Immuno Vocab 5

Front 1

alternative pathway of complement

Back 1

pathway initiated by C3b, associated with innate immunity

Front 2

anaphylatoxin

Back 2

C3a, C4a, C5a; binding to their receptors on mast cells and basophils induces cell degranulation

Front 3

anaphylatoxin inhibitor

Back 3

protein that inactivates the anaphylatoxins

Front 4

Ba and Bb

Back 4

proteolytic fragments of Factor B following cleavage by Factor D; Bb forms part of the AP C3 convertase

Front 5

C1 INH
C1 inhibitor protein

Back 5

protein that binds to C1 preventing its activation (C1 cleaves C4 and C2)

Front 6

C1 through C9

Back 6

proteins of the classical pathway

Front 7

C2b

Back 7

proteolytic fragment of C2 that is also a weak kinin (increases vascular permeability)

Front 8

alternative pathway C3 convertase

Back 8

C3bBb

Front 9

classical pathway C3 convertase

Back 9

C4b2a

Front 10

C3 tickover

Back 10

refers to the spontaneous production of C3b which activates complement AP

Front 11

C3a, C4a, C5a

Back 11

proteolytic fragments of C3, C4, C5, respectively that are also anaphylatoxins

Front 12

C3b

Back 12

an opsonin that activates AP; a component of both AP and CP

Front 13

C4bp

Back 13

a regulatory protein that binds C4b, preventing its attachment to cells and also promotes the dissociation of AP C3 convertase

Front 14

AP C5 convertase

Back 14

C3bBbC3b

Front 15

CP C5 convertase

Back 15

C4b2a3b

Front 16

CD59

Back 16

MAC inhibitor

Front 17

classical pathway of complement

Back 17

pathway initiated by IgM or IgG immune complexes

Front 18

CR1

Back 18

complement receptor 1 for C3b

Front 19

CR2

Back 19

complement receptor 2 for C3bi

Front 20

CR3a/4a

Back 20

complement receptor for anaphylatoxins C3a and C4a

Front 21

DAF
decay accelerating factor

Back 21

prevents formation of, or causes dissociation of C3 convertases by binding to C4b and C3b

Front 22

CR5a

Back 22

complement receptor of the anaphylatoxin C5a

Front 23

Factor B

Back 23

binds to deposited C3b

Front 24

Factor D

Back 24

enzyme that cleave bound Factor B

Front 25

Factor H

Back 25

binds C3b which prevents binding of Factor B to C3b and causes dissociation of C3bBb

Front 26

Factor I

Back 26

regulatory protein that cleaves soluble forms of C3b and C4b in the presence of one of several cofactors

Front 27

GPI
glycosyl-phosphatidyl-inositol

Back 27

molecule that serves to attach some proteins to the cell in lieu of a transmembrane domain

Front 28

HAE
hereditary angioedema

Back 28

complement disorder caused by genetic deficiency of C1 INH

Front 29

HRF
homologous restriction factor

Back 29

MAC inhibitor

Front 30

kallikrein

Back 30

formed during intrinsic coagulation pathway activation

Front 31

kininogen

Back 31

cleaved by kallikrein to create bradykinin

Front 32

MAC
membrane attack complex

Back 32

complex made up of C5b, C6, C7, C8, and C9; inserts into membranes to induce cell lysis

Front 33

Neisseria species

Back 33

MAC protein deficiencies (esp. C8) results in recurrent infections with these particular bacterial species

Front 34

paroxysmal nocturnal haemoglobulinuria

Back 34

genetic disorder that manifests as hemolytic anemia due to defect in GPI linkages

Front 35

properdin

Back 35

protein that stabilizes AP C3 convertase

Front 36

S protein

Back 36

MAC inhibitor

Front 37

terminal pathway

Back 37

convergence of AP and CP leading to MAC formation

Front 38

vitronectin

Back 38

MAC inhibitor

Front 39

xenograft

Back 39

graft from another species