Immunology 02: Avni

Front 1

macrophages do ___ phagocytosis and ___ antigen presentation. dendritic cells do ___ phagocytosis and ___ antigen presentation.

Back 1

peripheral
peripheral
peripheral
lymph nodal

Front 2

MQs use ___ (5) receptors for eating pathogens. eating them triggers ___

Back 2

mannose
CD14 (LPS)
TLR4 (also LPS)
scavenger
glucan
cytokine release

Front 3

APCs display degraded cytosolic proteins on ___ to ___ cells

Back 3

MHC I
CD8

Front 4

APCs display degraded endosomal proteins on ___ to ___ cells

Back 4

MHC II
CD4

Front 5

T/F: RBCs express MHC I

Back 5

false

Front 6

because of ___, MHC I is expressed on most ___ cells

Back 6

they are susceptible to viral infection
nucleated

Front 7

MHC II is expressed by (3)

Back 7

DCs
B cells
macrophages

Front 8

MHC I has ___ domains, designated ___. Ag is displayed in cleft between ___ and ___. ___ is bound noncovalently and is not encoded in MHC locus. ___ spans the membrane.

Back 8

3
alpha1
alpha2
alpha3
alpha1
alpha2
beta2 microglobulin
alpha3

Front 9

MHC II has ___ domains on ___ chains. The chains are designated ___. Ag is displayed in cleft between ___ and ___. ___ span the membrane.

Back 9

4
2
alpha
beta
alpha1
beta1
alpha2
beta2

Front 10

NK cells bind MHC I with ___. if ___ is present on a cell without ___, NK cell will attack.

Back 10

inhibitory receptor
activating ligand
MHC I

Front 11

Ii is aka ___. its primary purpose is ___. it also ___s. after partial degradation it is called ___. it is knocked out of the groove by ___.

Back 11

invariant chain
occupy peptide-binding groove on MHC II till it's ready to bind Ag
targets MHC II to endosome
CLIP
HLA-DM

Front 12

TCR is composed of ____ chains. it complexes with ___, which is composed of ____ chains. It also complexes with a ___ homodimer

Back 12

alpha
beta
CD3
gamma
delta
2 epsilon
zeta

Front 13

first step in TCR production is ___. it is done when the cell is at ___ stage.

Back 13

beta chain recombination
CD44 low, CD25+

Front 14

once TCRbeta chain complexes with ___, ___ stops. the complex is called ___, and the cell does ___ (2).

Back 14

pTalpha
beta chain recombination
pre-TCR
proliferates
expresses CD3, CD4, CD8
starts TCRalpha recombination

Front 15

TCR alpha rearrangement is done by ___ cells

Back 15

CD4+CD8+

Front 16

the TCRalpha-beta-CD3 complex is first expressed at the ___ stage

Back 16

DP

Front 17

AIRE is primarily transcribed in ___, especially ___ cells. defects in it cause ___ aka ___

Back 17

lymphoid organs
thymic epithelial
APECED
APS I

Front 18

as thymic epithelial cells mature they move from ___ to ___. as they mature expression of AIRE ___s.

Back 18

cortex
medulla
rises

Front 19

APCs use ___ for co-stimulation of ___ T cells. This occurs in ___.

Back 19

B7
naive
lymph nodes

Front 20

B7 interacts with ___ on the T cell.

Back 20

CD28

Front 21

in response to costimulation from Ag on MHC, ___ and ___, T cells express ___.

Back 21

CD4 or CD8
B7
CD40L

Front 22

cross-priming allows ___ by ___

Back 22

non-infected APCs to stimulate CD8 T cells
allowing endocytosed viral Ags onto MHC I

Front 23

TCR/MHC/co-receptor interaction causes ___ of ITAMs by ___.

Back 23

phosphorylation
Lck

Front 24

Lck activates ___, which activates ___s, e.g. ___.

Back 24

ZAP70
TRAP
LAT

Front 25

LAT activates ___, which causes intracellular ___. this activates ___ via ___.

Back 25

PLC gamma
Ca2+ relase
NFAT
calcineurin

Front 26

cyclosporin A is immunosuppressive because

Back 26

it blocks NFAT activation by calcineurin

Front 27

main cytokine from TH1 cell

Back 27

IFNgamma

Front 28

main cytokine from TH2 cell

Back 28

IL-4

Front 29

main cytokine from TH17 cell

Back 29

IL-17

Front 30

main cytokine from THr cell

Back 30

TGFbeta

Front 31

AID is ___. it does ___ in B cells

Back 31

activation-induced cytidine deaminase
somatic hypermutation

Front 32

ADCC is ___. it refers to the ability of ___ cells to ___ cells which are ___.

Back 32

antibody-dependent cell-mediated cytotoxicity
NK
kill non-phagocytotically
covered in Abs

Front 33

TAP preferentially transports peptides of length ___ with ___ or ___ residues at carboxy end. ___ has the same AA specificity.

Back 33

8-16
hydrophobic
basic
MHC I

Front 34

MHC-related response to IFNgamma (5)

Back 34

MHC I, II upregulation
costimulatory ligand upregulation
TAP upregulation
immunoproteasome formation
PA28 synthesis

Front 35

CMV US6 causes ___. CMV US2, 11 cause ___. CMV US3 causes ___.

Back 35

TAP inhibition
MHC I translocation to cytosol and degradation
inhibition of MHC I shipping to membrane

Front 36

part of MHC I homologous with Ig heavy chain constant region

Back 36

beta2 microglobulin

Front 37

part of MHC II homologous with Ig heavy chain constant region

Back 37

both chains

Front 38

___ cells in the brain express MHC II

Back 38

microglia

Front 39

T/F: human T cells express MHC II

Back 39

true

Front 40

MHC II wants a ___ 5 residues after a ___ (2)

Back 40

aliphatic or hydroxyl
D or E

Front 41

MHC loci are on chromosome ___. loci for MHC I are called ___ (3). loci for MHC II are called ___ (3).

Back 41

6
HLA A-C
HLA DP, DQ, DR

Front 42

HLAs associated with DM I

Back 42

DR3
DR4