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30 Cards in this Set

  • Front
  • Back
TLR 4
LPS recognition
TLR2
Peptidoglycan recognition
TLR3
Endosomal; DS viral RNA recognition
TLR7
Endosomal; SS viral RNA recognition
TLR8
Endosomal; SS viral RNA recognition
Neutrophils

granules

surface
Extravasate to infection site; sign of infection

Surface:

Secretes: IL-12

Specific granules: collegenase, elastase (for rebuilding) lysozyme (these are specific for PMN)

Azurophilic granules: digestive, cathelcidin and defensins (natural microbials) (non-specific for PMN)

MQ secrete chemokines to direct entrance

surface: integrin receptor, selector ligand
Dendritic Cell
Activated by
secretes
activates
function
surface
Activated by: IL-2, IFN-g, CD40:40L

Secretes: IL-12 aids in activation of TH1 (not TH2) and CTLs, TNF

Activates: T cells
TH (MHC, costim, cytokines)not TH2
CTL (direct, indirect, cross-pres)

Function: Only one that can stim Naive T!
Controlled Cross-present

Surface: CCR7 (to bring to nodes);costim CD80/86, CD40, antigen receptors (TLRs!), CD25(IL-2r), ICAM-1, MHC(constit)
MQ
activated by
secretes
surface
function
Activated by: IFN-g (from NK, TH1)

Secretions:
Activation: IL-12 (dif TH1); TNF
Suppression:IL-1and TGF-B (to alter endothelial for extravasation)

Surface: costim CD80/86, CD40, antigen receptors (TLRs), IFN-gR

Function:
Classical-Activation:Change endothelial for T and neutrophil, Phag, stim dif of TH1
Alternative-Suppression:Secrete IL-1, TNF, TGF-B, granuloma formation
IL-12
secreted by
activates
function
stimulated by
Secreted by: TH1 (autocrine), MQ, DC

Activates:
MQ
NK & TH1 (activates and to promotes IFN-g secretion);
CTL (enhance cytosolic activity)

Function:
MQ activation to increase phagocyt via T cell intermend
T cell activation (via MHC II)
CTL activation (via MHC I) and incr cytotoxicity

Stimulated by:
TLR
CD40:CD40L
IFN-g (from NK)
IL-2
Secreted by: activated T cell

Activates: TH1(autocrine), NK (stim IFN-g secretion), B cells

Clonal Expansion (proliferation)
Licensing
APC w/ no PAMPs in sight

Activated by T cell via CD40:CD40L (CD40 on APC)...

stim APC to express CD80/86...

so that APC can stim other T cells
TNF
secreted by
activates
function
Secreted by: monocytes

Activates: monocytes, endothelial cells

Function: monocyte recruitment
Extravasation:
chemokine
change epithelial adhesion mol
microbicidial
TGF-B
Secreted by
Responds
function
Secreted by: T regs, activated T, MQ

Responds: inhibits T, MQ and counteract inflammation (from self-reg and "alt MQ activ" via TH2)

IgA isotype switching
tissue repair
Il-15
Secreted by: MQ

Activates: NK (for viral infection)
IL-10
secreted by
inhibits
function
Secreted by: Tregs, activated T cells, MQ

Inhibits: MQ("alt MQ activation" by TH2)
T cell prolif; T cell effector


Function: suppressive in stemming T cell and MQ activation

Epstein-Barr is homologous
TH2
activated by
secretes
activates
surface
function
MQ activation
txt factors
Activated by: IL-2 (prolif) IL-4 (dif)

Secretes: IL-4 (autocrine & IgE switch), IL-5 (helminth)

Activates: TH2 dif, B cell isotype,

Surface: IL-4r, CD25,

Function: suppression via "alt MQ activ"
responds to eosinophil (allergies) and helminth infection, granuloma formation "barrier immunity"

MQ "Alt MQ activ" to secrete
suppressive IL10 and TGF-B

txt: GATA-3 (master), STAT6 to STAT6, GATA-3
TH1
activated by
secretes
activates
surface
function
MQ activation
txt factors
Activated by: IL-2(prolif) IL-4 (dif)

Secretes: IFN-g (autocrine & MQ activation)

Activates: TH1 dif, MQ activation!!, complements

Surface: CD25, IL-12r, IFN-gR, E/P selectin, integrin(r), CXCR5 and CCR5 (extrav), CD40L, CD28

Function:MQ activ (phag for inflamm), complement fixing, opsonizaation

MQ activ "Classical Path"

Txt factor: Tbet (control), STAT1

DTH Rxn (memory), can form granuloma (MQ cytokines, not TH1)
IL-5
activates eosinophils
(ie. in helminth infection)

secreted by: TH2, activated mast

JAK/STAT pathway
IL-4
involved in TH2 diff
prompts IgE switching in B cells

secreted by: TH2, activated mast

JAK/STAT pathway
IFN-g
secreted by
affects
function
Secreted by: TH1, CD8+, NK

Affects: T into TH1, MQ, B cells, APCs

Function:
MQ activation- phag
TH1 dif
IgG isotype switching
MHC I + II expression

To increase inflamm rxns
inhibit TH2 path
CRP
C Reactive Protein
Opsinization: C1q binding and IgG FcR

Classical Pathway
MBL
Aid Phagocytosis: binds Ag and Mannose on microbe surface

Complement Activation

Lectin Pathway
Phagocytes recognize
PAMP Receptors

Opsins (Ab, complements, lectins)
Classical Pathway
components
binding
C1q, has FcR
Cs2r2
starts w/ C4, C2

Binds Ab to Ag
Lectin Pathway
components
binding
MLB
MASP1, MASP2
starts w/ C4, C2

binds mannose on microbe surface
Alternative Pathway
No C1q or MLB
C3b bind first

Factor B --> c3 convertase
C1 INH
inhibits C1s2r2 binding
C59
stops formation of MAC
IL-7
stimulates HSC into lymphoid line
Hassal's corpsucle
death of TEC; only in thymus

role iin Treg development