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26 Cards in this Set
- Front
- Back
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Appreciate the speed and efficiency of bacterial metabolism and growth
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Grow more rapidly than eukaryotic cells b/c it's an amorphous matrix of ribosomes. No compartments.
-more diversity also -have just the right amount of building blocks to make macromolecules -don't accumulate toxic stuff -nothing unnecessary made |
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Explain how ATP and reducing power are generated
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Describe energy utilization in the bacterial cell
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f
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List the nutrient entry mechanisms
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Explain the differences between fermentation and respiration
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Describe binary fission
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Explain phases of growth in bacteria
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Describe nutrition including oxygen requirements
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List the steps in the synthesis of peptidoglycan
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List the common classes of antibiotics and their targets
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Bactoprenol phosphate
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transports the ppg across the cell membrane
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Autolysins
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break the glycosidic bonds of the ppg and peptide cross linkages
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Transglycosidase (TG)
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enzyme INSERT and LINKS monomoers into the new ppg
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Transpeptidase (TP)
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REFORMS the peptide cross links
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Name some B-lactams and what they do
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Penicillin, Cephalosporin, Carbepenem
bind to TRANSPEPTIDASE, preventing that last step |
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Vancomycin
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beinds to peptides of ppg monomers and BLOCK TRANSGLYCOSIDASE
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Bacitracin
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blocks dephosphorylation of BACTOPRENOL PHOSPHATE
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Cycloserine
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blocks addition of dipeptide of UDP-NAM
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Fosfomycin
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inhibits phosphoenopyruvate transfer and PREVENTS FORMATION OF NAM
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Linezolid
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blocks initiating complex
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Tetracycline and Aminoglycosides
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30s inhibitors
Tetra-Amino-30 |
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Macrolides and Chloramphenicol
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50s inhibitors
Mac-Chloro-50 |
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Name two drugs that block DNA synthesis
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Fluroquinolones and Metronidazole
FluMetro-DNA |
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RNA synthesis
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Rifampin
R-R |
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Folate Antagonists
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Trimethoprim, Sulfonamides
FATS |
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Cytoplasm membrane
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Polymyxins
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