+Immuno Dit

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CD surface marker displayed only by helper T cells

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CD4

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CD surface marker displayed only by cytotoxic T cells (& suppressor T cells)

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CD8

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CD surface marker found on all T cells (except NK cells)

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CD3 (& CD2)

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CD surface marker used to ID B cells

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CD19, 20, 21 (IgM & IgD)

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CD surface marker found on all NK cells & binds the constant region of IgG

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CD16
(also on macrophages)

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CD surface marker that inhibits complement C9 binding

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CD55 & CD59

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CD surface marker that's an endotoxin receptor found on macrophages

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CD14

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cytokines that promote B cell growth & differentiation

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IL-4 & IL-5

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cytokines that are produced by TH1 cells

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IL-2 & IFN-gamma

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cytokines that are produced by TH2 cells

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IL-4, IL-5, IL-10

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cytokines that are involved in growth & activation of eosionphils

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IL-5

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cytokines secreted by helper T cells & activates macrophages

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IFN-gamma

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cytokines that inhibit macrophage activation

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IL-10

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pyogens secreted by monocytes & macrophages

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acute phase cytokines
→ IL-1, IL-6, IFN-gamma

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acute phase cytokines

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IL-1, IL-6, IFN-gamma

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cytokines that inhibit production of TH1 cells

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IL-10

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cytokines that inhibit production of TH2 cells

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IFN-gamma

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cytokines that mediate inflammation

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acute phase cytokines
→ IL-1, IL-6, IFN-gamma

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cytokines that enhance synth of IgE & IgG

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IL-4

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cytokines that enhance synth of IgA

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IL-5

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cytokines released by virally infected cells

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IFN-gamma & IFN-beta

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cytokines that support growth & differentiation of bone marrow stem cells

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IL-3

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cytokines that support T cell proliferation, differentiation, & activation

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IL-2

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immunoglobulin a/w allergies b/c it's bound by mast cells & basophils & causes them to degranulate & release their histamine

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IgE

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immunoglobulin that comprises 70-75% of the total immunoglobulin pool

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IgG

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immunoglobulin that is present in large quantities on the membrane of many B cells

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IgM & IgD

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immunoglobulin that crosses the placenta & also confers immunity to neonates in the 1st few months of life

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IgG

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immunoglobulin that can occur as a dimer

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IgA

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immunoglobulin that is largely confined to the intravascular pool & is the predominant early antibody freq seen in the immune response to infectious organisms w/complex antigens

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IgM

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immunoglobulin that is distributed evenly btwn the intravascular & extravascular pools

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IgG

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the predominant immunoglobulin in mucoserous secretions such as saliva, colostrum, milk, tracheobronchial secretions, & genitourinary secretions

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IgA

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immunoglobulin that can be a pentamer

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IgM

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hypersensitivity rxn of poststrep glomerulonephritis

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type III

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hypersensitivity rxn of asthma

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type I

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hypersensitivity rxn of rheumatic fever

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type II

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hypersensitivity rxn of TB skin test

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type IV

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hypersensitivity rxn of allergies, anaphylaxis & hay fever

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type I

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hypersensitivity rxn of polyarteritis nodosa

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type III

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hypersensitivity rxn of serum sickness

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type III

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hypersensitivity rxn of ABO blood type incompatibility

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type II

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hypersensitivity rxn of poison ivy

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type IV

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hypersensitivity rxn of eczema

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type I

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hypersensitivity rxn of contact dermatitis

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type IV

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hypersensitivity rxn of goodpasture's syndrome

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type II
(anti-GBM Ab's)

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complement responsible for PMN chemotaxis

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C5a

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young child presents w/tetany from hypocalcemia & candidiasis from immunosuppression→ what cell type is deficient?

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DiGeorge → no T cells

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young child has recurrent lung infxs & granulomatous lesions → what is the defect in the PMN's?

