Immuno Ch 11

Front 1

During the Ag-independent phase, where are immature B cells expressing IgM generated?

Back 1

In the Bone Marrow

Front 2

Where does the Ag-dependent phase occur?

Back 2

in secondary lymph organs

Front 3

Where does the Ag-independent phase occur?

Back 3

in the bone Marrow

Front 4

What is the Life Span of a Naive B Cell?

Back 4

~4-8 weeks

Front 5

what % of potential B cells reach maturity & exit the bone marrow?

Back 5

~10%

Front 6

where do B-cells mature?

Back 6

in the bone marrow

Front 7

Where are B-cells activated and differentiated?

Back 7

in the Secondary lymph organs

Front 8

What surface marker does the progenitor B-cell express before Ig-gen rearrangement?

Back 8

CD45R (B220)

Front 9

what is required for maturation of Progenitor B cells into Precursor B cells?

Back 9

Bone-Marrow Stromal Cells

Front 10

What produces IL-7 during the transformation from a Pro-B to a Pre-B cell?

Back 10

Bone-Marrow Stromal Cells

Front 11

What rearrangements are required in the Pro-B cell stage to become a Pre-B cell?

Back 11

Heavy Chain D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h)

Front 12

Once a Pro-B cell undergoes D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h) what is it called?

Back 12

a Pre-B Cell

Front 13

what is required for a Pre-B cell to become an immature B cell?

Back 13

Productive Light-Chain gene rearrangement.

Front 14

What chain does a Pre-B cell express?

Back 14

a μ chain

Front 15

What does an immature B cell express?

Back 15

mIgM

Front 16

what determines the cells antigenic specificity?

Back 16

the heavy-chain VDJ sequence and light chain VJ sequence

Front 17

what two things do immature B cells express on the cell surface?

Back 17

mIgM & Ig-α/Ig-β

Front 18

during which stage of B-cell maturation is TdT active?

Back 18

during pro-B cell stage

Front 19

What rearrangements are required in the Pro-B cell stage to become a Pre-B cell?

Back 19

Heavy Chain D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h)

Front 20

what does the expression of mIgM & Ig-α/Ig-β form on the surface of an immature B cell?

Back 20

a B-cell receptor (BCR)

Front 21

Once a Pro-B cell undergoes D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h) what is it called?

Back 21

a Pre-B Cell

Front 22

what is required for a Pre-B cell to become an immature B cell?

Back 22

Productive Light-Chain gene rearrangement.

Front 23

what is the purpose of TdT during pro-B cell stage?

Back 23

to prevent V(L) & J(L) to have N-nucleotide addition

Front 24

What chain does a Pre-B cell express?

Back 24

a μ chain

Front 25

What does an immature B cell express?

Back 25

mIgM

Front 26

what determines the cells antigenic specificity?

Back 26

the heavy-chain VDJ sequence and light chain VJ sequence

Front 27

what two things do immature B cells express on the cell surface?

Back 27

mIgM & Ig-α/Ig-β

Front 28

during which stage of B-cell maturation is TdT active?

Back 28

during pro-B cell stage

Front 29

what does the expression of mIgM & Ig-α/Ig-β form on the surface of an immature B cell?

Back 29

a B-cell receptor (BCR)

Front 30

what is the purpose of TdT during pro-B cell stage?

Back 30

to prevent V(L) & J(L) to have N-nucleotide addition

Front 31

What rearrangements are required in the Pro-B cell stage to become a Pre-B cell?

Back 31

Heavy Chain D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h)

Front 32

Once a Pro-B cell undergoes D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h) what is it called?

Back 32

a Pre-B Cell

Front 33

what is required for a Pre-B cell to become an immature B cell?

Back 33

Productive Light-Chain gene rearrangement.

Front 34

What chain does a Pre-B cell express?

Back 34

a μ chain

Front 35

What does an immature B cell express?

Back 35

mIgM

Front 36

what determines the cells antigenic specificity?

Back 36

the heavy-chain VDJ sequence and light chain VJ sequence

Front 37

what two things do immature B cells express on the cell surface?

Back 37

mIgM & Ig-α/Ig-β

Front 38

during which stage of B-cell maturation is TdT active?

Back 38

during pro-B cell stage

Front 39

what does the expression of mIgM & Ig-α/Ig-β form on the surface of an immature B cell?

Back 39

a B-cell receptor (BCR)

Front 40

what is the purpose of TdT during pro-B cell stage?

Back 40

to prevent V(L) & J(L) to have N-nucleotide addition

Front 41

f

Back 41

a

Front 42

What rearrangements are required in the Pro-B cell stage to become a Pre-B cell?

Back 42

Heavy Chain D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h)

Front 43

Once a Pro-B cell undergoes D(h)&J(h) rearrangement, followed by V(h)-D(h)J(h) what is it called?

Back 43

a Pre-B Cell

Front 44

what is required for a Pre-B cell to become an immature B cell?

Back 44

Productive Light-Chain gene rearrangement.

Front 45

What chain does a Pre-B cell express?

Back 45

a μ chain

Front 46

What does an immature B cell express?

Back 46

mIgM

Front 47

what determines the cells antigenic specificity?

Back 47

the heavy-chain VDJ sequence and light chain VJ sequence

Front 48

what two things do immature B cells express on the cell surface?

Back 48

mIgM & Ig-α/Ig-β

Front 49

during which stage of B-cell maturation is TdT active?

Back 49

during pro-B cell stage

Front 50

what does the expression of mIgM & Ig-α/Ig-β form on the surface of an immature B cell?

Back 50

a B-cell receptor (BCR)

Front 51

what is the purpose of TdT during pro-B cell stage?

Back 51

to prevent V(L) & J(L) to have N-nucleotide addition

Front 52

what is the purpose of the RNA processing of the heavy chains?

Back 52

to produce to mRNAs, one encoding for μ chain and the other for the δ chain.

Front 53

What does a mature B cell express that an immature doesn't?

Back 53

mIgD

Front 54

In the formation of the immature-B cell receptor, what does the membrane μ chain associate with?

Back 54

The surrogate light chain

Front 55

to what is the 90% reduction in the population of B cells attributable to?

Back 55

Negative Selection

Front 56

Negative selection occurs when B cells with BCRs bind to________ are induced to_______?

Back 56

self-Ag

Apoptose

Front 57

what causes a self-reactive B cell to be 'rescued' from apoptosis?

Back 57

when editing/rearrangement occurs on their L chain genes that causes them to produce mIgM with different specificity

Front 58

which phase leads to the generation of plasma B-cells and memory B-cells

Back 58

the Ag-Dependent phase

Front 59

what do (TD) T-Dependent Ag require to activate the B cell?

Back 59

direct contact with T(H) cells

Front 60

what is an example of a type 1 (TI) Ag?

Back 60

LPS (Lipopolysaccharide)

Front 61

what is an example of a type 2 (TI) Ag?

Back 61

bacterial Flagellin

Front 62

which type of (TI) molecule are considered Mitogens?

Back 62

Type 1

Front 63

Which type of (TI) activate B cells non-specifically?

Back 63

Type 1

Front 64

Which type of (TI) can activate mature B cells but not immature B cells?

Back 64

Type 2

Front 65

Which type of (TI) can activate both mature and immature B cells?

Back 65

Type 1

Front 66

What is needed by type2 (TI) to get efficient B-Cell proliferation and class switching?

Back 66

T(H)-cytokines

Front 67

what type of signals are produced when a (TI-1) Ag binds to a B cell?

Back 67

both signals