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14 Cards in this Set

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What are the 2 B-Cell deficiencies?
Bruton's agammaglobulinemia

Selective immunoglobulin deficiency
What are the 2 T-Cell deficiencies?
Thymic aplasia (DiGeorge Syndrome)

Chronic mucocutaneous candidiasis
What are 3 B and T cell deficiencies?
Severe Combined Immunodeficiency

Wiskott-Aldrich Syndrome

Ataxia-telengiectasia
What are some phagocytic deficiencies?
(6)
Chronic granulomatous
Chediak-Higashi
Job's Syndrome
Leukocyte adhesion deficiency syndrome
Hyper-IgM syndrome
IL-12 receptor deficiency
X linked recessive defect in tyrosine kinase gene; low levels of all classes of immunoglobulins ?
Bruton's
deficiency in isotype switching; IgA deficincy is most obvious --"> sinus and lung infections?
selective immunglobulin deficiency
Tetany; failure of 3rd and 4th pharyngeal pouches to develop...

recurrent viral and fungal infections
DiGeorge's

thymus and parathyroids fail to develop
Triad of symptoms: pyogenic infections, eczema and thrombocytopenia

X-Linked
Wiskott-Aldrich Syndrome
Defect in early stem cell differentiation

mAY BE DUE TO ADENOSINE DEAMINASE DEFICIENCY, DEFECTIVE iL-2 RECEPTORS OR failure to synthesize MHC II antigens
severe combined immunodeficiency

recurrent viral, bacterial, fungal infections

no B or T cells
Defect in DNA reepair enzymes

IgA deficiency
Ataxia-telengiectasia
Lack of NADPH oxidase activity?
Chronic granulomatous disease
How would you test for chronic granulomatous disease?
negative nitroblue tetrazolium dye reduction test
Defect in microtubular function and lysosomal emptying of the phagocytic cells?
Chediak -Higashi
Failure of gamma-interferon production by helper T CELLS?
Job's syndrome