do not have MHC - trap antigen and antigen can stick to FDC - forms immune complexes and help in formation of memory and plasma cells
Afferent lymphatics
From tissues to lymph nodes
B cells are in which part of lymph node? T cells in which part of lymph node?
B cells = cortex

T cells = para cortex
When lymph node proliferates its called _ , if gets really big its called _
Secondary follicle
Germinal center
What is happening in germinal center
-T cells and B cells interacting
-B cells undergoing somatic hypermutation and class switching
-Making high affinity Ab's and differentiating into plasma cells
Describe lymph node cortex
- Composed of primary follicles containing small resting B cells and follicular dendritic cells
Describe lymph node paracortex
- Primarily T cells and IDC
Describe lymph node medulla
- Plasma cells secreting antibody
- Large encapsulated organ in left abdominal cavity
- Not supplied by lymphatic vessels
- Antigens are carried in by splenic artery
- Blood borne antigens go through spleen
- Red and white pulp - white pulp is compartmentalized - B and T cells
B cells are found in which part of spleen
T cells are in which part of spleen
Marginal zone
PALS - periarteriolar lymphoid sheath
What allows naive T cells to get to lymph nodes
High endothelial venule - find on circulatory vesicles in lymph nodes
Cell adhesion molecules
- Selective gateways to lymphoid organs
- Organize traffic through secondary lymphoid tissue
- CAM's on lymphocytes recognize CAM's on endothelial cells
Leukocyte adhesion defficiency
Immune system sends effectors to the area but they cannot stop and adhere to the area - bacteria gets in, initiate inflammatory response - cannot adhere to vascular endothelium, still get vascular permeability, still see edema, but no pus - VERY HIGH WHITE CELL BLOOD COUNT - recurrent bacterial infections
- Diffuse collections of lymphocytes, plasma cells and phagocytes
- Found in lung and intestine
- Tonsils, appendix, peyers patches
- Large amounts of IgA
Why IgA can survive in mucus
IgA secreted as dimer - binds to receptor - steals receptor - becomes secretory piece and protects igA from enzymatic degradation
Lamina propria has high concentration of _ cells
Cytokines exxhibit_
- Pleiotropy
- Redundancy
- Synergy
- Antagonism
Name pyrogenic cytokines
TNF alpha
TNF alpha is made by _
T cells
TNF beta is made by _
activated B cells and T cells
When TNF alpha binds what happens
either undergo apoptosis or activate transcription factor for signaling cascade
TNF alpha inhibitors used to treat_
Side effect of anti TNF alpha
Increased susceptibility to disease