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81 Cards in this Set

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CD surface marker displayed only by helper T cells
CD4
CD surface marker displayed only by cytotoxic T cells (& suppressor T cells)
CD8
CD surface marker found on all T cells (except NK cells)
CD3 (& CD2)
CD surface marker used to ID B cells
CD19, 20, 21 (IgM & IgD)
CD surface marker found on all NK cells & binds the constant region of IgG
CD16
(also on macrophages)
CD surface marker that inhibits complement C9 binding
CD55 & CD59
CD surface marker that's an endotoxin receptor found on macrophages
CD14
cytokines that promote B cell growth & differentiation
IL-4 & IL-5
cytokines that are produced by TH1 cells
IL-2 & IFN-gamma
cytokines that are produced by TH2 cells
IL-4, IL-5, IL-10
cytokines that are involved in growth & activation of eosionphils
IL-5
cytokines secreted by helper T cells & activates macrophages
IFN-gamma
cytokines that inhibit macrophage activation
IL-10
pyogens secreted by monocytes & macrophages
acute phase cytokines
→ IL-1, IL-6, IFN-gamma
acute phase cytokines
IL-1, IL-6, IFN-gamma
cytokines that inhibit production of TH1 cells
IL-10
cytokines that inhibit production of TH2 cells
IFN-gamma
cytokines that mediate inflammation
acute phase cytokines
→ IL-1, IL-6, IFN-gamma
cytokines that enhance synth of IgE & IgG
IL-4
cytokines that enhance synth of IgA
IL-5
cytokines released by virally infected cells
IFN-gamma & IFN-beta
cytokines that support growth & differentiation of bone marrow stem cells
IL-3
cytokines that support T cell proliferation, differentiation, & activation
IL-2
immunoglobulin a/w allergies b/c it's bound by mast cells & basophils & causes them to degranulate & release their histamine
IgE
immunoglobulin that comprises 70-75% of the total immunoglobulin pool
IgG
immunoglobulin that is present in large quantities on the membrane of many B cells
IgM & IgD
immunoglobulin that crosses the placenta & also confers immunity to neonates in the 1st few months of life
IgG
immunoglobulin that can occur as a dimer
IgA
immunoglobulin that is largely confined to the intravascular pool & is the predominant early antibody freq seen in the immune response to infectious organisms w/complex antigens
IgM
immunoglobulin that is distributed evenly btwn the intravascular & extravascular pools
IgG
the predominant immunoglobulin in mucoserous secretions such as saliva, colostrum, milk, tracheobronchial secretions, & genitourinary secretions
IgA
immunoglobulin that can be a pentamer
IgM
hypersensitivity rxn of poststrep glomerulonephritis
type III
hypersensitivity rxn of asthma
type I
hypersensitivity rxn of rheumatic fever
type II
hypersensitivity rxn of TB skin test
type IV
hypersensitivity rxn of allergies, anaphylaxis & hay fever
type I
hypersensitivity rxn of polyarteritis nodosa
type III
hypersensitivity rxn of serum sickness
type III
hypersensitivity rxn of ABO blood type incompatibility
type II
hypersensitivity rxn of poison ivy
type IV
hypersensitivity rxn of eczema
type I
hypersensitivity rxn of contact dermatitis
type IV
hypersensitivity rxn of goodpasture's syndrome
type II
(anti-GBM Ab's)
complement responsible for PMN chemotaxis
C5a
young child presents w/tetany from hypocalcemia & candidiasis from immunosuppression→ what cell type is deficient?
DiGeorge → no T cells
young child has recurrent lung infxs & granulomatous lesions → what is the defect in the PMN's?
NADPH oxidase deficiency (chronic granulomatous dz) & no O2 free radicals
2 y/o child who has had multiple viral & fungal infxs & is found to be hypocalcemic→ which type of germ cell (ecto/endo/meso) gives rise to the missing structure in this child?
DiGeorge→ ENDOdermal pouches
child has an immune d/o in which there is a repeated staph abscess→ it is found that the PMN's fail to respond to chemotactic stimuli→ what is the most likely dx?
Job's syndrome aka hyper-IgE
what would you expect to see w/Wiscott-Aldrich syndrome?
"WAITER"
- Immunodef
- Thrombocytopenia & purpura
- trunchal Eczema
- Recurrent pyogenic infxs
- XLR
- ↑IgA & ↓IgM
what is the cause of chronic granulomatous dz? what infxs are they susceptible to?
- NADPH oxidase deficiency
- phagocytes don't generate O2 free radicals
- susceptible to catalase (+) → S. aureus, S. epidermidis, Klebsiella, Candida
dz a/w antinuclear antibodies (ANA)
SLE & other rheum stuff
dz a/w anti-dsDNA & anti-Smith antibodies
specific for SLE
dz a/w antihistone antibodies
drug-induced lupus
dz a/w anti-IgG antibodies
rheumatoid arthritis
(IgM anti-IgG antibodies; rheumatoid factor)
dz a/w anticentromere antibodies
CREST scleroderma
dz a/w anti-scl-70 antibodies
diffuse scleroderma
(aka anti-DNA topoisomerase I antibodies)
dz a/w anti-DNA topoisomerase I antibodies
diffuse scleroderma
(aka anti-scl-70 antibodies)
dz a/w antimitochondrial antibodies
primary biliary cirrhosis
dz a/w antigliadin antibodies
celiac dz
(also antiendomysial antibodies)
dz a/w antiendomysial antibodies
celiac dz
(also antigliadin antibodies)
dz a/w anti-basement membrane antibodies
goodpasture's
dz a/w anti-desmoglein antibodies
pemphigus vulgaris
dz a/w antimicrosomal antibodies
Hashimoto's thyroiditis
(also antithyroglobulin antibodies)
dz a/w antithyroglobulin antibodies
Hashimoto's thyroiditis
(also antimicrosomal antibodies)
dz a/w anti-Jo-1 antibodies
polymyositis, dermatomyositis
dz a/w anti-SS-A (anti-Ro) antibodies
Sjogren's syndrome (& SLE)
dz a/w anti-SS-B (anti-La) antibodies
Sjogren's syndrome
dz a/w anti-UI RNP (ribonucleoprotein) antibodies
mixed CT disease
dz a/w anti-smooth muscle antibodies
autoimmune hepatitis
dz a/w anti-glutamate decarboxylase antibodies
type 1 DM
dz a/w c-ANCA
Wegener's granulomatosis
dz a/w p-ANCA
- microscopic polyangitis
- pauci immune cresecentric glomerulonephritis
- churg-strauss syndrome (anti-neutrophil cytoplasmic Ab)
dz a/w myeloperoxidase (MPO) ANCA
pauci-immune crescentric glomerulonephritis
dz a/w anti-TSH receptor antibody
grave's disease (hyperthyroidism)
dz a/w anti-ACh receptor antibody
myasthenia gravis
what drugs are composed of antibodies against TNF?
1) etanercept
2) infliximab
3) adalimumab
(mab = monoclonal antibody)
type II hypersensitivity has antibodies against...?
self
type III hypersensitivity has antibodies against...?
antigen (complex deposition)
a patient suffers from recurrent Neisseria infxs→ what complement proteins are deficient?
any MAC protein→ C5-C9
after a bone marrow transplant, a pt suffers from dermatitis, enteritis & hepatitis→ what dz process is occuring?
GVHD