Immuno Quizzes Plus Cytokines

Front 1

down regulates IL-12 which leads to down regulation of Th1 cytokines

Back 1

IL-10

Front 2

Amplification factor for Th17

Back 2

IL-21

Front 3

Down regulation of iNOS

Back 3

IL-10, IL-4, TGFbeta (BEST)

Front 4

induces fever

Back 4

IL-1 & TNF together

Front 5

enhances NADPH oxidase activity

Back 5

TNF, IFNgamma

Front 6

stimulates IFNgamma secretion from NK cells

Back 6

IL-12

Front 7

growth factor for T cells

Back 7

IL-2

Front 8

activation of eosinophils

Back 8

IL-5

Front 9

role in production of protective enzymes that interfere with viral replication

Back 9

IFN alpha/beta

Front 10

Important for myeloid and lymphoid pathways

Back 10

IL-3

Front 11

Secreted by Th17

Back 11

IL-17A, IL-17F, IL-21, IL-22

Front 12

shifts Th0 --> Th2

Back 12

IL-4

Front 13

isotype switching of IgE

Back 13

IL-4

Front 14

CRP secretion is stimulated by

Back 14

IL-6

Front 15

down regulates Type 1 cytokine secretions

Back 15

IL-4, IL-10

Front 16

chemotactic for eosinophils

Back 16

IL-5, Eotaxin (CCL11)

Front 17

enhances NK cell cytotoxicity

Back 17

IL-2

Front 18

secreted by macrophages

Back 18

cytokines: IL-1 + TNF, IL-6, IL-12, IL-23, CSF
chemokines:IL-8, MCP-1

Front 19

activates macrophage to secrete cytokines and chemokines

Back 19

IL-1 & TNF together

Front 20

role in pCTL--> CTL differentiation

Back 20

IL-2 & IFNgamma

Front 21

activates iNOS

Back 21

TNF, INFgamma

Front 22

Th0--> Th17 differentiation

Back 22

IL-6 & TGFbeta together
OR
IL-21 & TGFbeta together

Front 23

T cell development in thymus

Back 23

IL-7

Front 24

Prominflammatory

Back 24

IL-22

Front 25

Th0-->Th1 differentiation

Back 25

IFNgamma, IL-12

Front 26

de novo expression of ICAM-1, VCAM-1 and E-selectin

Back 26

IL-1 & TNF together

Front 27

Th17 cell inhibition

Back 27

IL-2

Front 28

inhibition of T cell proliferation

Back 28

IFNalpha/beta

Front 29

induce expression of metalloproteinases from macrophages

Back 29

IL-17A/F

Front 30

enhances expression of Class I MHC on nucleated cells or Class II MHC on APCs

Back 30

IFNgamma

Front 31

down regulates production of Th2 cytokines

Back 31

IFNgamma (directly),
IL-12 --> activates NK cells to secrete INFgamma (indirectly)

Front 32

Th0--> a/I Tregs differentiation

Back 32

TGFbeta

Front 33

GM progenitor cell --> neutrophil

Back 33

G-CSF

Front 34

Molecular Interactions:
CD 2

Back 34

LFA-3

effect is adhesion

Front 35

increases expression of Class I MHC on nucleated cells

Back 35

IFNalpha/beta AND IFNgamma

Front 36

secreted from mast cells

Back 36

IL-4, IL-5

Front 37

secreted by NK cells

Back 37

IFNgamma

Front 38

secreted by dendritic cells

Back 38

IL-12, IL-23

Front 39

chemotactic for neutrophils
what is the other name for the chemokine?

Back 39

IL-17a, IL-8

CXCL8

Front 40

chemotactic for monocytes

Back 40

MCP-1 (CCL2)

Front 41

Molecular Interactions:

L-selectin has what effect?
what cell is it expressed on?

