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53 Cards in this Set
- Front
- Back
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azathioprine
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general growth inhibitor, metabolized to mercaptopurine -> inhibits purine syn & incorporates into DNA, inactivated by xanthine oxidase/allopurinol
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cyclophosphamide
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general growth inhibitor, cross-links DNA killing proliferative cells
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leflunomide
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general growth inhibitor, a prodrug, active metabolite inhibits dihydroorotate dehydrogenase
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methotrexate
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general growth inhibitor, inhibits dihydrofolate reductase
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mycophenolate mofetil
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general growth inhibitor, metabolized to mycophenolic acid -> inhibits inosine monophosphate dehydrogenase preventing purine syn.
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prednisone
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glucocorticoid
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sirolimus
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mTOR (target of rapamycin) inhibitor
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cyclosporine
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calcineurin inhibitor
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tacrolimus
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calcineurin inhibitor
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anti-lymphocyte globulin
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antibody, blocks T cell surface receptors and opsonizes T cell
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muromonab-CD3
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antibody, blocks and opsonizes TCR
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basiliximab
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antibody, anti-IL-2 receptor (anti-CD25), only affecting T cells that have been activated
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daclizumab
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antibody, anti-IL-2 receptor (anti-CD25), only affecting T cells that have been activated
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RH(d) immune globulin
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antibody, competitively binds Rh antigen to prevent naïve B cell activation
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interleukin-2
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cytokine, inc. prolif of activate T cells -> INF-gamma, cytotoxic killing
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interferon-gamma
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cytokine, stimulates cell mediated cytotoxic response
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BCG
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adjuvant
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cetirizine
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H1 antihistamine (second generation)
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dimenhydrinate
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H1 antihistamine (first generation)
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diphenhydramine
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H1 antihistamine (first generation), antimuscarinic affects, block sodium channels (local anesthesia)
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fexofenadine
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H1 antihistamine (second generation)
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loratadine
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H1 antihistamine (second generation)
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meclinzine
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H1 antihistamine (first generation)
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promethazine
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H1 antihistamine (first generation), antimuscarinic affects, block sodium channels (local anesthesia)
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terfenadine
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H1 antihistamine (original prodrug desing of fexofenadine with fatal arrhythmia problem)
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adalimumab
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human anti-TNF alpha antibody
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infliximab
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humanized anti-TNF alpha antibody
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etanercept
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anti-TNF alpha agent, fusion protein of TNF ligand binding domain and human Fc domain
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aspirin
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COX nonselective inhibitor
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diclofenac
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COX nonselective inhibitor
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diclofenac with misoprostol
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COX nonselective inhibitor
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ibuprofen
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COX nonselective inhibitor
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indomethacin
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COX nonselective inhibitor
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ketorolac
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COX nonselective inhibitor
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naproxen
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COX nonselective inhibitor
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acetaminophen
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COX nonselective inhibitor
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celecoxib
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COX-2 selective inhibitor
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rofecoxib
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COX-2 selective inhibitor
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albuterol
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beta 2 agonist
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salmeterol
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beta 2 agonist
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salmeterol with fluticasone
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beta 2 agonist
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beclomethasone
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corticosteroid
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budesonide
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corticosteroid
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fluticasone
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corticosteroid
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triamcinolone
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corticosteroid
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montelukast
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LTD4 receptor antagonist
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zafirlukast
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LTD4 receptor antagonist
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zileuton
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inhibits 5 lipoxygenase and leukotriene syn. (LTB4 and LTD4 in mast cells and eosinophils)
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cromolyn
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inhibits Ca2+ dependent mast cell degranulation and inhibits Cl- channels
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nedocromil
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inhibits Ca2+ dependent mast cell degranulation and inhibits Cl- channels
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ipratropium
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muscarinic cholinergic antagonist
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omalizumab
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anti-IgE antibody
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theophylline
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a methylxanthine: PDE inhibitor (relaxes smooth muscle) & adenosine receptor blocker
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