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123 Cards in this Set
- Front
- Back
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MHC I gene products
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HLA-A, HLA-B, HLA-C. Expressed on all nucleated cells of the body
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MHC II gene products
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HLA-DP, HLA-DQ, HLA-DR. Expressed on antigen-presenting cells
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CD4 molecules
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On the surface of T lymphocytes that interact with MHC-II, and will become helper T cells
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CD8 molecules
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On the surface of T lymphocytes that interact with MHC-I, and will become cytotoxic T cells
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Cell markers: μ+
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pre-B cells in bone marrow with heavy chains
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Cell markers: Tdt+
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Progenitor B cells in bone marrow without heavy chains or pre-thymic/thymic cortex T cells
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B cell markers
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CD19, CD20, IgM, B7, CD40, CD20, MHC-II
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T cell markers
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CD4, CD8, CD3, TCR
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MHC-I and MHC-II coreceptors on T cells
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MHC-I --> CD8; MHC-II --> CD4
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LFA-1
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On T cells binds ICAM-1 on macrophages to increase cell-cell adherence during antigen presentation
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CD2
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On T cells binds LFA-3 on macrophages to increase cell-cell adherence
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CD28
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On T cells binds B7 on macrophages to trigger transcription of cytokines
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Cytokines produced by TH1 cells
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IFN-γ, TNF-β, IL-2
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Cytokines produced by TH2 cells
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IL-2, IL-4, IL-5, IL-6, IL-10
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Cytokines that stimulate TH1 differentiation
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IL-12, IFN-γ produced by macrophages
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Cytokines that stimulate TH2 differentiation
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IL-4 self-produced by TH2 cells
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Cytokines that inhibit TH1 cells
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IL-4 and IL-10 produced by TH2 cells
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Cytokines that inhibit TH2 cells
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IFN-γ
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Cytokines that stimulate B cell differentiation
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IL-4 and IL-5 produced by TH2 cells
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B7
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On antigen presenting cells such as macrophages and B lymphocytes. It binds CD28 on T lymphocytes to activate production of cytokines
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CD40L
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On TH2 cells. Binds CD40 on B lymphocyte to induce proliferation and isotype swtching. Deficient in X-linked hyper IgM syndrome.
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Costimulatory molecules on B cells
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CD40 and B7, bind CD40L and CD28 on TH2 cells
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Costimulatory molecules on T cells
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LFA-1, CD2, CD28. Bind ICAM-1, LFA-3 and B7 on macrophages respectively
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IFN-γ
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Secreted by TH1, CD8 and NK cells. Stimulates TH1 proliferation, inhibits TH2 proliferation, enhances macrophage phagocytosis, upregulate MHC molecules.
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CTL costimulatory molecules
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CD28 on CTLs bind B7 on APCs. IL-2 produced by TH1 cells stimulate CTL differentiation
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NK cell markers
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CD16 and CD56
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Macrophage cell markers
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CD14
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CD2 (LFA-2)
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Adhesion molecule expressed by T-cells, thymocytes, NK cells. Binds LFA-3 on lymphocytes and APCs
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CD3
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Signal transduction complex of T cells
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CD4
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Co-receptor for TCR-MHC-II interaction on TH cells. Receptor for HIV.
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CD8 molecules
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Co-receptor for MHC-I/TCR interaction to CTLs.
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CD14
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LPS receptor binds LPS expressed by monocytes, macrophages, granulocytes
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CD16
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Fc receptor on NK cells, macrophages, neutrophils. IgG-mediated opsonization and ADCC
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CD18
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β chain of LFA-1 integrin on leukocytes. Cell adhesion molecule missing in LAD
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CD19
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Coreceptor with CD21 for B-cell activation and signal transuction
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CD20
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B-cell activation
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CD21
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Receptor for C3d and B cell coreceptor complex eith CD19. EBV receptor.
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CD28
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T cell receptor for costimulatory molecule B7 on APCs
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CD34
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Mediates adhesion to leukocyte L-selectin. Expressed by hematopoietic precurssors and HEVs
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CD40
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Expressed by APCs and endothelium. Binds CD40L on TH cells for activation
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CD10
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CALLA. Expressed by acute lymphlobastic leukemia cells (ALL)
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CD46
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Expressed by NK cells
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IL-1
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Secreted by APCs and endothelium. TH cell activation; B-cell maturation; Enhances NK cells; Increases ICAM expression on endothelium; Chemotactic for macrophages and neutrophils; Acute phase reactant synthesis by hepatocytes; Induces fever in hypothalamus
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IL-2
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Secreted by TH cells. Induces proliferation and enhances activity of TH and CTLs
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IL-3
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Secreted by TH and NK cells. Growth and differentiation of myeloid cells
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IL-4
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Secreted by TH2 cells. Costimulates activation of antigen-primed B cells; Stimulates proliferation and differentiation of activated B cells; Isotype switching from IgG1 to IgE; Suppresses TH1 cells; Stimulates TH2 cells.
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IL-5
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Secreted by TH2 cells. Stimulates proliferation and differentiation of activated B cells and induces isotype switch to IgA
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IL-6
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Secreted by macrophages and TH2 cells. Promotes terminal differentiation into plasma cells; Stimulates Ab secretion; Promotes differentiation of myeloid stem cells; Induces acute-phase reactant synthesis by hepatocytes.
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IL-7
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Secreted by bone marrow and thymic stromal cells. Induces differentiation of lymphoid stem cells into progenitor B and T cells.
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IL-8
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Secreted by macrophages and endothelium. Chemotactic for neutrophils.