Back 41

rolling (counter molecule depends)
T cell

Front 42

Molecular Interactions:

on APC: ICAM-1, ICAM-2
list effect and counter molecule on T cell (has 2 names)

Back 42

firm adhesion
T cell: LFA-1 (CD11a & CD18)

Front 43

Molecular Interactions:

P-selectin, list cell location and effect

induced by?

Back 43

(counter molecule depends) Activated Vascular Epithelium
rolling

histamine induced

Front 44

Molecular Interactions:

E-selectin, list cell and effect
Induced by?

Back 44

Activated Vascular Epithelium (APC)
Effect: rolling
induced by: TNF & IL-1

Front 45

Molecular Interactions:
For the T cell: APC interaction below, what is the effect and what induces it? List the alternate name for LFA-1.

LFA-1: ICAM-1

Back 45

Firm Adhesion
induced by: TNF & IL-1
LFA-1= CD11a & CD18

Front 46

Molecular Interactions:
Mac-1 (integrin heterodimer) is on the T cell. List its alternate name, molecule(s) it interacts with and effect

Back 46

Mac -1 = CD11b & CD18
counter molecule: ICAM-1
effect: Firm Adhesion

Front 47

Molecular Interactions:
PE-CAM interacts with what? What effect?

Back 47

PE-CAM
Adhesion for transmigration

Front 48

Molecular Interactions:

CD40L (CD154)

Back 48

CD40
Isotype switching

Front 49

Molecular Interactions:

CD28

Back 49

CD 28 on T cell : CD80 & CD 86 (B7-1 & B7-2) - on APC

effect: Costimulation and enhanced transcription + stabilization of IL-2

Front 50

Molecular Interactions:
CD4

Back 50

MHC Class II
costimulation

Front 51

Molecular Interactions:
CD8

Back 51

MHC Class I
costimulation

Front 52

Molecular Interactions:
VLA-4

Back 52

VCAM-1
Firm Adhesion

Front 53

List the B cell stage:
Tolerance Induction

Back 53

Immature B cell

Front 54

List the B cell stage:
CD19

Back 54

Pro B cell -->

Front 55

List the B cell stage:
Allelic exclusion

Back 55

Pre-B cell

Front 56

List the B cell stage:
Somatic recombination

Back 56

Pre-B cell

Front 57

List the B cell stage:
Alternative splicing

Back 57

Mature Naive B cell

Front 58

List the B cell stage:
TDT

Back 58

Pro- B cell

Front 59

List the B cell stage:
Somatic mutation

Back 59

Activated B cell

Front 60

List the B cell stage:
CD 20

Back 60

Pre-B cell -->

Front 61

List the B cell stage:
BCR (sIgD) + (sIgM)

Back 61

Mature Naive B cell

Front 62

List the B cell stage:
CD 40

Back 62

Mature naive B cell

Front 63

List the B cell stage:
Rag-1, Rag-2

Back 63

Pro-B cell

Front 64

List the B cell stage:
Alternative Splicing

Back 64

Mature naive B cell

Front 65

List the B cell stage:
BCR (sIgM)

Back 65

Immature B cell

Front 66

List the B cell stage:
Affinity maturation

Back 66

Activated B cell

Front 67

List the B cell stage:
Isotype switching

Back 67

Activated B cell

Front 68

Complement:
S-protein

Back 68

MAC inhibitor (terminal pathway)

Front 69

Complement:
C5b,6,7,8,9

Back 69

MAC complex

Front 70

Complement:
3a,5a

Back 70

anaphylatoxins-both pathways

Front 71

Complement:
Factor H

Back 71

regulator of Alternative Pathway (C3 convertase)

Front 72

Complement:
Properdin

Back 72

stabilizes C3 convertase (alternative pathway)

Front 73

Complement:
C3b

Back 73

generated from C3 in spontaneous tickover, important in both pathways (part of the C5 convertases)

Front 74

Complement:
Vitronectin

Back 74

MAC inhibitor (terminal pathway)

