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33 Cards in this Set
- Front
- Back
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innate immunity
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defenses against any pathogen
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adaptive immunity
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induced resistance to a specific pathogen
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3rd line of defense
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lymphocytes: bcells - humoral immunity & t cells cellular immunity
circulate in blood or lymph migrate to secondary lymphoid tissues like lymph nodes or spleen |
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bcells
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made mature in bone marrow
humoral immunity antibodies activation |
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tcells
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made mature in thymus
cellular immunity physical attack |
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antibodies
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interact with epitopes or antigenic determinants
secreted by plasma cells (b cells) part of humoral immune response 4 peptide chains - 2long 2 short w/ s-s bonds MADGE |
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IgG
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monomer
80% serum Ab's blood lymph intestine cross placenta enhance phagocytosis, neutralize virus/toxins, protect newborn 1/2 life 23 days |
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IgM
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pentamer
5-10% serum Ab's blood, lymph on B cells agglutinate microbes - 1st Ab produced in response 1/2 life 5 days |
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IgA
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Dimer
10-15% serum Ab's secretions mucosal protection 1/2 life 6 days |
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IgD
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monomer
.2% serum Ab's blood lymph bcells 1/2 life 3 days |
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IgE
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monomer
.002% serum Ab's mast cells, basophils, blood allergic, lysis of parasitic works 1/2 life 2 days |
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antibody functions
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bind to antigens
eliminate Ag protective agglutinate - decr # units for infection |
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protective effect of Ag-Ab binding
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agglutination
activation of complement opsonization neutralization Ab dependent, cell mediated cytotoxicity |
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agglutination
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decr # infection particles
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activation of complement
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causes inflammation and cell lysis
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opsonization
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coating Ag with Ab enhances phagocytosis
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Ab dependent, cell mediated cytotoxicity
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Ab attach to target cell, cause destruction of eosenophils and NK cells
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neutralization
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block adhesion of bac and viruses to mucosa & blocks attachment of toxin
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antigens
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substance that cause body to produce specific antibodies or sentized tcells
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Good antigen is
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right size
solid shape good complexity high molecular weight |
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3 types of antigen
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exogenous
endogenous autoantigens |
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exogenous
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found on external surface of pathogens (usually bacteria)
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endogenous
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found on inside of virally infected cells (virus on inside of cell)
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autoantigens
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normal cells to start to have antigens on them (auto immunity)
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haptens
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hapten mol + carrier mol
not good by itself |
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stem cell
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fr bone marrow or fetal liver
2 cell lines: red bone marrow in adults to bcell & thymus to Tcells migrate to lymphoid tissue such as spleen but especially lumph nodes |
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activation of B cells
plasma cells |
secrete pro Ab or Ig
make up majority of cells prod during b cell proliferation secretes only Ab mol complementary to specific antigenic determinant short lived cells that die w/in few days of activation Ab and progeny can presist |
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activation of B cells
memory cells |
prod by bcell proliferation that do not secrete Ab
cells that have BCR's complementary to specific Ag determinant that triggered their prod long lived cells divide only few times & persist in lymphoid tissue avail to initiate Ab prod if same Ag is encountered again |
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colonial deletion
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eliminates harmful B cells
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Immunological memory
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antibody titer
primary response secondary response |
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antibody titer
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amt of Ab in serum
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primary response
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occurs after initial contact w/ Ag
Day 5 IgM Day 15 IgG |
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secondary response
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occurs after secondary exposure
Day 6 IgM Day 7 IgG (HIGH) faster, vigorous, higher response |
