Immunoglobulin Class Switching

Front 1

What is the basic principles to immunoglobulin class switching

Back 1

1) during an immune response B cells will sometimes switch and mae a different class of antibody
-V regions remain the same but C regions change
-Different classes of antibodies work in different parts of the body (blood versus mucous secretion)
-Switch in undirectional ( B cell that switches from IgM -> IgG will never make IgM again)
-T helper cells induce class switching via cytokines

Front 2

What is a more sosphicated understanding of immuoglobulin class switching?

Back 2

In secondary responses, plasma cell secrete antibodies that still have same antigen specificty as IgM on surface of the original cell that was activated and the IgM that was secreted int he primary response
-However antibodies secreted during secondary response now have different H chain constant region,
-Antibodies produced during a secondary resposne are mostly IgG instead of IgM

Front 3

What induces ics?

Back 3

Activated T helper cells release cytokines that have been shown to induce B cells to class switch to a particular class of antibody

-IL-4 induces class switching to TgG or TgE
IL-5 induces class switching to IgA