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10 Cards in this Set
- Front
- Back
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IL-2
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made by T-helper cells
and is T-cell growth factor |
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IL-4
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made by Th2 cells and mast cells
promotes IgE and IgG synthesis promotes Th2 and B-cells inhibits Th1 |
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IL-5
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produced by Th2 and mast cells
promotes B-cell growth and Ig secretion (humoral arm) |
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IL-10
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produced by Th2 and macrophages
inhibits production of Th1 and macrophage |
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IL-12
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produced by B-cells and macrophage
activates NK cell and promotes Th1 production- activates cell mediated immunity |
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IL- 1
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produced by monocytes and others
promotes proliferation of Th2 cells and induces fever and acute phase protein |
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IL-6
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made by t-cell, macrophages and others
activates T-cells to produce IL-12 --> cell mediated immunity induces fever and IgG production (so stimulates both arms) |
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TNF-alpha
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produced by macrophages and mast cells
induce fever and septic shock enhance expression of selectins and ICAMs on endothelial cells that bind selectins on neutrophils |
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Chemokines
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peptides active at low conc. 2 groups based on cycstein
C-X-C most attract neutrophils and an ex is IL-8 C-C most attract monocytes and T-lymphocytes, and a couple attract eosinophils and basophils and NK cells. |
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what are the cytokines that promote hematopoesis
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IL-3- granulocytes, macrophage, megakaryocytes, mast cells and erythrocytes
IL-7 induces B and T cells proliferation- lyphoid progenitors G-CSF M-CSF GM-CSF |
