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98 Cards in this Set
- Front
- Back
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Anti-acetylcholine receptor
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Myasthenia gravis
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Anti-basement membrane
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Goodpasture's Syndrome
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Anticentromere
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CREST Syndrome
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Antiendomysial IgA
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Celiac Disease
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Antigliadin IgA
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Celiac Disease
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Antihistone
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Drug induced lupus
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Anti-insulin
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Type 1 Diabetes
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Anti-islet cell
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Type 1 Diabetes
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Anti-instrinsic factor
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Pernicious anemia
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Anti-parietal cell
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Pernicious anemia
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Antimicrosomal
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Hasimoto's Thryoiditis
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Anti-Smith (Sm)
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SLE
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Anti-SS-A (Ro)
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Sjorgen's Syndrome(more specific) and SLE
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Anti-SS-B (La)
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Sjorgen's Syndrome
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Antithryoglobulin
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Hasimoto's Thryoiditis
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Anti-tissue transglutaminase IgA
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Celiac Disease
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Anti-topoisomerase
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Systemic sclerosis
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Antimitochondrial
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Primary biliary cirrhosis
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Antimyeloperoxidase
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Microscopic polyangitis
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Antinuclear antibodies (ANA)
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SLE (most speficic), Systemic sclerosis, Dermatomyositis
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Antiproteinase 3
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Wegener's granulomatosis
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Anti-ribonucleoprotein
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MCTD
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Anti-TSH receptor
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Grave's disease
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X-linked recessive, Mutated tyrosine kinase blocks B-cell differentiation, SP infections, dec. immunoglobulins
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Bruton's agammaglobulinemia
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Failure of IgA B cells to mature into plasma cells, Dec. IgA and secretory IgA, Anaphylasxis if exposed to blood products that contain IgA
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IgA Deficiency
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Defect in B-cell maturation to plasma cells, dec. immunoglobulins, SP infections, GI infections, pneumonia
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Common vairable immunodeficiency
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Failure of third and forth pharyngeal pouches to develop which leads to failure of thymus and parathyroid glands to develop, hypoparathyroidism
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DiGeorge Syndrome
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Autosomal dominant, Adenosine deaminase deficiency, adenine is toxic to B and T cells, dec. deoxyribonucleotides precursors for DNA synthesis
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Sever Combine Immunodefiency (SCID)
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X-linked recessive, Progressive deletion of B and T cells, dec. IgM, normal IgG, inc. IgA and IgE, Eczema, thrombocytopenia, SP infections (triad)
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Wiskott-Alrich syndrome
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Autosomal recessive disorder, Mutation in DNA repair enzymes, Thrymic hypoplasia, inc. AFP, dec. IgA, IgG, IgE, and T cell fxn
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Ataxia-Telangiectasia
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Autosomal dominant disorder with deficiency of C1 esterase inhibitor, normal C3, Swelling of face and oropharynx
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Hereditary angioedema
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Most common complement deficiency disorder, associated with septicemia and lupus like syndrome in children
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C2 deficiency
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Increase susceptibility to disseminated N. gonorrhoeae or N. meningitidis infections
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C6-C9 defiency
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Acquired stem cell disease, defect in molecule decay accelerating factor (DAF), complement mediated intravascular lysis of RBCs, platelets, and neutrophils
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Stimulates angiogenesis
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Vascular endothelial cell growth factors (VEGF), Basic fibroblast growth factor (BFGF)
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Stimulates keratinocyte migration and granulation tissure formation
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Epidermal growth factor (EGF)
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Stimulates proliferation of smooth muscle, fibroblasts, endothelial cells
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Platlet-derived growth factor (PDGF)
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Chemotactic for macrophages, lymphocytes, fibroblasts
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Transforming growth factor B (TGF-B)
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Stimulates syntehsis of collagen, promotes keratinocyte migration
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Insulin growth factor-1 (IGF-1)
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Chemotactic for neutrophils, Stimulates synthesis of metalloproteinases, Stimulates synthesis and release of acute phase reactants from the liver
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IL-1
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Key cell in acute inflammation, phagocytosis of opsonized bacteria (receptors for IgG and C3b)
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Neutrophil
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Key cells in chronic inflammation, receptors for IgG and C3b
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Monocytes and macrophages
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Draining site for Upper limb, lateral breast
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Axillary
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Draining site for Stomach
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Celiac
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Draining site for duodenum and jejunum
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Sup. Mesenteric
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Draining site for sigmoid colon
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Colic --> inf. Mesenteric
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Draining site for rectum (lower part), anal canal above pectinate line
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Interal iliac
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Draining site for anal canal above pectinate line
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Superficial inguinal
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Draining site for testes
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Superficial and deep plexuses --> para aortic
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Draining site for scrotum
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Superficial inguinal
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Draining site for superficial thigh
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Superficial inguinal
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Draining site for lateral side of dorsum of foot
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Popliteal
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HLA-A3
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Hemochromatosis
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HLA-B27
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Proriasis, Ankylosing spondylitis, Inflammatory bowel diease, Reiter's syndrome (PAIR)
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HLA-B8
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Graves' disease
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HLA-DR2
