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86 Cards in this Set

  • Front
  • Back
what part of lymph node is deficient in DiGeorge's syndrome?
paracortex
what does the medullary sinus of a lymph node contain?
reticular cells and macrophages
what does the medullary cord contain?
lymphocytes and plasma cells
in the spleen, T cells are found in...
periarterial lymphatic sheath
red pulp
white pulp of the spleen contains..
B cells
Hassall's corpuscles are found in..
medulla of thymus
macrophage signals ______ to a naive T cell
macrophage is activated by____
IL-12
interferon gamma
what cytokine activates CD8 cells?
what else does it do?
IL-2
activate helper T cells
MHC I loading occurs in ___________
MHC II loading occurs in _________
RER
acidified endosome
what are the class I MHC genes?
A, B, C
what is the CD3 complex? What does it do?
associated with TCR
signal transduction
what co-stim molecule is on the APC?
One the T cells?
B7
CD28
what part of the antibody molecule fixes complement?
constant part of H chain of IgM and IgG
what antibodies fix complement?
IgM
IgG
what does terminal deoxynucleotidyl transferase do?
add nucleotides to DNA in antibody diversity
what does complement do?
enhance opsonization
lysis
what enables isotype switching?
CD40 ligand on Th cells
most abundant Ig in serum?
least abundant?
IgG
IgE
what Ig does a mature B cell express on surface?
IgM
IgD
_______ crosses placenta
_______ doesn't cross placenta
IgG
IgM
what does IL-12 do?
activate Th1 cells
activate NK cells
who secretes IL-12?
B cells and macrophages
who makes IL-10?
Th2 cells
which interleukin is a chemotactic factor for neutrophils?
IL-8
what does IL-6 do?
stimualate acute phase reactants and immunoglobulins
who makes TNF-alpha?
macrophages
macrophages have receptors for...
Fc
C3b
CD14 on _________
CD16 on _________
macrophages
NK cells
what cells don't have MHCI?
RBCs
complement defends against __________
gram negative bacteria
what activates complement in the alternative pathway?
molecules on surface of microbes (espeically endotoxin)
deficiency of __________ leads to Neisseria infection
C6-C8
what does C3 deficiency cause?
recurrent pyogenic sinus and respiratory infections with Staph
PNH is caused by deficiency of ______, which normally inhibits _________
DAF
C3 or C5 convertase
what does C1 esterase deficiency cause?
hereditary angioedema
C3a and C5a are for...
also known as...
anaphylaxis
anaphylotoxin I and II
what opsonizes?
C3b
C2 and C4 deficiency manifest as...
lupus-like autoimmune disease
what is the C3 convertase of the classic and lectin pathways?
C4b,2b
what is the C3 convertase of the alternative pathway?
C3b,Bb
what is the most common complement deficiency?
C2
what do interferons do?
anti-viral state
what does interferon gamma do?
activate macrophages
increase Class I and II expression
how do interferon alpha and beta inhibit viral protein synthesis?
degrade viral mRNA
what bugs do antigenic variation?
Salmonella
Borellia
Gonococcus
Trypanosomes
what do immune complexes in Type III do?
activate complement, which attracts neutrophils,
who release lysosomal enzymes
how long does serum sickness take to develop?
5 days
how is type II cytotoxic?
lysis via MAC
what do sensitized T cells in type IV do?
encounter antigen and then release lymphokines
disseminated mycobacterial infections?
IL-12 receptor deficiency
inability to mount IgM response to capsular polysaccarides?
Wiscott-Aldrich
X-linked?
Bruton's agammaglobulinemia
Wiscott-Alrdrich
Chronic granulomatous disease
IL-12 receptor SCID
failure of interferon-gamma?
Job's syndrome
eczema, coarse facies, retained primary teeth?
Job's syndrome
(also high IgE)
delayed separation of the umbilicus?
leukocyte adhesion deficiency syndrome
opportunistic infections?
chronic granulomatous disease
staph/strep infections, partial albinism, peripheral neuropathy?
Chediak Higashi disease
most common selective Ig deficiency?
IgA
defects and deficiency in ataxia-telangiectasia?
DNA repair enzymes
IgA deficiency
anti-mitochondrial antibodies?
primary biliary cirrhosis
anti-epithelial cell antibodies?
pemphigus vulgaris
time course for acute rejection?
weeks
time course for chronic rejection?
months-years
how do you reverse acute rejection?
cyclosporin, OKT3
mechanism of chronic rejection?
anti-body mediated vascular damage
cytotoxic T cells mediate ________ rejection
acute
decreased LAP?
CML
PNH
anti-smooth muscle antibody?
autoimmune hepatitis
how do you treat hyper IgM syndrome?
pooled gamma globulin
what does deficiency of tyrosine kinase ZAP70 cause?
SCID
measels results in ________ deficiency
T cell
what immune deficiency predisposes to non-Hodgkin lymphoma?
Wiscott-Aldrich
how does Epi treat anaphylaxis?
increased cAMP prevents mast cell degranulation and bronchial constriction
what acitvates NK cells to kill?
interferon
what is lectin?
a microbial surface antigen
what is C3 nephritic factor?
what disease?
IgG to C3 convertase, prevents inactivation
Type II membranoproliferative GN
what is an LAK cell?
NK cell activated by IL-2
cell surface receptor for EBV?
CD21
unique to polysaccaride antigens?
just IgM, no class-switching
what stimulates dendritic cell migration?
TNF-alpha
what does IL-12 do?
activate NK and Th cells
what is unique about IgM production?
doesn't require Th cells
what is perforin?
made by CD8 cells
major determinants of organ rejection?
MHC Class II
what cytokines do Th2 cell secrete?
IL-4,5,6,10
what Ig are low after splenectomy?
IgG2
IgM