Front 75

Complement:
AI

Back 75

anaphylatoxin inhibitor (regulator of both pathways)

Front 76

Complement:
DAF

Back 76

decay accelerating factor (regulator of both pathways- C3 convertase)

Front 77

Complement:
Cleaves C3

Back 77

C3 convertase (both pathways)

Front 78

Complement:
Factor B

Back 78

CBb (Alternative pathway)

Front 79

Complement:
C3bBb

Back 79

C3 convertase (Alternative pathway)

Front 80

Complement:
HRF

Back 80

homologous restriction factor- MAC inhibitor (Terminal pathway)

Front 81

Complement:
Factor D

Back 81

CBb (alternative pathway)

Front 82

Complement:
C4bp

Back 82

Factor I cofactor- regulator of Classical Pathway (C3 convertase)

Front 83

Complement:
Factor I

Back 83

regulator of both pathways (C3 covertase)

Front 84

Complement:
C4b2a

Back 84

C3 convertase (Classical Pathway)

Front 85

Complement:
CD59

Back 85

MAC inhibitor (Terminal pathway)

Front 86

Complement:
C4b2a3b

Back 86

C5 covertase (classical pathway)

Front 87

Complement:
C1 INH

Back 87

prevents Classical Pathway activation

Front 88

Complement:
4a

Back 88

anaphylatoxin- classical pathway only

Front 89

Complement:
Ligand fragments- C3b, C4b
receptor? cell type? function?

Back 89

binds to CR 1
phagocytes, erythrocytes
Oposin mediated recognition, clearance of immune complexes

Front 90

Complement:
ligand fragment- C3bi

binds to what receptor? cell type? function?

Back 90

CR2
B lymphocytes
possible mode of EBV infection

Front 91

Complement:
C3a, C4a
receptor? cell type? function?

Back 91

C3a/C4a-R
Mast cells, basophils
Degranulation (histamine)

Front 92

Complement:
C5a
binds to which receptor? cell types? function?

Back 92

C5A-R
Mast cells, basophils, endothelial cells, phagocytes
Increases vascular permeability, chemotaxis

