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28 Cards in this Set
- Front
- Back
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IgA |
Found mostly in secretions 6 day half life |
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IgG |
Most abundant Ig in serum Crosses placenta 21 day half life |
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IgM |
First AB formed in an immune rx Can be produced by fetus |
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IgD |
Found on Bcell |
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IgE |
Small amounts in serum Once bound to a cell half life ⬆ Important for allergic reaction |
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T cells |
Diff into t helper and t cytotoxic Assc with cell mediated immunity Differentiate in thymus |
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APCs |
Antigen presenting cells Present antigens to t cells |
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Phagocytes |
Macrophages and neutrophils |
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Cytokines |
Activated by lymphs and phagocytes Mediate immune response Can enter cell to kill pathogen |
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Normal flora |
Take up space Use nutrients Excrete waste |
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First line of defense |
Skin and mucous membranes |
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Second line of defense |
Inflammatory response |
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PMNS |
Neutrophils Usually die in the process Phagocytosis at the site of infection |
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Steps to phagocytosis |
Chemotaxis Attachment Ingestion Digestion |
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Complement |
18 blood proteins produced by the liver |
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Acute phase proteins |
CRP Interleukin Alpha 1 antitrypsin C3 |
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CRP |
100-1000 fold increase w/in hours of tissue damage Binds to damages cells and microbes to activate complement |
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Interleukin |
Made by WBCs Migration of WBC to area Production and maturation of WBC |
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Alpha 1 antitrypsin |
Breaks down enzymes released by WB |
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C3 |
Is an opsonin |
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Third line of defense |
Specific immune response Humoral and cell mediated |
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Exogenous |
Outside the body Bacteria,virus,fungus Pollen, dander |
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Endogenous |
Within the body Malignant,tumor cells Senescent cells old/dead |
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Recognizing antigens |
B cells can recognize and bind Ag in its natural form T cells only recognize after APC presentation |
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B cell activation |
Direct recognition of antigen or By activated T cells |
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T helper cells |
Promote inflammation B cell proliferation Activate macrophages Enhance natural killer cells |
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T cell activation |
T cell binds to APC and is activated Produces cytokines which activate other cells |
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Cell mediated immunity |
Protect against intracellular pathogens and malignant cells |
