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7 Cards in this Set
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- Back
- 3rd side (hint)
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AIRE gene
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Mechanism: failure of central tolerance
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Autoimmune polyendocrine syndrome (APS)
destruction of endocrine organs by Abs |
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C4
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defective clearance of immune complexes
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Systemic lupus erythematosus (SLE)
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CTLA-4
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Failure of anergy in CD4+ T cells
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T1D
Thryoid diseease Primary billary cirrhosis |
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Fas/FasL
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defective deletion of anergic self-reactive B cells
Reduced deletion of mature CD4+ cells |
Autoimmune lympho-proliferative syndrome (ALPS)
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FoxP3
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Deficiency of T regs
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immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)
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IL-2/IL-2Ralpha/beta
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defective development, survival or function of T regs
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None known
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SHP-1
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failure of negative regulation of B cells
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none known
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