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NADPH oxidase deficiency (chronic granulomatous dz) & no O2 free radicals

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2 y/o child who has had multiple viral & fungal infxs & is found to be hypocalcemic→ which type of germ cell (ecto/endo/meso) gives rise to the missing structure in this child?

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DiGeorge→ ENDOdermal pouches

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child has an immune d/o in which there is a repeated staph abscess→ it is found that the PMN's fail to respond to chemotactic stimuli→ what is the most likely dx?

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Job's syndrome aka hyper-IgE

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what would you expect to see w/Wiscott-Aldrich syndrome?

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"WAITER"
- Immunodef
- Thrombocytopenia & purpura
- trunchal Eczema
- Recurrent pyogenic infxs
- XLR
- ↑IgA & ↓IgM

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what is the cause of chronic granulomatous dz? what infxs are they susceptible to?

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- NADPH oxidase deficiency
- phagocytes don't generate O2 free radicals
- susceptible to catalase (+) → S. aureus, S. epidermidis, Klebsiella, Candida

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dz a/w antinuclear antibodies (ANA)

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SLE & other rheum stuff

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dz a/w anti-dsDNA & anti-Smith antibodies

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specific for SLE

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dz a/w antihistone antibodies

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drug-induced lupus

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dz a/w anti-IgG antibodies

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rheumatoid arthritis
(IgM anti-IgG antibodies; rheumatoid factor)

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dz a/w anticentromere antibodies

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CREST scleroderma

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dz a/w anti-scl-70 antibodies

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diffuse scleroderma
(aka anti-DNA topoisomerase I antibodies)

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dz a/w anti-DNA topoisomerase I antibodies

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diffuse scleroderma
(aka anti-scl-70 antibodies)

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dz a/w antimitochondrial antibodies

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primary biliary cirrhosis

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dz a/w antigliadin antibodies

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celiac dz
(also antiendomysial antibodies)

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dz a/w antiendomysial antibodies

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celiac dz
(also antigliadin antibodies)

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dz a/w anti-basement membrane antibodies

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goodpasture's

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dz a/w anti-desmoglein antibodies

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pemphigus vulgaris

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dz a/w antimicrosomal antibodies

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Hashimoto's thyroiditis
(also antithyroglobulin antibodies)

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dz a/w antithyroglobulin antibodies

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Hashimoto's thyroiditis
(also antimicrosomal antibodies)

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dz a/w anti-Jo-1 antibodies

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polymyositis, dermatomyositis

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dz a/w anti-SS-A (anti-Ro) antibodies

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Sjogren's syndrome (& SLE)

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dz a/w anti-SS-B (anti-La) antibodies

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Sjogren's syndrome

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dz a/w anti-UI RNP (ribonucleoprotein) antibodies

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mixed CT disease

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dz a/w anti-smooth muscle antibodies

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autoimmune hepatitis

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dz a/w anti-glutamate decarboxylase antibodies

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type 1 DM

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dz a/w c-ANCA

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Wegener's granulomatosis

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dz a/w p-ANCA

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- microscopic polyangitis
- pauci immune cresecentric glomerulonephritis
- churg-strauss syndrome (anti-neutrophil cytoplasmic Ab)

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dz a/w myeloperoxidase (MPO) ANCA

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pauci-immune crescentric glomerulonephritis

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dz a/w anti-TSH receptor antibody

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grave's disease (hyperthyroidism)

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dz a/w anti-ACh receptor antibody

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myasthenia gravis

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what drugs are composed of antibodies against TNF?

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1) etanercept
2) infliximab
3) adalimumab
(mab = monoclonal antibody)

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type II hypersensitivity has antibodies against...?

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self

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type III hypersensitivity has antibodies against...?

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antigen (complex deposition)

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a patient suffers from recurrent Neisseria infxs→ what complement proteins are deficient?

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any MAC protein→ C5-C9

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after a bone marrow transplant, a pt suffers from dermatitis, enteritis & hepatitis→ what dz process is occuring?

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GVHD