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28 Cards in this Set
- Front
- Back
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disease association with type I hypersensitivity?
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asthma
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disease association with type II hypersensitivity?
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hyperthyroid, MG, goodpasture
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disease association with type III hypersensitivity?
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post-strep glomeruoneph., vasculitis, SLE
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disease association with type IV hypersensitivity?
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poison ivy, TB, hepatitis, RA, sarcoidosis
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AIRE gene?
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expresses non-thymic self-antigen in thymic epithelial cells
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what special change in tolerance can be seen in B-cell tolerance, but not T-cell tolerance?
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receptor editing
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cytokines that downregulate response include?
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TGF-beta, IL-10
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cell apoptosis mediated by what gene?
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Fas and FasL
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hematologic manifestations of SLE caused by which type hypersensitivity?
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type II
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specific HLA genes involved in SLE?
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HLA-DR2,3
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what does Fc receptors in liver and spleen bind to?
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IgG of immune complex
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down-regulatory molecule found on T cells?
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CTLA4
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estrogen role in SLE?
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possible stimulate lymphocytes
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specific ANA molecules diagnostic of SLE?(2)
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Anti-ds DNA, Anti-Sm
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corticosteroids block which pro-inflammatory cytokine gene?
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NFKappaB
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which immunosuppresant is purine analogue?
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azathioprine
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which immunosuppresant is alkylating agent?
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cyclophosphamide
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which immunosuppresant is folic acid antagonist?
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methotrexate
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which drug binds to CD20 on B cells?
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rituximab
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which type hypersensitivity involved in synovial fluid of RA?
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type III
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which gene has strong association with RA?
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HLA-DR4
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rxn. to infection in RA is what kind of cell expansion?
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oligoclonal expansion of T cells
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anti-CCP? uses?
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antibodies to citrulline, deaminated arginine via peptidylarginine deaminase, attack normal via "epitope spreading";
more specific test for RA than RF |
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which t cell often found in synovium of RA patients?
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Th17 cells, also found in other autoimmune disease
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roles of TNF and IL-1?
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activate osteoclasts and adhesion molecules, and MMP secretion from macrophages
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which drug collects TNF to prevent it from activation?
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etanercept
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IL-1 receptor antagonist?
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anakinra
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recombinant CTLA4?
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abatacept
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