Immuno 3

Front 1

what can antigen receptors of B cells recognize

Back 1

wide variety-proteins, polysaccharides, lipids, nucleic acids, small chemicals in soluble or cell-surface associated form

Front 2

T cells can recognize

Back 2

only peptide fragments of protein antigens-and only when presented by specialized peptide display molecules on host cells (MHC restriction)

Front 3

how do microbes stimulate innate immune response via dendritic cells

Back 3

bind TLRs and other sensors of microbes on dendritic cells

Front 4

what activates dendritic cells

Back 4

combination of TLR signaling and cytokines

Front 5

activated dendritic cell characteristics

Back 5

lose adhesiveness for epithelia and begin to express surface receptor CCR7

Front 6

CCR7

Back 6

specific for chemoattracting cytokines produced in T cell zones of lymph nodes; direct dendritic cells to lymphatic vessels to lymph nodes

Front 7

T lymphocyte recirculation

Back 7

continuously recirculate through lymphocytes, also express CCR7 which promotes entry into T cell zones of lymph nodes

Front 8

efficiency of dendritic cell/T cell interactions in lymph nodes

Back 8

T cell response to antigens within 12-18 hours

Front 9

dendritic cell activation of T cells

Back 9

not only activate, but influence differentiation into distinct populations

Front 10

B cells ingest protein antigens and display them to helper T cells wihtin lymphocytes, this is important for

Back 10

dvlp of humoral immune responses

Front 11

cell-mediated immune rxns with macrophages and T cells

Back 11

macrophages display antigens of phagocytosed microbes and display to t cells which activate macrophages to kill microbes

Front 12

what can nucleated cells present antigens derived from microbes in cytoplasm to

Back 12

CTLs

Front 13

cross-presentation

Back 13

dendritic cells ingest infected cells and display antigens present in infected cells for recognition by CD8+ cells

Front 14

human MHC proteins are called

Back 14

human leukocyte antigens (HLAs)

Front 15

class I molecules

Back 15

alpha chain noncovalently attached to a protein B2-macroglobulin; amino terminal a1 and a2 domains form peptide binding cleft/groove large enough to accomadate 8-11 aas

Front 16

alpha3 domain of class 1

Back 16

invariant and contains binding site for T cell co-receptor CD8

Front 17

class II molecules

Back 17

2 chains, alpha and beta-both contain polymorphic residues and form a celft large enough to accommodate peptides of 10-30 residues

Front 18

nonpolymorphic B2 domain of class II

Back 18

binding site for T cell coreceptor CD4

Front 19

MHC gene expression for class I

Back 19

codominant; HLA-A, B, and C with 2 different sets (one from eash parent)=6 different class I molecules

Front 20

Mhc gene expression for class II

Back 20

HLA-DP (DPA1 and DPB1), HLA-DQ (DQA1 and DQB1), HLA-Dra (DRA1), and one or two HLA-DRB (DRB1, DRB3, 4 or 5)=6 or 8 class II alleles (3 or 4 from each parent)

Front 21

where are class I molecules expressed

Back 21

all nucleated cells

Front 22

where are class II molecules expressed

Back 22

mainly on dendritic cells, macrophages, and B lymphocytes; also thymic epithelial cells and endothelial cells

Front 23

what can induced class II molecule expression

Back 23

cytokine interferon-gamma

Front 24

specificity of MHC binding for peptides

Back 24

broad-can bind many, but not all possible peptides

Front 25

where do class I aquire peptides to present

Back 25

cytosolic proteins

Front 26

where do class II aquire peptides to present

Back 26

proteins in intracellular vesicles

Front 27

antigen processing

Back 27

mechanism for converting naturally occuring proteins into peptides able to bind to MHC molecules

Front 28

where do APCs synthesize class II MHC molecules

Back 28

ER

Front 29

CLIP

Back 29

class II invariant chain peptide; binds class II binding cleft

Front 30

class II-like protein called DM

Back 30

removes CLIP from class II molecule

Front 31

immunodominant epitopes

Back 31

peptides derived from intact antigen stimulate immune responses in individual

Front 32

transporter associated with antigen processing (TAP)

Back 32

located in ER membrane-binds peptides from cytoplasm and actively pumps them across ER membrane into interior of ER-now they can be captured by MHC class I molecules

Front 33

what does segregation of class I and II antigen presentation achieve

Back 33

ensures correct, specialized immune response against microbes in different locations

Front 34

follicular dendritic cell fxn

Back 34

display antigens to activated B cells

Front 35

what do NK cells recognize

Back 35

lipids displayed by class I-like CD1 molecules