Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Innate/non-specific immunity
|
- Skin (mechanical barriers)
- Mucous Membranes - Iron-binding proteins - Phagocytosis |
|
|
Phagocytes
|
- polymorphonuclear white blood cells
- monocytes - Fixed macrophages |
|
|
Iron Binding Proteins
|
- transferrin
- lactoferrin -prevents bacteria from getting iron needed for growth |
|
|
Specific Immunity
|
-Humoral Immunity
- Cell Mediated Immunity - Directed against one particular species of microorganism and not any other |
|
|
Humoral Immunity
|
- Depends upon circulating antibodies made based on previous encounters with invading organisms
|
|
|
Antibody
|
Protein that binds to a specific antigen produced by B lymphoctes (plasma cells).
- Immunoglobulins |
|
|
Antigen
|
-Foreign Substance
- Can be protein, glycoprotein, lipoprotein, polysaccharide -molecular weight at least 10,000 to trigger response |
|
|
Ig G
|
- Y- Shaped molecule with two combining sites for antigens
- the rest hooks onto phagocytes and marophages. - - Crosses placenta to protect newborns |
|
|
Ig M
|
- made of five units joined (pentamer)
- Main immuneglobulin in early response - Doesn't cross placenta |
|
|
Ig A
|
- Found in secretions (e.g. milk, tears, gastro, urinary, mucoasae)
- dimer |
|
|
Ig E
|
-best for parasite response
- factor in hypersensitivity |
|
|
Cell-Mediated Immunity
|
- exposure to antigen induces production of trained cells
- based on T-Cell subpopulations and a complex system o f interactions |
|
|
What are some disorders of Immunity?
|
- Allergy and hypersensitivity
- Auto-immune - Immunodeficiency - Graft rejection |
|
|
Allergy and hypersensitivity
|
-overreaction to antigens that don't cause infection
-anaphylaxis |
|
|
Auto-immune
|
-individuals react against self tissue
|
|
|
Immunodeficiency
|
-lakc the ability to produce antibodies, CMI or both
-AIDS congenital diseases, irradiation |
|
|
Graft rejection
|
-immune system see's transplanted tissue as antigen
|
|
|
What is the purpose of studying the serological reaction?
|
-Detects presence of antibodies in serum sample
-antibody titration -can detect unknown microorganisms using known antisera |
|
|
Define aggluntination
|
Antigen and antibody interaction
|
