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21 Cards in this Set
- Front
- Back
IgG
|
most abundant antibody (75%),
responsible for 2° response monomer, fixes complement, opsonizes pathogens only antibody that crosses placenta |
|
IgA
|
found in mucosal secretions
dimer |
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IgM
|
also found on B cell surface,
responsible for 1° response pentamer, fixes complement, opsonizes indirectly by stimulating C3b |
|
IgE
|
least common antibody,
mediates type I hypersensitivity, targets worms cross-links and stimulates mast cells |
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IL-1
|
secreted by macrophages
causes fever stimulates: T cells, B cells, neutrophils, fibroblasts, epithelial cells |
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IL-2
|
secreted by Th-1 cells
stimulates: Th-1 cells, CD8 cells |
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IL-4
|
secreted by Th-2 cells
stimulates: B cell growth, Th-2 cell growth, IgE switching |
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IL-5
|
secreted by Th-2 cells
stimulates: IgA switching, eosinophils |
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IL-6
|
secreted by Th-2 cells & macrophages
stimulates: B cell differentiation; liver to release acute phase proteins |
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IL-10
|
secreted by Th-2 cells
stimulates: Th-2, inhibits Th-1 by limiting γ-IFN |
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IL-12
|
secreted by macrophages
stimulates: Th-1 cells |
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Th-1 cells
|
manage cell-mediated response
secrete γ-IFN, which stimulates antigen presentation and thus CD8 cells & macrophages stimulated by IL-12 from macrophages |
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Th-2 cells
|
manage humeral response
secrete IL-4 & IL-5 to stimulate T cells and B cells stimulated by IL-4 from other Th-2 cells (and from mystery cell) |
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complement components that
mediate slow-response to anaphylaxis |
C3a, C5a
|
|
complement component
that opsonizes |
C3b
|
|
complement component
that attracts neutrophils |
C5a
|
|
complement components responsible
for membrane attack complex |
C5b, C6, C7, C8, C9
|
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Type I hypersensitivity
|
anaphylactic, atopic
antigen cross-links IgE on sensitized mast cells/basophils causing histamine release examples: anaphylaxis, hay fever |
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Type II hypersensitivity
|
cytotoxic / antibody-mediated
IgM, IgG bind antigen on foreign cell, leading to lysis via complement examples: hemolytic anemia, ideopathic thrombocytopenic purpura, rheumatic fever, Goodpasture's, bullous pempigoid, Grave's, myasthenia gravis |
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Type III hypersensitivity
|
immune complex
complexes activate compliment, which attracts neutrophils, which damage tissue examples: lupus, RA, polyarteritis nodosum, post-strep glomerulonephritis, serum sickness, Arthus reaction, hypersensitivity pneumonitis |
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Type IV hypersensitivity
|
delayed (T-cell mediated)
sensitized T cells release IL-12 to activate macrophages example: TB PPD, graft vs. host, contact dermatitis, type 1 DM, MS, Guillain-Barré, Hashimoto's |