Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
What are the 3 pathways of complement activation?
|
1. The Classical Pathway - triggered by antibodies that bind pathogens
2. The Alternative Pathway - antibody independent pathway in which complement activation is amplified on microbial surfaces 3. The Mannose Binding Lectin Pathway - Antibody independent, recognizes a microbial surface feature |
|
|
What are the 3 major functions of complement?
|
1. Opzonization and phagocytocis
2. Stimulation of inflammatory reactions 3. Complement-mediated cytolysis |
|
|
What is the common complement effector molecule used by all 3 complement pathways?
|
C3b
|
|
|
Will soluble IgM/IgG or Antigen Bound IgM/IgG cause complement activation?
|
Antigen Bound
|
|
|
What activates the Alternative Pathway?
|
C3b binding directly to microbial cell walls
|
|
|
What activates the Classical Pathway?
|
C1 binding to antigen-antibody complexes
|
|
|
What does C1 bind to?
|
2 adjacent IgG antibodies that are bound to microbial surface
|
|
|
What do complement proteins create on the membrane of a microbe that allows for cytolysis?
|
The Membrane Attack Complex (MAC) which creates pore in membrane that causes microbe to lyse
|
|
|
What type of bond links C3 fragments to bacteria surface proteins and sugars?
|
Thioester mediated covalent bond
|
|
|
What are the 3 categories of complement regulatory proteins?
|
1. C1 inhibition - C1INH
2. Proteins that inhibit C3 convertase (DAF) 3. Proteins that inhibit the MAC (CD59 and plasma s protein) |
|
|
What molecule inhibits C1?
|
C1INH
|
|
|
What inhibits C3 convertase?
|
DAF (Decay Accelerating Factor) that is present on normal cells
|
|
|
What protein inhibits MAC formation on normal cells?
|
CD59 and plasma S protein
|
|
|
Absence of functional DAF will give what condition?
|
Paroxysmal nocturnal hemoglobinuria (wake up at night and pee blood)
|
|
|
Deficiency in C1INH is associated with what disease?
|
Angioneurotic Edema
|
|
|
Deficiency of CD59 leads to what?
|
Hemolytic anemia and strokes
|
