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53 Cards in this Set

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  • Back
azathioprine
general growth inhibitor, metabolized to mercaptopurine -> inhibits purine syn & incorporates into DNA, inactivated by xanthine oxidase/allopurinol
cyclophosphamide
general growth inhibitor, cross-links DNA killing proliferative cells
leflunomide
general growth inhibitor, a prodrug, active metabolite inhibits dihydroorotate dehydrogenase
methotrexate
general growth inhibitor, inhibits dihydrofolate reductase
mycophenolate mofetil
general growth inhibitor, metabolized to mycophenolic acid -> inhibits inosine monophosphate dehydrogenase preventing purine syn.
prednisone
glucocorticoid
sirolimus
mTOR (target of rapamycin) inhibitor
cyclosporine
calcineurin inhibitor
tacrolimus
calcineurin inhibitor
anti-lymphocyte globulin
antibody, blocks T cell surface receptors and opsonizes T cell
muromonab-CD3
antibody, blocks and opsonizes TCR
basiliximab
antibody, anti-IL-2 receptor (anti-CD25), only affecting T cells that have been activated
daclizumab
antibody, anti-IL-2 receptor (anti-CD25), only affecting T cells that have been activated
RH(d) immune globulin
antibody, competitively binds Rh antigen to prevent naïve B cell activation
interleukin-2
cytokine, inc. prolif of activate T cells -> INF-gamma, cytotoxic killing
interferon-gamma
cytokine, stimulates cell mediated cytotoxic response
BCG
adjuvant
cetirizine
H1 antihistamine (second generation)
dimenhydrinate
H1 antihistamine (first generation)
diphenhydramine
H1 antihistamine (first generation), antimuscarinic affects, block sodium channels (local anesthesia)
fexofenadine
H1 antihistamine (second generation)
loratadine
H1 antihistamine (second generation)
meclinzine
H1 antihistamine (first generation)
promethazine
H1 antihistamine (first generation), antimuscarinic affects, block sodium channels (local anesthesia)
terfenadine
H1 antihistamine (original prodrug desing of fexofenadine with fatal arrhythmia problem)
adalimumab
human anti-TNF alpha antibody
infliximab
humanized anti-TNF alpha antibody
etanercept
anti-TNF alpha agent, fusion protein of TNF ligand binding domain and human Fc domain
aspirin
COX nonselective inhibitor
diclofenac
COX nonselective inhibitor
diclofenac with misoprostol
COX nonselective inhibitor
ibuprofen
COX nonselective inhibitor
indomethacin
COX nonselective inhibitor
ketorolac
COX nonselective inhibitor
naproxen
COX nonselective inhibitor
acetaminophen
COX nonselective inhibitor
celecoxib
COX-2 selective inhibitor
rofecoxib
COX-2 selective inhibitor
albuterol
beta 2 agonist
salmeterol
beta 2 agonist
salmeterol with fluticasone
beta 2 agonist
beclomethasone
corticosteroid
budesonide
corticosteroid
fluticasone
corticosteroid
triamcinolone
corticosteroid
montelukast
LTD4 receptor antagonist
zafirlukast
LTD4 receptor antagonist
zileuton
inhibits 5 lipoxygenase and leukotriene syn. (LTB4 and LTD4 in mast cells and eosinophils)
cromolyn
inhibits Ca2+ dependent mast cell degranulation and inhibits Cl- channels
nedocromil
inhibits Ca2+ dependent mast cell degranulation and inhibits Cl- channels
ipratropium
muscarinic cholinergic antagonist
omalizumab
anti-IgE antibody
theophylline
a methylxanthine: PDE inhibitor (relaxes smooth muscle) & adenosine receptor blocker