Front 93

Antibodies:
Activates Complement - Classical Pathway

Back 93

IgM (most efficient) IgG

Front 94

Antibodies:
Activate Complement- Alternative Pathway

Back 94

IgA

Front 95

Antibodies:
Mucosal immunity

Back 95

IgA

Front 96

Antibodies:
Pentamer form

Back 96

IgM

Front 97

Antibodies:
helminth infections

Back 97

IgE

Front 98

Antibodies:
Oposinization

Back 98

IgG

Front 99

Antibodies:
breast milk and colostrum

Back 99

IgA (high concentrations), IgG

Front 100

Antibodies:
FcepsilonR on mast cells, basophils

Back 100

IgE

Front 101

Antibodies:
J chain

Back 101

IgA, IgM

Front 102

Antibodies:
ADCC

Back 102

IgG

Front 103

Antibodies:
longest half life

Back 103

IgG

Front 104

Antibodies:
primary immune response- first one secreted

Back 104

IgM

Front 105

Antibodies:
crosses the placenta

Back 105

IgG

Front 106

Antibodies:
Isohemagglutinin

Back 106

IgM

Front 107

Antibodies:
immature naive B cells

Back 107

IgM

Front 108

Antibodies:
allergies

Back 108

IgE

Front 109

Antibodies:
neutralizes viruses and toxins

Back 109

IgG

Front 110

Name the cell:
NADPH

Back 110

phagocyte

Front 111

Name the cell:
Lysosomal enzymes

Back 111

phagocyte

Front 112

Name the cell:
CD2

Back 112

T cell

Front 113

Name the cell:
CD3

Back 113

T cell

Front 114

Name the cell:
Opsonin

Back 114

phagocyte

Front 115

Name the cell:
LFA-3

Back 115

APC

Front 116

Name the cell:
ADCC

Back 116

NK cell

Front 117

Name the cell:
Major basic protein

Back 117

Eosinophil

Front 118

Name the cell:
ICAM-1

Back 118

APC

Front 119

Name the cell:
Histamine

Back 119

Mast cell

Front 120

Name the cell:
Microbial port of entry

Back 120

M cell

Front 121

Name the cell:
CD28

Back 121

T cell

Front 122

Name the cell:
Class II MHC

Back 122

APC

Front 123

Name the cell:
Inducible NO synthase

Back 123

phagocyte

Front 124

Name the cell:
CD 154 (CTLA-4)

Back 124

T cell

Front 125

Name the cell:
CD 8

Back 125

T cell subset

Front 126

Name the cell:
IFN gamma receptors

Back 126

NK cell, phagocyte

Front 127

Name the cell:
CD 80 & 86 (B7-1 & B7-2)

Back 127

APC

Front 128

Name the cell:
Perforin

Back 128

NK cell

Front 129

Name the cell:
Reactive oxygen intermediate

Back 129

phagocyte

Front 130

Name the cell:
CD 40L

Back 130

T cell

Front 131

Name the cell:
kills virally infected cells

Back 131

NK cell

Front 132

Name the cell:
engulfs viruses when outside of cell

Back 132

phagocyte

Front 133

Name the cell:
CD11a

Back 133

T cell

Front 134

Name the cell:
CD 18

Back 134

T cell

Front 135

Name the cell:
kills heminths

Back 135

Eosinophil

Front 136

Name the cell:
Fc epsilon receptor

Back 136

Mast cell, eosinophil

Front 137

Name the cell, counter cell, ligand and effect
CD 40

Back 137

CD 40 (APC): CD 40L (T-cell)
effect- Isotype Switching

Front 138

Name the cell:
engulfs bacteria outside of cell

Back 138

phagocyte

Front 139

Name the cell:
reactive oxygen intermediate

Back 139

phagocyte

Front 140

Complement:
C3b,Bb,3b

Back 140

5C convertase (alternative pathway)

Front 141

Complement:
C4b,2a

Back 141

3C convertase (classical pathway)

Front 142

T-Lymphocytes:
Name the pan marker

Back 142

CD2

Front 143

Lymphocyte Activation:

Low level LPS (lipopolysaccheride) generates what kind of immune response?

Monoclonal, Polyclonal or Oligoclonal

Back 143

Monoclonal - Type I
(T independent antigen)
--> IgM production

Front 144

Lymphocyte Activation:

Superantigens (like Toxic Shock toxin 1) generate what kind of immune response?

Monoclonal, Polyclonal or Oligoclonal

Back 144

Oligoclonal

Front 145

Lymphocyte Activation:

High concentration LPS (lipopolysaccheride) generates what kind of immune response?

Monoclonal, Polyclonal or Oligoclonal

Back 145

Polyclonal (B cell)

NOTE: this only happens in labs, not in nature

Front 146

Lymphocyte Activation:

Pneumococcal polysaccharide generates what kind of immune response?

Monoclonal, Polyclonal or Oligoclonal

Back 146

Monoclonal Type 2
--> isotype switching possible

Front 147

Lymphocyte Activation:

Lectins (Con A, PHA) generate what kind of immune response?

Monoclonal, Polyclonal or Oligoclonal

Back 147

Polyclonal (T cell)

NOTE: this only happens in labs, not in nature

Front 148

Lymphocyte Activation:

PWM (pokeweed mitogen) generates what kind of immune response?

Monoclonal, Polyclonal or Oligoclonal

Back 148

Polyclonal (B or T cell)

NOTE: this only happens in labs, not in nature

Front 149

T cell activation:

In the CD200:CD200R interaction, which molecule gets turned off?

Which T cell expresses higher amounts of the above?

