Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

7 Cards in this Set

  • Front
  • Back
Molecular Defect in Burton's hypogammaglobulinemia?
X-linked recessive defect in a Tyrosine Kinase gene (BtK gene)
Sx of Burton's Hypogammaglobulinemia?
Recurrent bacterial infections after 6 Mo; Low leveles of all calsses of IG;mB-cell cell maturation in bone marrow stops at pre-B stage, NML CMI
Tx of Burton's
Monthly gammaglobulin replacement and abx for infection
Sx of selective IgA deficiency?
Recurrent Sinopulmonary and GI infections
Tx for Selective IgA deficinecy (MC primary immunodeficinecy)
Abx, not immunoglubulins
Molecular defect causing Hyper-IgM syndrome?
Defect in CD40L (ligand)costimulatory molecule on CD4 T helper cells leading to inability to class switch since no stimulatory signal given to B cell.
Sx of Hyper-IgM syndrome?
High IgM titers, very low IgG, IgE, IgA
Children present with recurrent resp infections bacterial and PCP.
T-cell independent Ag (i.e.LPS) Not affected