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6 Cards in this Set

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  • Back
Complement factors deficient in Classical pathway AND S/S?
C1q, C1r, C1s, C4, C2 deficiency.
Marked increase in immune complex Dz, increased infection with pyogenic bacteria
Complement deficiency of the Alternative pathway AND what increased suseptibility to?
Factor B or properdin - inability to make C3bBb or stabilize it.

Increased suspetibilty to Neisseria infections
Complement factor deficiency affecting both pathways AND S/S?
C3
Recurrent bacterial infections, immune complex Dz
Complement factor deficiency affecting both pathways AND Increaed suspetibility?
C5-C8

Menigicoccal and gonococcal infections
Complement factor deficiency affecting regulatory proteins?
C1-INH leading to overuse of C1, C4, C2 causing hereditary angioedema
Dx by decreased C4 levels b/c of excess use of the early components
Complement factor deficiency affecting regulatory proteins causing paroxysmal nocturnal hemoglobinuria?
Decay-activating factor or homologous restriction factor