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15 Cards in this Set
- Front
- Back
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igM |
pentamer (largest) first to respond potent agglutinating agent (clumps stuff) readily fixes and activates compliment |
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igA |
secretory monomer or dimer(2),in mucus and other secretions helps prevent entry of pathogens breast milk stops pathogens from attaching to epithelial surfaces |
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igD |
monomer, attached to surface of B cells B cell receptor |
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igG |
monomer, 75-85% of antibodies in plasma (most) crosses placental barrier, passive immunity secondary and late primary response |
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igE |
monomer, allergic and parasitic reactions cause mast cells and basophils to release histamine |
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antibodies (immunoglobins) |
gamma globulin portion of blood proteins secreted by plasma cells capable of binding specifically with antigen detected by B cells grouped into one of five classes |
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basic antibody structure |
T or Y shaped antibody monomer if four looping polypeptide chains linked by disulfide bonds 2 identical heavy chains 2 identical light chains five variable regions |
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B cells |
can switch antibody classes, but not antigen specificity igm at first then igg almost all secondary responses are igg
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neutralization |
simplest defense antibodies block specific sites on viruses or bacterial exotoxins prevent these antigens from binding to receptors on tissue cells antigen-antibody complexes undergo phagocytosis |
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antibody target/ function |
inactivate and tag antigens, do not destroy them defense mechanisms (neutralization, agglutination, precipitation, complement fixation) |
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agglutination |
antibodies bind same determinant on more than one cell bound antigen cross linked antigen antibody complexes agglutinate |
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precipitation |
soluble molecules are cross linked complexes precipitate and are subject to phagocytosis |
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complement fixation |
main antibody defense against cellular antigens (bacteria, mismatched rbc) several antibodies bind together on cellular antigen, complement binding sites on stem regions align, triggers complement fixation into cells surface, cell lysis amplify inflammatory response, promotes phagocytosis, enlist more defensive elements |
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t cells |
defense against intracellular antigens indirect-CD4 (helper cells), help B cells find antigen, direct macrophages and response direct-CD8 (cytotoxic), destroy cancer or virally infected cell |
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organ transplants |
autografts- from one body site to another in same person isografts-between identical twins allografts- between individuals that are not twins xenografts- from another animal species |