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Multiple sclerosis, hay fever, SLE, Goodpasture's
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HLA-DR3
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Diabetes mellitus type 1
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HLA-DR4
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Rheumatoid arthiritis, diabetes mellitus type 1
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HLA-DR5
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Pernicious anemia --> B12 deficiency, Hashimoto's thryoiditis
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HLA-DR7
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Steroid-responsive nephrotic syndrome
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Main antibody in delayed response to antigen, Most abudandt isotype in the blood, Fixes complement, Crosses the placenta, Opsonizes bacteria, neutralizes bacterial toxins and viruses
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IgG
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Prevents attachment of bacteria and viruses to mucous membranes, does not fix complement, found in secretions, monomer in circulation, dimer when secreted
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IgA
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Prodcued in immediate response to antigen, fixes complement but does not cross the placenta, antigen receptor on surface of B cells, pentamer
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IgM
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Unclear fxn, found on surface of B cells and in serum
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IgD
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Binds mast cells and basophils, cross links when exposed to antigen, type 1 hypersensitivity, activate eosinophils, lowest concentration in serum
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IgE
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Secreted by macrophages, causes acute inflammation, induces chemokine production to recruit leukocytes, activates endothelium to express adhesion molecules, endogenous pyrogen
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IL-1
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Secreted by Th cells, stimulates growth of helper and cytotoxic T cells
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IL-2
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Secreted by activated T cells, supports the growth and differentiation of bone marrow stem cells
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IL-3
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Secreted by Th2 cells, promotes growth of B cells, enhances class switching to IgE and IgG
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IL-4
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Secreted by Th2 cells, promotes differentiation of B cells, enhances class switching to IgA, stimulates production and activation of eosinophils
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IL-5
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Secreted by Th cells and macrophages, stimulates production of acute-phase reactants and immunoglobulins
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IL-6
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Secreted by macrophages, major chemotactic factor for neutrophils
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IL-8
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Secreted by regulatory T cells, inhibits actions of activated T cells, activates Th2 and inhibits Th1
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IL-10
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Secreted by B cells and macrophages, Activates NK cells and Th1 cells
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IL-12
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Secreted by Th1 cells, stimulates macrophages, activates Th1 and inhibits Th2
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INF-Gamma
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Secreted by macrophages, mediates septic shock, causes leukocyte recruitment, vascular leak
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TNF
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Anaphylactic and atopic; free antigens cross links IgE on msat cells and basophils triggering release of vasoactive amines; reaction develops rapidly after exposure to antigen
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Type 1 Hypersensitivity
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Antibody mediated; IgM, IgG bind to fixed antion on enemy cell leading to lysis or phagocytosis
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Type 2 Hypersensitivity
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Immune complex mediated; antigen-antibody (IgG) complex activates complement, which attract neutrophils, neutrophils relase lysosomal enzymes
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Type 3 Hypersensitivity
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Delayed (T cell mediated); sensitized T lymphocytes encounter antigen and then release lymphokines to lead to macrophage activation
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Type 4 Hypersensitivity
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Type 1 Hypersensitivity Disorders
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Anaphylaxis and allergic/atopic disorders
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Type 2 Hypersensitivity Disorders
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Hemolytic anemia, Pernicious anemia, Idiopathic thrombocytopenia purpura, Erythroblastosis fetalis, Acute hemolytic transfusion reactions, Rheumatic fever, Goodpasture's syndrome, Bullous pemphigoid, Pemphigus vulgaris, Graves' disease, Myasthenia gravis
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Type 3 Hypersensitivity Disorders
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SLE, RA, Polyarteritis nodosa, Poststreptococcal glomerulonephritis, Serum sickness, Arthus reaction, Hypersensitive pneuomonitis
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Type 4 Hypersensitivy Disorders
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Type 1 DM, Multiple sclerosis, Guillain-Barre syndrome, Hashimoto's thyroiditis, Graft-verus-host disease, PPD for M. tuberculosis, Contact dermatitis
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Defective CD40L on Th cells, which leads to inability to class switch; Sever pyogenic infections early in life; inc. IgM, dec. IgG, IgA, and IgE
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Hyper-IgM syndrome
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Dec. Th1 response, Disseminated mycobaterial infections, dec. IFN-gamma
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IL-12 receptor deficiency
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Th cells fail to produce IFN-gamma --> inability of neutrophils to respond to chemotactic stimuli, FATED (coarse Facies, cold staph Abscesses, retained primary Teeth, inc. IgE, Derm problems)
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Hyper IgE syndrome (Job's syndrome)
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T cell dysfunction, Candida albicans infections of skin and mucous membranes
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Chronic mucocutaneous candidiasis
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Defect in LFA-1 integrin (CD18) protein on phagocytes; recurrent bacterial infections, absent pus formation, delayed separation of umbilicus; neutrophilia
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Leuokocyte adhesion deficiency (type 1)
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Autosomal recessive; defect in microtubular function with dec phagocytosis; recurrent pyogenic infections by staph and strep, partial ablinism, peripheral neuropathy
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Chediak-Higashi syndrome
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Lack of NADPH oxidase --> dec reactive oxygen species and absent respiratory burst in neutrophils; inc susceptibility to catalase-positive organisms; negative nitroblue tetrazolium dye reduction test
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Chronic granulomatous disease
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Binds to cyclophilins. Complex blocks the differentiation and activation of T cells by inhibiting calcineurin, thus preventing production of IL-2 and its receptor
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Cyclosporine
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Binds to FK-binding protein, inhibiting secretion of IL-2 and other cytokines
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Tacrolimus (FK506)
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Antimetabolite precursor of 6-mercaptopurine that interferes with metabolism and synthesis and nucleic acids; toxic to proliferation lymhocytes
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Azathioprine
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Monoclonal antibody that binds CD3 on the surface of T cells. Blocks celler interactios of CD3 protein responsible for T cell signal transduction
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Muromonab-CD3 (OKT3)
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Binds to mTOR. Inhibits T cells proliferation in response to IL-2
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Sirolimus (rapamycin)
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Inhibits de novo guanine synthesis and blocks lymphocyte production
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Mycophenolate mofetil
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Monoclonoal antibody with high affinity for IL-2 receptor on activated T cells
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Daclizumab
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