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7 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What is the function of antibody?
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Bind Antigen- in a few cases this has a direct effect (e.g. neutralizing bacterial toxin or by preventing viral penetration of cells
Activation of secondary effector functions (e.g. complement, phagocytes) is needed to clear the pathogen |
two functions
bind What? activate of what? |
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What is the definition of antibody?
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Isotype- constant region of heavy chain
(a) IgG, IgM, IgA, IgD, or IgE Idiotype- variable region of light & heavy chains (Idiotype is the structure that interacts with the antigen) |
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What are the main charisteristics of IgG?
Serum conc. Serum half life Antibacterial lysis Antiviral activity complement fixation placental transfer location |
Serum conc.
Serum half life 600-1200 Antibacterial lysis 23 Antiviral activity + complement fixation + placental transfer + location serum, amniotic fluid |
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What are the main charisteristics of IgA?
Serum conc. Serum half life Antibacterial lysis Antiviral activity complement fixation placental transfer location |
Serum conc. 140-260
Serum half life- 6 Antibacterial lysis- + Antiviral activity-(best compared to other isotype) complement fixation- none (0) placental transfer- no location- serum, colostrum, GI & Respiratory tracts, salvia, tears location |
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What are the main characteristics of IgM?
Serum conc. Serum half life Antibacterial lysis Antiviral activity complement fixation placental transfer location |
Serum conc. - 70-120
Serum half life - 5 days Antibacterial lysis - best compared to other isotypes Antiviral activity - + complement fixation - (++++) best compared to other isotypes placental transfer- no location- serum, membrane receptor on b-lymphs |
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What are the characteristics of IgD?
Serum conc. ? Serum half life ? antibacterial lysis ? Antibiral activity? complement fixation? Placental transfer? location? |
Serum conc. 0.3 - 30
Serum half life 3 days antibacterial lysis unsure Antibiral activity? unsure complement fixation? (0) none Placental transfer? no location? serum, membrane receptor on B-lymphs |
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What are the characteristics of IgE?
Serum conc. ? Serum half life ? antibacterial lysis ? Antibiral activity? complement fixation? Placental transfer? location? |
Serum conc. - 0.002-0
Serum half life - 2 days antibacterial lysis - unknown Antibiral activity - unknown complement fixation - 0 Placental transfer - no location - serum |
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