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11 Cards in this Set
- Front
- Back
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IgG
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Most abundant Ig type in the serum
Sticks around the longest PLACENTA TRANSFER (protects fetus) -subtypes IgG1-4 Action is intravascular, interstitial, transplacental. |
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What determines the class of Antibody?
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The heavy chain determines the class of Ab.
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IgM
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-pentameric form; largest
-joined by J chain -FIRST produced in first immune response -intravascular action (stays in bloodstream) |
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IgA
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-Dimer formed by j chain.
-Secretory component -found in mucosal membranes, secretions, and breast milk. -predominates in breast milk, tears, saliva |
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IgD
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found on B cell surfaces as an antigen receptor
little is secreted. |
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IgE
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-ALLERGIC REACTIONS
-minute in serum unless during allergic rxns., parasitic infections, and asthma. -binds to mast cells to cause release of inflamm. mediators. -site of action is subq, submucosal. |
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Primary response
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-1 week lag phase
-slow increase -low plateau -low Ab affinity -IgM>IgG |
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Secondary Response
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-1 to 2 day lag phase
- Rapid rate of increase -high plateau -high affinity of Ab -IgG >IgM |
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Structure of an Immunoglobulin
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-4 polypeptide chains, 2 identical heavy and 2 identical light
-bilaterally symmetrical - 2 types of light chains (kappa and lambda); same on both sides of an Ig. |
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Where is the antigen binding site?
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Ag binding site is the hypervariable heavy chain and the light chain regions (the variable regions)
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More Ig structure description
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-has histamine residues
- lets the unit bend and flex -has Fab region where antigen binding site is -Fc is where the Ig binds to the surface of the phagocyte -The heavy chain determines the isotype of the Ig |
