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40 Cards in this Set
- Front
- Back
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What happens in chemotaxis: a function of complement
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C5 attracts and activates neutrophils and mast cells and results in inflammation
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phagocytes fail to produce reactive oxygen species due to an enzymatic defect; therefore intracellular microbes are not destroyed
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phagocytic cell defects; Immunodeficiency
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what causes phagocytic cell defects
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deficiency of complement, especially C1, C2, and C4 Immunodeficiency
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Agannaglobuinemia or hypogammaglobuinemia ;Immunodeficiency
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B cell deficiency;Immunodeficiency
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the inability of B cells to produce viable antibodies;Immunodeficiency
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B cell deficiency;Immunodeficiency
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Developmental failure to the thymus results in few of these and causes poor cell mediated immunity
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T cell Deficiency;Immunodeficiency
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Combined immunodeficiency
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lack of enzymes that produce T cell and B cell receptors leads to combined immunodeficiency: rapidly fatal if deficiency is severe
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What is acquired immunodeficiency
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deficiency due to virus, exposure to certain chemicals or radiation
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hypersensitivity
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over reaction of the immune response to antigen, it should protect the host but in this case may result in injury.
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smooth muscle contraction and vascular permeability increase dramatically
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Type I hypersensitivity
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Hemolytic disease of the newborn or drug allergies
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Type II hypersensitivity
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an antibody dependent cytotoxic hypersensitivity in which any cell coated with antibody will be attacked and destroyed by killer cells
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Type II hypersensitivity
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An immediate reaction in which IgE coated mast cells release vasoactive amines
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Type I hypersensitivity
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during what hypersensitivity state is histamine, leukotrienes and prostaglandins secreted
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Type I hypersensitivity
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Immune complex present on tissues causes activation of complement, thus damage to surrounding tissues
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Type III hypersensitivity
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glomerulonephritis is caused by this type of hypersensitivity
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Type III hypersensitivity
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antibody coated bacterial antigens lodge on the basement membrane of the glomerulus causing damage
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glomerulonephritis
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A delayed hypersensitivity manifested by a cell mediated response
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Type IV hypersensitivity
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antigen activated T cells recruit macrophages and basophils to tissues where present
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Type IV hypersensitivity
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Usually within 24 to 72 hours this hypersensitivity occurs
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Type IV hypersensitivity
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autoimmune disease
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the immune response mounts attack against the host (self) tissues
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what is Hashimoto's thyroiditis
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organ specific autoimmune disease in which a pathology results from antibodies generated against thyroid tissue
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What is systemic lupus erythematosis (SLE)
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a non organ specific autoimmune systemic disease that affects the entire body with no one specific organ involved
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Name the primary test for syphilis
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RPR Test
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what is RPR
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rapid plasmin reagin
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during syphilis infection the patient produces antibodies to what?
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lipid cellular debris (AKA: Plasmin reagin)
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what specifically does RPR test for
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plasmin reagin
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Why must all positive RPR test be confirmed
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because other disease states may cause a positive result
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What test is used to confirm a positive RPR test
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FTA ABS (fluorescent treponemal antibody absorption test)
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this test is useful as a screening procedure and for monitoring treatment of syphilis
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RPR Test
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autoimmune disease
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the immune response mounts attack against the host (self) tissues
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what is Hashimoto's thyroiditis
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organ specific autoimmune disease in which a pathology results from antibodies generated against thyroid tissue
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What is systemic lupus erythematosis (SLE)
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a non organ specific autoimmune systemic disease that affects the entire body with no one specific organ involved
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Name the primary test for syphilis
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RPR Test
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what is RPR
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rapid plasmin reagin
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during syphilis infection the patient produces antibodies to what?
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lipid cellular debris (AKA: Plasmin reagin)
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what specifically does RPR test for
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plasmin reagin
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Why must all positive RPR test be confirmed
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because other disease states may cause a positive result
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What test is used to confirm a positive RPR test
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FTA ABS (fluorescent treponemal antibody absorption test)
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this test is useful as a screening procedure and for monitoring treatment of syphilis
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RPR Test
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