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62 Cards in this Set

  • Front
  • Back
Upper limb & lateral breast drain to what LN?
Axillary
Stomach drains to what LN?
Celiac
Duodenum & jejunum drain to what LN?
Superior Mesenteric
Sigmoid colon drains to what LN?
Colic --> Inferior Mesenteric
Rectum (lower part), anal canal above pectinate line drain to what LN?
Internal iliac
Anal canal below pectinate line drains to what LN?
Superficial inguinal
Testes drain to what LN?
Superficial & deep plexuses --> para-aortic
Scrotum drains to what LN?
Superficial inguinal
Thigh drains to what LN?
Superficial inguinal
Lateral side of dorsum of foot drains to what LN?
Popliteal
ANA
SLE
anti-dsDNA, anti-Smith
Specific for SLE
Antihistone abs
Drug induced lupus
Anti-IgG (rheumatoid factor)
Rheumatoid arthritis
Anticentromere
Scleroderma (CREST)
Anti-Scl-70 (anti-DNA topoisomerase I)
Scleroderma (diffuse)
Antimitochondrial
primary biliary cirrhosis
Antigliadin, antiendomysial
Celiac disease
Anti-basement membrane
Goodpasture's Syndrome
Anti-desmoglein (desmosomes)
Pemphigus Vulgaris
Antimicrosomal, antithyroglobulin
Hashimoto's thyroiditis
Anti-Jo-1
Polymyositis, Dermatomyositis
anti-SSA (anti-Ro) & Anti-SS-B (anti-La)
Sjorgen's syndrome
Anti-U1 RNP (ribonucleoprotein)
Mixed CT disease
Anti-smooth muscle
Autoimmune hepatitis
Anti-glutamate decarboxylase
Type I DM
c-ANCA
Wegener's granulomatosis
p-ANCA
microscopic polyangiitis, churg strauss
MPO-ANCA
Pauci immune crescentic GN
anti-TSH
Graves disease
anti-Ach
Myasthenia Gravis
This cytokine is secreted by macs. Causes acute inflammation. Induces chemokine production to recruit leukocytes; activates endothelium to expression adhesion molecules. An endogenous pyrogen.
OT
IL-1
Secreted by Th1 cells. Stimulates growth of helper & cytotoxic T cells
IL-2
Secereted by activated T cells. Supports the growth & differentiation of BONE MARROW stem cells. Functions similar to GM-CSF
IL-3
Secreted by Th2 cells. Promotes growth of B cells. Enhances class switching IgE & IgG.
IL-4
Secreted by Th2 cells. Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates production and activation of EOSINOPHILS
IL-5
Secreted by Th cells & macs. Stimulates production of acute phase reactants & immunoglobulins
IL-6
Secreted by macs. Major chemotactic factor for neutrophils (as well as C5a
& LTNB4)
IL-8
Secreted by regulatory T cells. Inhibit actions of activated T cells. Activates Th1
IL-10
Secreted by B cells & macs. Activates NK & Th1 cells.
IL-12
Secreted by Th1 cells. Stimulates macs. Activates Th1, inhibits Th2
IFN-gamma
Secreted by macs. Mediates septic shock. Causes leaukocyte recruitment, vascular leak.
TNF
Cell surface receptors for Helper T cells
CD4, TCR, CD3, CD28, CD40L
Cell surface receptors for Cyotoxic T cells
CD8, TCR, CD3
B Cell cell surface receptors
IgM, CD19, CD20, CD21, CD40, MHC II, B7
Macrophages Cell surface receptors
MHC II, B7, CD40, CD14, Receptors for Fc & C3b
NK cell surface receptors
Receptors for MHC I, CD16 (binds Fc of IgG), & C3b
All cells except mature red cells
MHC I
CD55 & CD59 are located on
WBC, RBC, & platelets -- protect these cells from complement mediated damage
Diseases w/ increased ESR
polymyalgia rheumatica
temporal arteritis
disease activity RA & SLE
infection, inflammation (osteomyelitis)
malignancy
X-linked disease in boys
B cell deficiency --> defective TK gene --> low levels of all Ig's
Recurrent bacterial infections after 6m
Bruton's agammaglobulinemia
3rd & 4th pouches fail to develop --> no thymus --> no T cells & no PTH --> low Ca --> tetany (chvosteks & trousseau's)
Recurrent viral, fungal, protozoal infections
Congenital defects in heart/great vessels
90% chr 22q11 deletion
Thymic aplasia (DiGeorge)
Defect in early stem cell differentiation
ADA deficiency
Last defense is cytotoxic NK cells
Triad: severe recurrent infections, chronic diarrhea, FTT
No thymic shadow on newborn CXR
SCID
T cell dyxfxn v C. albicans
Rx: ketoconazole
Chronic Mucocutaneous Candidiasis
X-Linked immunodeficiencies
WBC:
Wiskott Aldrich
Bruton's agammaglobulinemia
Chronic granulomatous disease
Hyper-IgM syndromes
Immunodeficiency
Thrombocytopenia & purpura
Recurrent pyogenic infections
low IgM & high IgA
X Linked
Wiskott -Aldrich
IgA deficiency
Cerebellar ataxia & poor smooth pursuit of moving target w/ eyes
Telangiectasia of face >5 yo
Inc cancer riskL lymphoma & acute leukemias
Radiation sensitivity
+/- inc afp in kids >8 m
Ataxia telangiectasia
IgA deficiency
Recurrent sinus & lung infections
A/w atopy & asthma
Selevtive Ig Deficiency
Lack NADPH oxidase (impotent phagocytes)
Susceptible to CATALASE (+) organisms
Dx w/ nitroblue tetrazolium (NBT) dye --> no yellow to blue black oxidation
Chronic Granulomatous Disease
Defective LYST gene
Defective phagocyte lysosome
Dx: Giant cytoplasmic granules in PMNs
Triad: partial albinism, recurrent RTI & skin infections, neuro d/o
Chediak Higashi Disease
Hyper IgE
Deficient IFN gamma -- PMN's don't respond to chemotactic stimuli
Eczema, cold abscesses, coarse facial features, 2 rows of teeth
Job's syndrome
Abnormal integrins so phagocytes can't exit circulation
Delayed separation of umbilicus
Leukocyte adhesion deficiency