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58 Cards in this Set
- Front
- Back
Name and describe the 7 cell types of the innate immune system |
a. Neutrophils aka granulocytes or PMN (most common type of leukocyte) |
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Describe the two pathways by which the innate immune system recognizes danger |
1. The mannose binding protein from the liver binds to mannose in bacterial cell walls resulting in the uptake by phagocytic cells. |
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What are the 4 cardinal characteristics of the adaptive immune system? |
1. recognizes antigens on pathogens (very specific) |
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what are the cells of the adaptive immune system |
1. macrophages and dendritic cells - phagocytize antigen and processes portions to be displayed as a red flag triggering the immune response |
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Describe the characteristics of SC |
Stem cells are cells in G0 stage of cell cycle that can be induced to divide to produce more of itself or differentiate. |
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Describe the structural and fx characteristics of stem cells and compare them with progenitor, precursor and mature circulating blood cells |
SC |
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What are PHASC and where are they found? |
PHASC are Pluripotent HemAngiogenic Stem Cell |
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How do the dendritic cells initiate adaptive immune response? |
DC take up macropinocytosis and receptor-mediated endocytosis. DC cells are stimulated -> travel through the lymphatics to regional lymph nodes -> by then they are mature nonphagocytic DCs that express both antigen and the necessary surface molecules to stimulate clonal expansio also activates antigen-specific naive T lymphocytes. |
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How are B cells activated when they encounter antigen? |
B cells encountering antigens in secondary lymphoid tissues form germinal centers and undergo differentiation to plasma cells. |
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What is the fx of M cells in the GI tract? |
M cells are present in the dome shaped covering of Peyer's patches. |
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Describe the path of Lymphocyte traffic. |
Lymphocytes leave the blood thru High Endothelial Venules in lymph nodes and Peyer's Patches -> enter efferent lymphatics and the thoracic duct system which joins the left subclavian and internal jugular veings. |
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How are erythrocytes formed from stem cells? |
Erythropoietin from the kidney causes CFC-GEMM to become CFC-erythroid -> Proerythroblast -> Erythrocyte |
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How are Platelets formed? |
Thrombopoietin from the liver causes CFC-GEMM to become CFC-Megakaryote -> Megakaryoblast -> Megakaryoctye -> Platelets |
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How are Basophils formed? |
CFC-GEMM is stimulated by IL-4 to become CFC-Basophil -> Myeloblast -> B. Stab -> Basophil |
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How are Eosinophils formed? |
CFC-GEMM is stimulated by IL-5 to become CFC-Eosinophil -> Myeloblast -> E. Stab -> Eosinophil |
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How are Neutrophils formed? |
CFC-GEMM is stimulated by GM-CSF to become CFC-NM. |
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How are Monocytes formed? |
GM-CSF stimulates CFC-GEMM to become CFC-NM which is stimulated by M-CSF to become CFC-Monocyte -> monoblast -> Monocyte |
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How are dendritic cells formed? |
GM-CSF, IL-4, Flt3-ligand cause CFC-NM to become CFC-Dendritic Cell -> Immature Dendritic Cell (Langerhan's Cell of Skin) |
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How are T cells formed? |
IL 7& IL 2, 6 CAUSES CFC-Ly to become CFC-T/NK -> preT -> Thymus -> T-cell |
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How are NK cells formed? |
IL 7 & IL 2, 12 causes CFC-Ly to become CFC-T/NK ->preNK -> NK cell |
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How are plasma cells formed? |
IL-7, SCF causes CFC-Ly to become CFC-B ->pro B -> pre B -> immature B -> mature B. |
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Define Innate Immunity |
our non-adaptive, global host defense against pathogens. |
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Describe the recognition mechanisms used by leukocytes to ID pathogens |
TLR on DC binds PAMPs activate an immune response |
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ID the key components of the inflammatory process |
1. increased blood flow -> vasodilation = more serum mediators and white cells |
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Understnd how the innate and the adaptive system interact to produce optimal immune responses |
1. Dendritic cells: phagocytize antigens, signal adaptive system based on TLR activation, secretes cytokines |
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What is opsonization? |
coating of particles by molecules that enhance recognition by phagocytes. |
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anatomic course of adaptive immunology ... ie the path of antigen introduction to end result |
1. Antigens derived from pathogens are either delivered to the lymph nodes/spleen system by DC or via the blood. |
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Describe usual routes of immunization and adjuvant for B cell immunity |
Route of immunization and adjuvant |
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Describe T cell-dependent antigens |
Surface Ig serves as BCR -> interacts with antigen -> internalized -> BCR + antigen degraded intracellularly. |
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Describe T cell-independent antigens |
some examples are bacterial lipopolysaccharide, polymerized flagellin, Pneumococcal polysaccharides, dextrans, levans, and hyaluronic acid |
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Describe the mechanism by which antibodies protect the host from pathogens |
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Describe the function of germinal centers in humoral immunity |
Germinal centers form in secondary lymphoid tissue during immune responses |
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Describe the sequence of events that occur in germinal centers during T cell-dependent immune repsonses |
BCR binds antigen |
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Describe the sequence of events leading from interaction of a B cell with a T cell-dependent antigen to production of high affinity IgG antibody. |
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Compare and contrast primary and secondary immune responses |
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Describe how Fc and complement receptors participate in immune responses |
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Describe how ITAMs of the BCR contribute to B cell activation |
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what |
large size |
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What are some adjuvants used to enhance immune responses? |
Alum plus Bordetella pertussis |
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B cell activation requires 2 signals |
For T cell-dependent antigens these two signals are: |
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Activation of TH cells by interaction of TCR with peptide/MHC II complex triggers T cells to: |
Activation of TH cells by interaction of TCR with peptide/MHC II complex triggers T cells to: |
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What is one this both B and T cell must do in order to work? |
For T cell-dependent antigens |
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How does the influenza type B vaccine work? |
-protective antibody is specific for the bacterial polysaccharides |
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What are the differences between the primary and secondary antibody response? |
Primary antibody responses are slow and mostly of IgM isotype |
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Describe isotype switching |
Isotype switching occurs during T-cell dependent antibody responses |
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For isotype switching |
IL-4 causes expression of IgG1 and IgE for secondary response and allergic hypersensitivity |
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For isotype switching |
IFN-γ induces IgG2a and IgG3 expression |
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For isotype switching |
Induces IgG2b AND IgA for secondary response and external mucus secretions |
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Antibody responses to T cell independent antigens include |
Antibodies are predominantly IgM isotype |
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What are ITAMs? |
Immunoreceptor tyrosine-based activation motifs |
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BCR signaling |
cross-linking of BCRs by antigen triggers a signal transduction cascade |
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Destruction of Antibody coated pathogens |
complement and Fc Receptor mediated clearance of pathogens |
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which of the following is characteristic of an immune response to protein antigens |
Answer is E |
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Describe the steps by which B cells are activated to proliferate and differentiate in response to T cell -dependent antigens. |
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Describe how B cells are activated in response to T cell-independent antigens |
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State the fx of CD40L on T cells and consider the immunologic profile of a person with defective CD40L |
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Describe how Fc and complement receptors contribute to destruction of pathogens pneumococcal polysaccharide? with tetanus toxoid? |
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How do antibodies contribute to protection against and recovery from bacterial and viral infections? |
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