Immuno Vocab 3

Front 1

allele

Back 1

one of two or more variations of a gene present at a specific locus

Front 2

CD4+ T cells

Back 2

T cells responsible for cytokine secretion

Front 3

CD8+ T cells

Back 3

T cells responsible for cytotoxicity

Front 4

class I MHC
major histocompatibility complex class I

Back 4

proteins present on all nucleated cell surfaces; w/in the protein groove sits antigenic fragments

Front 5

class I MHC restriction

Back 5

refers to the fact that antigenic receptors on CD8+ T cells can only recognize antigenic fragments displayed via class I MHC

Front 6

class II MHC
major histocompatibility complex class II

Back 6

proteins present on all APC surfaces; w/in the protein groove sits antigenic fragments

Front 7

class II MHC restriction

Back 7

refers to the fact that antigenic receptors on CD4+ T cells can only recognize antigenic fragments displayed via class II MHC

Front 8

codominant expression

Back 8

the expression of both alleles of a gene

Front 9

costimulatory molecules

Back 9

molecules that are required for activation of some cells

Front 10

endosome

Back 10

a vacuole that is formed w/in the cytosol

Front 11

HLA
human leukocyte antigens

Back 11

alias for human MHC

Front 12

Ii
invariant chain

Back 12

a protein that is the same in all cells; blocks class II MHC antigen-binding sitein the ER

Front 13

polymorphism

Back 13

occurrence of multiple alleles of a gene within a population; happens with MHC

Front 14

professional APC

Back 14

cells whose primary role is to present antigen to T cells

Front 15

proteasome

Back 15

complex of proteolytic enzymes that degrade ubiquitin-bound cytosolic proteins

Front 16

TAP
transporter of antigen processing

Back 16

proteins used to transport peptides degraded by proteosome into the ER

Front 17

β-2 microglobulin

Back 17

invariant chain of class I MHC