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62 Cards in this Set
- Front
- Back
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Upper limb & lateral breast drain to what LN?
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Axillary
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Stomach drains to what LN?
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Celiac
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Duodenum & jejunum drain to what LN?
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Superior Mesenteric
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Sigmoid colon drains to what LN?
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Colic --> Inferior Mesenteric
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Rectum (lower part), anal canal above pectinate line drain to what LN?
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Internal iliac
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Anal canal below pectinate line drains to what LN?
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Superficial inguinal
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Testes drain to what LN?
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Superficial & deep plexuses --> para-aortic
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Scrotum drains to what LN?
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Superficial inguinal
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Thigh drains to what LN?
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Superficial inguinal
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Lateral side of dorsum of foot drains to what LN?
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Popliteal
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ANA
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SLE
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anti-dsDNA, anti-Smith
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Specific for SLE
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Antihistone abs
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Drug induced lupus
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Anti-IgG (rheumatoid factor)
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Rheumatoid arthritis
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Anticentromere
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Scleroderma (CREST)
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Anti-Scl-70 (anti-DNA topoisomerase I)
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Scleroderma (diffuse)
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Antimitochondrial
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primary biliary cirrhosis
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Antigliadin, antiendomysial
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Celiac disease
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Anti-basement membrane
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Goodpasture's Syndrome
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Anti-desmoglein (desmosomes)
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Pemphigus Vulgaris
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Antimicrosomal, antithyroglobulin
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Hashimoto's thyroiditis
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Anti-Jo-1
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Polymyositis, Dermatomyositis
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anti-SSA (anti-Ro) & Anti-SS-B (anti-La)
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Sjorgen's syndrome
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Anti-U1 RNP (ribonucleoprotein)
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Mixed CT disease
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Anti-smooth muscle
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Autoimmune hepatitis
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Anti-glutamate decarboxylase
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Type I DM
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c-ANCA
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Wegener's granulomatosis
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p-ANCA
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microscopic polyangiitis, churg strauss
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MPO-ANCA
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Pauci immune crescentic GN
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anti-TSH
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Graves disease
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anti-Ach
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Myasthenia Gravis
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This cytokine is secreted by macs. Causes acute inflammation. Induces chemokine production to recruit leukocytes; activates endothelium to expression adhesion molecules. An endogenous pyrogen.
OT |
IL-1
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Secreted by Th1 cells. Stimulates growth of helper & cytotoxic T cells
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IL-2
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Secereted by activated T cells. Supports the growth & differentiation of BONE MARROW stem cells. Functions similar to GM-CSF
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IL-3
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Secreted by Th2 cells. Promotes growth of B cells. Enhances class switching IgE & IgG.
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IL-4
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Secreted by Th2 cells. Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates production and activation of EOSINOPHILS
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IL-5
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Secreted by Th cells & macs. Stimulates production of acute phase reactants & immunoglobulins
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IL-6
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Secreted by macs. Major chemotactic factor for neutrophils (as well as C5a
& LTNB4) |
IL-8
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Secreted by regulatory T cells. Inhibit actions of activated T cells. Activates Th1
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IL-10
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Secreted by B cells & macs. Activates NK & Th1 cells.
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IL-12
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Secreted by Th1 cells. Stimulates macs. Activates Th1, inhibits Th2
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IFN-gamma
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Secreted by macs. Mediates septic shock. Causes leaukocyte recruitment, vascular leak.
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TNF
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Cell surface receptors for Helper T cells
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CD4, TCR, CD3, CD28, CD40L
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Cell surface receptors for Cyotoxic T cells
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CD8, TCR, CD3
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B Cell cell surface receptors
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IgM, CD19, CD20, CD21, CD40, MHC II, B7
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Macrophages Cell surface receptors
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MHC II, B7, CD40, CD14, Receptors for Fc & C3b
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NK cell surface receptors
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Receptors for MHC I, CD16 (binds Fc of IgG), & C3b
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All cells except mature red cells
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MHC I
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CD55 & CD59 are located on
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WBC, RBC, & platelets -- protect these cells from complement mediated damage
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Diseases w/ increased ESR
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polymyalgia rheumatica
temporal arteritis disease activity RA & SLE infection, inflammation (osteomyelitis) malignancy |
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X-linked disease in boys
B cell deficiency --> defective TK gene --> low levels of all Ig's Recurrent bacterial infections after 6m |
Bruton's agammaglobulinemia
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3rd & 4th pouches fail to develop --> no thymus --> no T cells & no PTH --> low Ca --> tetany (chvosteks & trousseau's)
Recurrent viral, fungal, protozoal infections Congenital defects in heart/great vessels 90% chr 22q11 deletion |
Thymic aplasia (DiGeorge)
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Defect in early stem cell differentiation
ADA deficiency Last defense is cytotoxic NK cells Triad: severe recurrent infections, chronic diarrhea, FTT No thymic shadow on newborn CXR |
SCID
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T cell dyxfxn v C. albicans
Rx: ketoconazole |
Chronic Mucocutaneous Candidiasis
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X-Linked immunodeficiencies
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WBC:
Wiskott Aldrich Bruton's agammaglobulinemia Chronic granulomatous disease Hyper-IgM syndromes |
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Immunodeficiency
Thrombocytopenia & purpura Recurrent pyogenic infections low IgM & high IgA X Linked |
Wiskott -Aldrich
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IgA deficiency
Cerebellar ataxia & poor smooth pursuit of moving target w/ eyes Telangiectasia of face >5 yo Inc cancer riskL lymphoma & acute leukemias Radiation sensitivity +/- inc afp in kids >8 m |
Ataxia telangiectasia
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IgA deficiency
Recurrent sinus & lung infections A/w atopy & asthma |
Selevtive Ig Deficiency
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Lack NADPH oxidase (impotent phagocytes)
Susceptible to CATALASE (+) organisms Dx w/ nitroblue tetrazolium (NBT) dye --> no yellow to blue black oxidation |
Chronic Granulomatous Disease
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Defective LYST gene
Defective phagocyte lysosome Dx: Giant cytoplasmic granules in PMNs Triad: partial albinism, recurrent RTI & skin infections, neuro d/o |
Chediak Higashi Disease
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Hyper IgE
Deficient IFN gamma -- PMN's don't respond to chemotactic stimuli Eczema, cold abscesses, coarse facial features, 2 rows of teeth |
Job's syndrome
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Abnormal integrins so phagocytes can't exit circulation
Delayed separation of umbilicus |
Leukocyte adhesion deficiency
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