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50 Cards in this Set
- Front
- Back
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intracellular location of phagococytized microbes
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vesicles (phagolysosome)
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location of most intracellular pathogens that have invaded cells
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cytoplasm
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T cell accessory molecule that binds co-stimulators
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CD28
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T cell accessory molecule involved in negative regulation of activated T cells
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CTLA-4
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APC molecule that provides second signal to T cells
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B7
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T cell accessory molecules involved in signal transductions
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CD4, CD8, CD3, and zeta
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T cell accessory molecules involved in adhesion
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LFA-1 and VLA-4
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Substances that induce expression of co-stimulators on APCs
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adjuvants
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Autocrine cytokine that promotes T cell proliferatoin
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IL-2
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region of contact between APC and T cell
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immunologic synapse
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anatomical site of activation of T cells by APCs
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paracortex of lymph nodes
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tyrosine motifs on CD3 and zeta chains involved in signaling
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ITAMs
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tyrosine kinase that triggers several signaling pathways
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ZAP-70
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high affinity version of the IL-2 receptor
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IL-2Rαβγc
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T cell population that defends against intracellular microbes
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Th1
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cytokines that drive development of Th1 clls
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IL-2, interferon gamma
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signature cytokines of Th1 cells
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interferon-gamma, TNF, IL-2
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T cell population that defends against extracellular microbes
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Th2
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Cytokine that drives development of Th2 cells
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IL-4
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Signature cytokines of Th2 cells
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IL4, IL5, IL-12
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T cell population involved in inflammatory disorders
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Th17
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signature cytokines of Th17
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IL-17, Il-22
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Cytokine that inhibits T cell activation
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TGFBeta
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Cytokine that induces B cell switching to produce IgE
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IL-4
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Cytokine that activates eosinophil
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IL-5
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T cell population that drives activation of macrophages and production of some classes of antibodies
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Th1
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T cell population that drives production of some classes of antibodies
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Th2
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T cell population that directly kills infected cells
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CTLs
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Ligand expressed on CD4+ T cells that makes APC better at stimulating T cells
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CD40L
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Defense against ingested microbes
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Th1 Cells
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Defense against infected cells with microbes in cytoplasm
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CTLs
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Anatomical site of activation of naive T cells
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lymphoid organs
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anatomical site of antigen elimination by effector T cells
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peripheral tissues
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homing molecules on activated T cells
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E and P selectin ligand, LFA-1 or VLA-4, CXCR3
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homing molecules on naive T cells
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L-selectin, LFA-1, CCR7
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immune-mediated tissue damage
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hypersensitivity
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effector cell of delayed-type hypersensitivity (DTH)
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macrophage
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major cytokine that activates macrophages to kill ingested microbes
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IFNgamma
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skin test that detects DTH response to mycobacteria
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PPD
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time frame to elicit a DTH reaction
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24-48 hours
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mechanisms of damage in DTH
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macrophages, CTLs, granulomatous inflammation
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chronic CMI response to TB
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granulomas
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defense against helminth infections
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IgE and IL-5-activated eosinophils
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enzymes that cleave and activate caspases
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granzymes
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protein necessary for delivery of granzymes into target cells
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perforin
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mechanism of CTL-mediated killing of target cell
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apoptosis
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cytokines that inhibit microbicidal activity of macrophages
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IL-4, IL-10, IL-13
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activating signals for CTLs
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antigen recognition and firm adhesion
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viral-induced mechanism of immune evasion
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inhibit antigen presentation
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mycobacteria-induced mechanism of immune evasion
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inhibit phagolysosome function
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