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7 Cards in this Set

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What is the function of antibody?
Bind Antigen- in a few cases this has a direct effect (e.g. neutralizing bacterial toxin or by preventing viral penetration of cells

Activation of secondary effector functions (e.g. complement, phagocytes) is needed to clear the pathogen
two functions
bind What?
activate of what?
What is the definition of antibody?
Isotype- constant region of heavy chain
(a) IgG, IgM, IgA, IgD, or IgE

Idiotype- variable region of light & heavy chains
(Idiotype is the structure that interacts with the antigen)
What are the main charisteristics of IgG?
Serum conc.
Serum half life
Antibacterial lysis
Antiviral activity
complement fixation
placental transfer
location
Serum conc.
Serum half life 600-1200
Antibacterial lysis 23
Antiviral activity +
complement fixation +
placental transfer +
location serum, amniotic fluid
What are the main charisteristics of IgA?
Serum conc.
Serum half life
Antibacterial lysis
Antiviral activity
complement fixation
placental transfer
location
Serum conc. 140-260
Serum half life- 6
Antibacterial lysis- +
Antiviral activity-(best compared to other isotype)
complement fixation- none (0)
placental transfer- no
location- serum, colostrum, GI & Respiratory tracts, salvia, tears
location
What are the main characteristics of IgM?
Serum conc.
Serum half life
Antibacterial lysis
Antiviral activity
complement fixation
placental transfer
location
Serum conc. - 70-120
Serum half life - 5 days
Antibacterial lysis - best compared to other isotypes
Antiviral activity - +
complement fixation - (++++) best compared to other isotypes
placental transfer- no
location- serum, membrane receptor on b-lymphs
What are the characteristics of IgD?
Serum conc. ?
Serum half life ?
antibacterial lysis ?
Antibiral activity?
complement fixation?
Placental transfer?
location?
Serum conc. 0.3 - 30
Serum half life 3 days
antibacterial lysis unsure
Antibiral activity? unsure
complement fixation? (0) none
Placental transfer? no
location? serum, membrane receptor on B-lymphs
What are the characteristics of IgE?
Serum conc. ?
Serum half life ?
antibacterial lysis ?
Antibiral activity?
complement fixation?
Placental transfer?
location?
Serum conc. - 0.002-0
Serum half life - 2 days
antibacterial lysis - unknown
Antibiral activity - unknown
complement fixation - 0
Placental transfer - no
location - serum