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8 Cards in this Set

  • Front
  • Back

Four categories of immune hypersensitivity reactions

Immediate (Type I)hypersensitivity

Type 1 hypersensitivity classically mediated by..

IgE antubodies directed against specific antigens

Mast cells activation in Type 1 hypersensitivity

C3a C5a


Chemokines


Drug (codeine morphine)


Melliton


Physical stimuli

Activation of mast cells and basophils in type 1 hypersensitivity

Mediators released in initial rapid response of type 1 hypersensitivity

Biogenic amines, enzymes, proteoglycans

Mediators of second phase of type 1 hypersensitivity

Lipid mediators


Leukotrienes B4/ C4,D4,E4


Prostaglandin D2


PAF

Type III hypersensitivity is mediated by ?

Antigen-antibody complex (immune complexes)

Three phases of systemic disease of type 3 hypersensitivity

1. Formation of immune complexes


2. Deposition of immune complexes


3. Injury caused by immune complexes