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IL-10
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Secreted by TH2 cells. Suppresses TH1 cells; Stimulates TH2 cells.
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IL-12
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Secreted by macrophages and B-cells. Differentiation of TH1 cells; Differentiation and proliferation of CD8 cells; Proliferation of NK and TH1 cells
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IFN-α
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Secreted by leukocytes. Inhibits viral replication
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IFN-β
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Secreted by fibroblasts. Inhibits viral replication
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TFG-β
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Secreted by platelets, macrophages, lymphocytes, mast cells. Induces IgA isotype switching on B cells
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TNF-α
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Secreted by macrophages and NK cells. Cytotoxic to tumor cells; Cytokine secretion by inflammatory cells; cachexia of chronic inflammation
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TNF-β
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Secreted by TH1 and CTLs. Cytotoxic to tumor cells; Enhances phagocytosis by macrophages and neutrophils
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Granulocyte colony-stimulating factor (G-CSF)
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Secreted by macrophages and TH cells. Proliferation of bone marrow granulocyte precursors; Used as Rx.: for neutropenia.
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Granulocyte macrophage colony stimulating factor (GM-CSF)
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Secreted by macrophages and TH cells. Proliferation of granulocyte and macrophage precursors. Used as Rx. For neutropenia.
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P-selectin
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Selectin on endothelium and platelets.
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E-selectin
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Selectin on activated endothelium
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L-selectin
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Selectin on leukocytes binds CD34 (endothelial venules), GlyCam-1 (HEVs) and MadCAM-1 (mucosal lymhpoid tissue venules)
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LFA-1
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Integrin expressed by monocytes, T cells, macrophages, neutrophils, dendritic cells. Binds ICAMs
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CR3
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On neutrophils and macrophages. Binds ICAM-1, iC3b, fibrinogen
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CR4
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On dendritic cells, macrophages, neutrophils. Binds iC3b
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VCAM-1
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Adhesion molecule xpressed by active endothelium. Binds VLA-4 on leukocytes
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ICAMs
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On vessels and lymphocytes. Bind LFA-1 on leukocytes.
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TH cell surface molecules
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CD4, CD3, TCR, CD28, CD40L
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CTL cell surface molecules
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CD8, TCR, CD3
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Macrophage cell surface molecules
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MHC-II, B7, CD40, CD14, Fc and C3b receptors
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NK cell surface molecules
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Receptors for MHC-I, CD16, CD56
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Type of hypersensitivity: Anaphylaxis
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Type I
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Type of hypersensitivity: Allergic rhinitis
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Type I
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Type of hypersensitivity: hemolytic anemia
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Type II
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Type of hypersensitivity: ITP
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Type II
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Type of hypersensitivity: eythroblastosis fetalis
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Type II
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Type of hypersensitivity: rheumatic fever
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Type II
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Type of hypersensitivity: Goodpasture syndrome
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Type II
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Type of hypersensitivity: Bullous pemphigoid
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Type II
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Type of hypersensitivity: Graves
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Type II
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Type of hypersensitivity: Myasthenia gravis
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Type II
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Type of hypersensitivity: SLE
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Type III
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Type of hypersensitivity: Rheumathoid arthritis
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Type III
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Type of hypersensitivity: PAN
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Type III
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Type of hypersensitivity: Poststrep glomerulonephritis
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Type III
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Type of hypersensitivity: Serum sickness
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Type III
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Type of hypersensitivity: Arthus reaction
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Type III
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Type of hypersensitivity: Hypersensitivity pneumonitis
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Type III
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Type of hypersensitivity: Type 1 DM
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Type IV
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Type of hypersensitivity: Multiple sclerosis
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Type IV
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Type of hypersensitivity: Guillain-Barre
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Type IV
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Type of hypersensitivity: Hashimoto's
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Type IV
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Type of hypersensitivity: Graft Vs. Host
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Type IV
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Type of hypersensitivity: PPD test for tuberculosis
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Type IV
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Type of hypersensitivity: Contact dermititis
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Type IV
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ANA
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SLE
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Anti-dsDNA
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Specific for SLE
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Anti-Smith
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Specific for SLE
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Antihistone
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Drug-induced lupus
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Anti-IgG
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Rheumathoid factor/rheumathoid arthritis
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Anticentromere
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CREST
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Anti-Scl-70
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Diffuse scleroderma
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Antimitochondrial
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Primary billiary cirrhosis
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Antigliadin
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Celiac disease
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Anti-GBM
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Goosdpasture
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Anti-epithelial cell
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Pemphigus vulgaris
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Antimicrosomal
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Hashimoto's
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Antithyroglubulin
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Hashimoto's
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Anti-Jo-1
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Polymyositis, dermatomyositis
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Anti-SS-A (anti-Ro)
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Sjogren
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Anti-SS-B (anti-La)
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Sjogren
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Anti-U1 RNP
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Mixed connective tissue disease
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Anti-smooth muscle
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Autoimmune hepatitis
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Anti-glutamate decarboxylase
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Type 1 DM
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c-ANCA
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Wegener's
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p-ANCA
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PAN
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HLA-B27
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Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, Reiter's (PAIR)
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HLA-B8
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Grave's disease, celiac sprue
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HLA-DR2
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Multiple sclerosis, hay fever, SLE, Goodpasture
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HLA-DR3
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DM type 1
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HLA-DR4
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Rheumathoid arthritis, type 1 DM
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HLA-DR5
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Pernicius anemia, Hashimoto's
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HLA-DR7
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Steroid-responsive nephrotic syndrome
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