Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
B cell |
- Antibody mediated immunity - Bone marrow - Stored in spleen |
|
|
T Cell |
- Cell mediated immunity - Thymus Normal Funct; 1. Receptor binding & signalling APC + HLA complex 2. Cell-cell signalling: surface interaction + secreted proteins 3. Autocrine signalling: IL-2 4. Proliferation |
|
|
T Cell Receptor |
- Binds HLA-antigen complex - Activates PLC gamma - Phosphatidyl inositol -> IP3 - Release Ca2+, activate calcineurin - Calcineurin dephos NF-AT& recruit Oct - NF-AT + Oct transcription factor for IL-2 with Rel-A and NF-kB |
|
|
Calcineurin
|
Phosphatase that removes phosphate from NF-AT & Oct |
|
|
Cyclosporin |
- Calcineurin inhibitor - Binds cyclophilin- inhibits - Fungal peptide - AUC predicts response and toxicity, but variable absorption - C2 better predictor than trough |
|
|
Tacrolimus |
- Calcineurin inhibitor - Binds immunophilin (FKBP) - Fungal macrolide - Long t1/2: trough C0 good measure |
|
|
Glucocorticoids |
1. Inhibits AP-1 directly 2. Increases transcription of I-kB, indirectly increases inhibition of NF-kB and Rel-A 3. Increases mRNA degradation |
|
|
mTOR |
- Mammalian target of rapamycin - Increase translation of mRNA for cell cycle proteins - Increase p27 degradation - Binds EIF-4E and 40-S subunit needed for translation |
|
|
p27 |
- Inhibits cyclin E, CDK2 complex - Inhibits during G0 and G1 |
|
|
Sirolimus |
- mTOR inhibitor - fungal macrolide - binds immunophilin - Long t1/2: trough C0 good measure |
|
|
Everolimus |
- mTOR inhibitor - fungal macrolide - binds immunophilin - Long t1/2: trough C0 good measure |
|
|
Mycophenolate |
- Funal - Inhbits IMP dehydrogenase - Inhibits de novo synthesis of guanosine monophosphate - G-MP needed in B and T cells for DNA & RNA synth and signalling - Glucuronidated in liver - Conc increases after 4 hours- recycle, more variable relationship b/w C0 and AUC |
|
|
Anti-CD3 antibody |
- Binds CD2 on T cell receptor - Prevents T cell from binding to APC - Apoptose? |
|
|
Eliminated by CYP3A4 |
Everolimus, tacrolimus, cyclosporin & sirolimus |
|
|
Substrates for p-gp |
Everolimus, tacrolimus, cyclosporin & sirolimus |