CD4 or CD8

Back 149

CD200R --> suppression of T cell mediated immune responses

Memory CD4+ T cells express a higher amount of the receptor than either CD4+ T naive or effector cells and also more than CD8 + T cells

Front 150

Name the Type 1 cytokines

Back 150

IL-2, TNF, IFNgamma

Front 151

Name the Type 2 cytokines

Back 151

IL-4, IL-5, IL-6, IL-10, IL-13, TGFbeta

Front 152

Somatic Recombination is initiated by?

Back 152

RAG1, RAG2
(recombinating activating genes)

Front 153

T lymphocytes:
chain names and composition?

Back 153

alpha chain: V,J
beta chain: V,D,J

Front 154

B cells:
name the chain names and
composition?

Back 154

light chains (2): V,J
heavy chains (2): V,D,J

Front 155

MHC Complexes:
HLA (A,B,C)

Back 155

Class I MHC

Front 156

MHC Complexes:
Murines (K, D, L)

Back 156

Class I MHC

Front 157

MHC Complexes:
IFNgammaR

Back 157

Class II MHC

Front 158

MHC Complexes:
Beta2-microglobulin nonpolymorphic, on chromosome 15

Back 158

Class I MHC

Front 159

MHC Complexes:
codominantly expressed

Back 159

Both Class I and Class II MHC

Front 160

MHC Complexes:

expressed only on APCs

Back 160

Class II MHC

Front 161

MHC Complexes:

HLA-DR10

Back 161

Class II MHC

Front 162

MHC Complexes:

Ii (Invarient chain)

Back 162

Class II

Front 163

MHC Complexes:

Displays antigenic fragments destroyed by the proteosome

Back 163

Class I

Front 164

MHC Complexes:

Displays antigenic fragments destroyed within the phagolysome

Back 164

Class II

Front 165

MHC Complexes:

expressed on virtually all nucleated cells

Back 165

Class I

Front 166

MHC Complexes:

presents to CD4+ T cells

Back 166

Class II

Front 167

MHC Complexes:

presents to CD8+ T cells

Back 167

Class I

Front 168

MHC Complexes:

TAP (transporter of antigen binding)

Back 168

Class I

Front 169

MHC Complexes:

exogenous antigen processing, DM (another MHC encoded molecule)

Back 169

Class II

Front 170

MHC Complexes:

Virus that inhibits TAP-mediated translocation of peptides from cytosol into the ER

Back 170

Class I
HSV (herpes simplex virus)

Front 171

MHC Complexes:

Virus that inhibits the activity of the proteasomes

Back 171

Class I
EBV (Ebstein Barr virus)

Front 172

MHC Complexes:

Virus that hinders the expression of antigen peptide/MHC complex on the cell surface

Back 172

Class I

CMV (Cytomegaolvirus)

Front 173

MHC Complexes:

Cells that express CD1 molecules as antigen presenting molecules

Back 173

Dendritic cells

Front 174

Name the cell:

Most efficient APC?

Back 174

Dendritic cell

Front 175

Name the cell:

Most sensitive APC?

Back 175

B cell (prevails when antigen is limited, only need small amount)

Front 176

Name the cell:

Antigen presenting cell during seconday immune response?

Back 176

Macrophage

Front 177

Name the cell:

expresses chemokine receptors CCR5 and/or CXCR4

Back 177

Dendrites and Macrophages

Front 178

Name the cell:

nTregs

Back 178

CD4+, CD25+, FOXP3+

Front 179

Chemotactic for lymphocytes

Back 179

RANTES- regulated on activation, normal T cell expressed and secreted cytokine

Front 180

Molecular Interactions:

CD 80 & CD 86 (B7-1 & B7-2) are on the APC

List TWO possible interactions and effects

Back 180

on T cell
CD 28
Effect: Co-stimulation and IL-2 stabilization
-OR-
CD 152 (CTLA-4)
Effect: Down regulation of T cells

Front 181

Stabilization of Th17

Back 181

IL-23