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12 Cards in this Set
- Front
- Back
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what is the nonspecific response to fungi?
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barriers
NEUTROPHILS-most imp phagocyte alveolar MPh-inhaled fungi (many fungi resist MPh killing w/ melanin prod) NK cells-infected cells |
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what is the nonspecific response important for?
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PREVENTION of infections
most ppl with sufficient immune response dont dev fungal disease |
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what is the specific response to fungal infections?
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TH1 inflamm for intracell infection
-O2 dependent CTLs, DTH activated MPh important once infection established, TH2 resp is counterprod; Ig MAY prevent colonization before infection |
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what can some fungi induce that result in tissue damage?
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HSR
immune response causes damage |
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sporothrix schenckii: gen charac
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"rose growers disease"
dimorphic fungi (extracellular) transmission via subQ trauma by environmental source |
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what is disease caused by sporothrix schenckii?
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skin lesions
progress to necrotic, ulcerative lesion draining lymphatics thickened "cordlike"; subQ nodules, abscesses may be self limiting or invasive dep on pts immune resp |
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prevention, resolution sporothrix schenckii
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innate-PMNs and inflammation
adaptive: prevention- no known immunity established w/repeat exposure resolution- TH1 w/ strong inflamm resp TH2-chronic disease DTH response-granulomatous lesions |
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coccidiodes immitis: gen charac
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"valley fever"
dimorphic disease due to extracellular yeast form mold in environment w/ reproductive spores can cause systemic disease by entering lymphatics |
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how is coccidiodes immitis transmitted?
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inhalation of spores (arthroconidia)
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disease caused by coccidiodes immitis?
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influenza-like
fever, cough; may progress to pneumonia in immunocompromised unresolved-disseminated nodular skin lesions, arthralgias |
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prevention, resolution coccidiodes immitis?
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innate- inflamm; effective in healthy indiv (alveolar MPh phagocytize fungi, rel cytokines to attract PMNs-inflamm)
adaptive: prevention- Ig against mold phase; some protection via repeated low level stim (MPh also present to TH0->TH1, memory T cells) resolution-TH1 w/ strong inflamm |
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problem with diagnosing ppl in endemic area presenting with fungal infection?
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if inject microbe (coccidiodes immitis) under skin would have positive wheal, flare b/c memory response
can't assume this is the microbe causing the present infection |
