Immuno Vocab 7

Front 1

affinity maturation

Back 1

the consequence of genetic mutations in the hypervariable region following B cell activation and isotype switching

Front 2

anti-idiotype antibodies

Back 2

antibodies that are directed to the hypervariable regions of the light and heavy chains

Front 3

Btk kinase

Back 3

a tyrosine kinase required for B cell development; its genetic deficiency leads to X-linked agammaglobulinemia

Front 4

CD19

Back 4

surface molecule of B cells that can be used as a panmarker for enumeration or identification of B cells

Front 5

CD2

Back 5

a molecule present on T cells and NK cells; used as a panmarker for T cells with contaminating NK cells

Front 6

CD40-CD40L

Back 6

CD40 is present on B cells and other APCs; CD40L present on T cells

Front 7

CD45

Back 7

a tyrosine phosphatase

Front 8

CD79a/79b

Back 8

molecules that are expressed in association with mIg on the surface of B cells

Front 9

class II MHC

Back 9

molecules that present antigen to CD+ T cells

Front 10

clonal expansion

Back 10

sequential binary division of a cell following appropriate stimulation

Front 11

FcγRIII

Back 11

a low affinity receptor for the Fc region of IgG

Front 12

follicles

Back 12

region of immune tissues in which B cells predominate

Front 13

GAP

Back 13

GTPase activating protein
results in inactivation of GTP by converting it to GDP

Front 14

germinal center

Back 14

region of the follicle in which B cells undergo proliferation and other differentiation events following activation

Front 15

GEF
guanine exchange factor

Back 15

exchanges GDP with GTP

Front 16

HEV
high endothelial venules

Back 16

venules in lymph nodes -- sites at which lymphcytes leave the blood and enter lymph nodes

Front 17

hyper IgM syndrome

Back 17

defect in CD40-CD40L interxn usually from deficiency of CD40L on T-cells

Front 18

hypogammaglobulinemia

Back 18

decreased levels of abs in serum

Front 19

ICAM

Back 19

counter molecule for the adhesion molecule LFA-1

Front 20

isotype switching

Back 20

causes expression of IgG, IgA, or IgE on activated B cell surfaces, instead of IgM and IgD

Front 21

L selectin

Back 21

molecule on lymphocytes that interacts w/counter molecules on HEV to induce rolling of lymphcytes

Front 22

LFA-1

Back 22

leukocyte function associated antigen - 1
adhesion molecule present on many cells including B and T cells that binds to ICAM

Front 23

LFA-3

Back 23

adhesion molecule binds to CD2

Front 24

LPS
lipopolysaccharide

Back 24

at high concentration, LPS is a polyclonal activator of B cells

Front 25

memory cells

Back 25

differentiated lymphocytes that are not destroyed following B cell or T cell activation; plays role of immunosurveillance

Front 26

mIg

Back 26

B cell receptor, membrane immunoglobulin, cell surface antibodies

Front 27

pneumococcal polysaccharide

Back 27

T independent antigen, also component of a capsule surrounding some bacteria

Front 28

primary immune response

Back 28

immune response following first exposure to antigen

Front 29

secondary immune response

Back 29

immune response following subsequent exposure to antigen

Front 30

somatic mutation

Back 30

mutations occurring in the DNA encoding the hypervariable region following B cell activation

Front 31

switch recombination

Back 31

process following B cell activation in which the DNA of some constant regions is excised, resulting in isotype switching

Front 32

T-dependent antigen

Back 32

antigen in which B cells can only respond if T cells deliver the appropriate signals

Front 33

T-independent antigen

Back 33

antigen in which B cells can be activated in the absence of cognate interxn with T cells

Front 34

transient hypogammaglobulinemia of infancy

Back 34

transient deficiency in serum antibodies

Front 35

x-linked agammaglobulinemia
x-linked hypogammaglobulinemia
Bruton's agammaglobulinemia

Back 35

immunodeficiency disorder resulting from a defect in Btk kinase