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20 Cards in this Set
- Front
- Back
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IL-1
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Secreted by m'phages: pyrogen, activates endothelium to express adhesion molecules, chemokine secretion to recruit leukocytes, osteoclast stimulation
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IL-6
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Secreted by m'phages, Th2: pyrogen, stimulates osteoclasts
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IL-8
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Secreted by m'phages: PMN chemotactic factor
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IL-12
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Secreted by m'phages, B: induces differentiation of T cells into Th1; activates NK cells
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TNF-alpha
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secreted by m'phages: septic shock, activates endothelium, causes leukocyte recruitment, vascular leak
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IL-3
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Secreted by T-cells; supports growth and differentiation of bone marrow cells, functions like GM-CSF
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IL-2
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secreted by Th1 cells: stimulates growth of Th and Tc cells
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IFN-gamma
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secreted by Th1 cells: activates m'phages and Th1 cells, suppresses Th2 cells, antiviral and antitumor properties
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IL-4
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secreted by Th2 cells; induces differentiation into Th2 cells; promotes growth of B cells, enhances class switching to IgE and IgG
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IL-5
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Secreted by Th2 cells: promotes differentiation of B cells, enhances class switching to IgA, stimulates eosinophils
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IL-10
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secreted by Th2 cells, Regulatory cells; inhibits actions of activated T cells and Th1; activates Th2
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all interferons
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activate NK cells to kill virus-infected cells; produce ribonuclease
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IFN-alpha, IFN-beta
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inhibit viral protien synthesis, produce antiviral proteins
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Cell surface markers: T cells (all)
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CD3, CD 28, CD7, TCF
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Cell surface markers: Th cells
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CD4, CD40L
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Cell surface marker: Tc cells
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CD8
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Cell surface markers: B cells
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CD 19, CD 20, CD 21, CD 40, B7, MHC II, Ig
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Cell surface markers: Macrophages
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MHC II, B7, CD40, CD14, Fc and C3b receptors
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Cell surface markers: NK cells
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Receptors for MHC I, CD 16, CD56
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Cell surface marker: all cells except mature red cells
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MHC I
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