Immuno Ch 3 And 4

Front 1

Processed peptides bound to MHC molecules

Back 1

T cell antigens

Front 2

recognition by T cells of peptides bound to one's own MHC

Back 2

MHC restriction

Front 3

cells that capture and present peptides to T cells

Back 3

APC

Front 4

dendritic cells, macrophages, B cells

Back 4

professional APC

Front 5

another name for immature dendritic cell in the skin

Back 5

langerhans cells

Front 6

transports antigen from epithelia to draining lymph node

Back 6

dendritic cell

Front 7

destination of antigens captured in epithelia and sub-epithelial tissues

Back 7

lymph nodes, MALT, GALT, BALT

Front 8

destination of blood borne antigens

Back 8

spleen

Front 9

microbial-indcuced activators of dendritic cells

Back 9

TNF, IL-1, TLR signaling

Front 10

destination of dendritic cells in lymph nodes

Back 10

T cell zones

Front 11

chemical signal that attracts activated dendritic cells to draining lymph node

Back 11

chemokines that bind to CCR7 on dendritic cell

Front 12

afferent lymphatic vessel -lymph node - efferent lymphatic vessel

Back 12

flow of lymph through a draining lymph node

Front 13

human major histocompatibility complex (MHC) proteins

Back 13

human leukocyte antigens (HLA)

Front 14

genes that encode the Class I MHC moleucules

Back 14

HLA -A.B,C

Front 15

cells that express class I MHC molecules

Back 15

all nucleated cells

Front 16

genes that encode the class II MHC molecules

Back 16

HLA-DP,DQ,DR

Front 17

cells that express class II MHC molecules

Back 17

professional APCs

Front 18

set of MHC alleles present on each chromosome

Back 18

MHC haplotype

Front 19

MHC molecules that are recognized by CD8+ T cells

Back 19

Class I

Front 20

MHC molecules that are recognized by CD4+ T cells

Back 20

Class II

Front 21

domains of peptide-binding groove of MHC class I molecules

Back 21

alpha1; alpha2

Front 22

CD8 binding site of MHC Class I molecule

Back 22

alpha3

Front 23

domains of peptide-binding groove of MHC Class II molecules

Back 23

alpha1, beta1

Front 24

CD4 binding site of MHC Class II molecule

Back 24

Beta2

Front 25

source of antigens for MHC Class I molecules

Back 25

endogenous cytosolic proteins

Front 26

source of antigens for MHC Class II molecules

Back 26

endosome/lysosomes

Front 27

site of peptide loading for MHC class I molecule

Back 27

endoplasmic reticulum

Front 28

site of peptide loading for MHC class II molecule

Back 28

vesicle

Front 29

enzymes that generate peptides for MHC class I molecules

Back 29

proteasome

Front 30

enzymes that generate peptides for MHC Class II molecules

Back 30

proteases in vesicles

Front 31

T cell population that responds to peptide: MHC Class II molecules

Back 31

CD4+ T cells

Front 32

T cell population that responds to peptide: MHC CLass I molecule

Back 32

CD8+ T cells

Front 33

two heavy chains and two light chains

Back 33

Ig or B cell receptor

Front 34

antigen-binding domains of a B cell receptor

Back 34

VH or VL

Front 35

predominant version of T cell receptor in adaptive immunity

Back 35

alphabeta receptor

Front 36

antigen-binding domains of the TCR

Back 36

Valpha, Vbeta

Front 37

signaling molecules of the BCR complex

Back 37

Igalpha and Igbeta

Front 38

signaling molecules of TCR complex

Back 38

CD3 and weird shape

Front 39

complexes of peptide: MHC molecules

Back 39

T cell antigen

Front 40

proteins, polysaccharides, lipids, nucleic acids, small chemicals

Back 40

B cell antigens

Front 41

cells whose antigen receptors that are both membrane bound and secreted

Back 41

BCR/Immunoglobulin

Front 42

portion of Ig molecule that binds antigen

Back 42

Fab

Front 43

portion of Ig molecule that binds comlement

Back 43

Fc

Front 44

portion of Ig molecule that binds to macrophages

Back 44

Fc

Front 45

number of antigen binding sites on the TCR

Back 45

one

Front 46

most abundant antibody in the blood stream

Back 46

IgG

Front 47

IgG heavy chain

Back 47

gamma

Front 48

antibody found in GI tract, colostrum, sweat, tears, saliva

Back 48

dimeric IgA

Front 49

IgA heavy chain

Back 49

alpha

Front 50

pentameric antibodi that potentially activates complement

Back 50

IgM

Front 51

IgM heavy chain

Back 51

mu

Front 52

only antibody that crosses the placenta

Back 52

IgG

Front 53

major class of antibody directed at helminth infectoins

Back 53

IgE

Front 54

IgE heavy chain

Back 54

sigma

Front 55

classes of antibody that serve as BCR on naive B cells

Back 55

IgD and IgM

Front 56

IgD heavy chain

Back 56

delta

Front 57

antibody that activates mast cells

Back 57

IgE

Front 58

opsonizing antibodies

Back 58

IgG and IgA

Front 59

two classes of Ig that possess a J chain

Back 59

IgM and IgA

Front 60

half-life of IgG

Back 60

21 days

Front 61

derivation of antibodies from a single clone of B lymphocytes that have identical antigen specificity

Back 61

monoclonal antibody

Front 62

kappa and lambda

Back 62

Ig light chains

Front 63

portion of Ig molecule that determines isotope

Back 63

heavy chain

Front 64

activated and differentiated B cell that secretes antibody

Back 64

plasma cell

Front 65

gene segments in variable regions of Ig heavt chain and TCR beta chain

Back 65

V,D, and J

Front 66

first recombination event in BCR heavy chain and TCR beta chain

Back 66

D-J joining

Front 67

Ig light chain and TCR alpha chain gene segments in variable regions

Back 67

V and J

Front 68

rearrangement of V,D and J segments

Back 68

somatic recombination

Front 69

process that ensures expression of BCR with single specificity

Back 69

allelic exclusion

Front 70

change of Ig class but perservation of antigen specificity

Back 70

isotype switching

Front 71

nucleotide changes in variable region of Ig genes affecting affinity for antigen

Back 71

somatic hypermutation

Front 72

enzymes responsible for somatic recombination

Back 72

VDJ recombinase (RAG-1 and RAG-2)

Front 73

number of CDRs in an intact TCR

Back 73

six

Front 74

total number of V-D-J recombinations

Back 74

combinatorial diversity

Front 75

stage of B cell with no detectable recombination events

Back 75

pro-B cell

Front 76

number of CDRs in an intact BCR

Back 76

six

Front 77

stage of B cell with recombined H chain and mu RNA and surrogate light chains

Back 77

pre-B cell

Front 78

stage of B cell with IgM expressed on surface

Back 78

immature B cell

Front 79

stage of B cell with IgM and IgD expressed on surface

Back 79

mature B cell

Front 80

stage of T cell with no recombined beta chain

Back 80

double negative thymocyte, pro-T cell

Front 81

stage of T cell with recombined Beta chain and expressed pre-T alpha

Back 81

pre-T cell

Front 82

stage of T cell with expressed TCR and both CD4 and CD8

Back 82

double-positive T cell; immature T cell

Front 83

weak recognition of MHC class II + self peptide

Back 83

positive selection for CD4+

Front 84

weak recognition of MHC Class I + self peptide

Back 84

positive selection for CD8+

Front 85

no recognition of MHC + self-peptide

Back 85

failure of positive selection

Front 86

strong recognition of MHC + peptide

Back 86

negative selection