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22 Cards in this Set
- Front
- Back
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Classic examples of antigen variation
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Bact - Salmonella, Borrelia, Neisseria gon
Viral - Influenza Parasites - trypanosomes (programmed rearrangement) |
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Examples of passive immunity
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IgA in breast milk, antitoxin, humanized monoclonal antibody
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Examples of active immunity
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natural infection, vaccines, toxoid
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Serotonin and the immune system
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Released with histamine from platelets
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Fungal infection if B-cell (IgA) deficient
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Giardia
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Immunodeficiency with milk allergy and diarrhea
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Selective IgA deficiency
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Defect in B cell maturation
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Common Variable Immunodeficiency
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Disseminated mycobacterial infections
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IL-12 receptor deficiency
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Th cells fail to produce IFN-y
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Neutrophils cannot respond to chemotactic stimuli - Hyper IgE syndrome
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Defective IL-2
Failure to synthesize MHCII |
SCID (Also Adenosine deaminase deficiency)
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Which Ig is deficient in Ataxia-Telangiectasia?
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IgA
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XLR and progressive deletion of B and T cells
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Wiskott-Aldrich Syndrome
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Neutrophils cannot exit the circulation; absent pus formation
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Leukocyte Adhesion Deficiency
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Chediak Higashi Triad
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Partial albinism
Recurrent Pyogenic infections Peripheral neuropathy |
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Nitroblue tetrazolium test
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Chronic Granulomatous Disease
Yellow - no NADPH present Blue - NADPH present! |
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Syngeneic graft
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From identical twin or clone
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Xenograft
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from different species
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Rejection with maculopapular rash, hepatosplenomegaly, jaundice, and diarrhea
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GVHD (host cells recognized as foreign)
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How can you prevent nephrotox from Cyclosporine?
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Mannitol
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Aldesleukin
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IL-2 used to Rx: RCC, metastatic melanoma
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Oprelvekin
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IL-11 to rx thrombocytopenia
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Omalizumab
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monoclonal antibody that targets IgE
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